2019
Mitofusin 2 in Mature Adipocytes Controls Adiposity and Body Weight
Mancini G, Pirruccio K, Yang X, Blücher M, Rodeheffer M, Horvath TL. Mitofusin 2 in Mature Adipocytes Controls Adiposity and Body Weight. Cell Reports 2019, 26: 2849-2858.e4. PMID: 30865877, PMCID: PMC6876693, DOI: 10.1016/j.celrep.2019.02.039.Peer-Reviewed Original ResearchConceptsKnockout miceBody weightMitochondria-endoplasmic reticulum interactionSystemic metabolic dysregulationImpaired glucose metabolismHigh-fat dietObese human subjectsCalorie-dense foodsMitofusin 2Control miceStandard chowLean controlsMetabolic dysregulationFood intakeAdult miceGlucose metabolismStandard dietAdipose tissueBrown fatGlucose utilizationAdiposityTissue levelsSystemic levelsMiceAdult animals
2017
Microglial Proliferation in Obesity: When, Where, Why, and What Does It Mean?
Chowen JA, Horvath TL, Argente J. Microglial Proliferation in Obesity: When, Where, Why, and What Does It Mean? Diabetes 2017, 66: 804-805. PMID: 28325742, PMCID: PMC5360305, DOI: 10.2337/dbi16-0073.Peer-Reviewed Original Research
2016
Elevated O-GlcNAcylation promotes gastric cancer cells proliferation by modulating cell cycle related proteins and ERK 1/2 signaling
Jiang M, Qiu Z, Zhang S, Fan X, Cai X, Xu B, Li X, Zhou J, Zhang X, Chu Y, Wang W, Liang J, Horvath T, Yang X, Wu K, Nie Y, Fan D. Elevated O-GlcNAcylation promotes gastric cancer cells proliferation by modulating cell cycle related proteins and ERK 1/2 signaling. Oncotarget 2016, 7: 61390-61402. PMID: 27542217, PMCID: PMC5308659, DOI: 10.18632/oncotarget.11359.Peer-Reviewed Original ResearchMeSH KeywordsAcetylglucosamineAnimalsCell CycleCell Line, TumorCell ProliferationCyclin D1Cyclin-Dependent Kinase 2Down-RegulationFemaleGene Knockdown TechniquesHumansMaleMAP Kinase Signaling SystemMiceMice, Inbred BALB CMice, NudeMiddle AgedMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3N-AcetylglucosaminyltransferasesPhosphorylationProtein Processing, Post-TranslationalRNA InterferenceRNA, Small InterferingSerineStomach NeoplasmsThreonineUp-RegulationXenograft Model Antitumor AssaysConceptsO-GlcNAcylationERK 1/2GlcNAcylation levelsCell cycleInhibition of OGTCell proliferationVivo xenograft assaysGastric cancer cell proliferationGC cell proliferationERK 1/2 pathwayERK-1/2 signalingThreonine residuesGastric cancer cell linesGlcNAc transferaseO-GlcNAcCancer cell proliferationTarget proteinsOGT levelsGastric epithelial cellsOnly enzymeXenograft assayPotential novel therapeutic targetPhosphorylation levelsCDK-2Cancer cell lines
2012
Ucp2 Induced by Natural Birth Regulates Neuronal Differentiation of the Hippocampus and Related Adult Behavior
Simon-Areces J, Dietrich MO, Hermes G, Garcia-Segura LM, Arevalo MA, Horvath TL. Ucp2 Induced by Natural Birth Regulates Neuronal Differentiation of the Hippocampus and Related Adult Behavior. PLOS ONE 2012, 7: e42911. PMID: 22905184, PMCID: PMC3414493, DOI: 10.1371/journal.pone.0042911.Peer-Reviewed Original ResearchConceptsUCP2 expressionCellular stressHippocampal neuronsChemical inhibitionMitochondrial bioenergeticsNeuronal differentiationGenetic ablationNatural birthProtein 2Adult behaviorCell proliferationCritical roleAdult brainNeuronal numberExpressionBioenergeticsNeuronsBirthDifferentiationRegulationProliferationSynaptogenesisVitroNeuroprotectionHippocampus
2010
An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness
Procaccini C, De Rosa V, Galgani M, Abanni L, Calì G, Porcellini A, Carbone F, Fontana S, Horvath TL, La Cava A, Matarese G. An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness. Immunity 2010, 33: 929-941. PMID: 21145759, PMCID: PMC3133602, DOI: 10.1016/j.immuni.2010.11.024.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4 AntigensCell ProliferationCells, CulturedClonal AnergyDisease ProgressionEncephalomyelitis, Autoimmune, ExperimentalForkhead Transcription FactorsHumansInterleukin-2Interleukin-2 Receptor alpha SubunitLeptinMiceMice, Inbred C57BLSignal TransductionSirolimusT-Lymphocytes, RegulatoryTOR Serine-Threonine KinasesConceptsTreg cellsAnergic stateInterleukin-2Treg cell expansionRegulatory T cellsExogenous interleukin-2T cell responsivenessCell receptor stimulationImmune toleranceT cellsCell responsivenessReceptor stimulationMTOR activationEarly downregulationMammalian targetMTOR kinase activityRapamycin (mTOR) pathwayProliferative capabilityTransient inhibitionUnderlying mechanismElevated activityEnergy metabolismCellsResponsivenessCell expansionFgfr2 Is Required for the Development of the Medial Prefrontal Cortex and Its Connections with Limbic Circuits
Stevens HE, Smith KM, Maragnoli ME, Fagel D, Borok E, Shanabrough M, Horvath TL, Vaccarino FM. Fgfr2 Is Required for the Development of the Medial Prefrontal Cortex and Its Connections with Limbic Circuits. Journal Of Neuroscience 2010, 30: 5590-5602. PMID: 20410112, PMCID: PMC2868832, DOI: 10.1523/jneurosci.5837-09.2010.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexCerebral cortexFibroblast growth factor receptorCKO miceExcitatory neuronsPrefrontal cortexCortical neuron developmentEntire cerebral cortexRadial glial cellsSpecific fibroblast growth factor receptorsGrowth factor receptorGABAergic neuronsLimbic circuitsCortical neuronsGlial cellsSubcortical stationsBed nucleusCortical developmentLimbic systemStria terminalisSynaptic terminalsSecondary decreaseNeuronal precursorsVentricular zoneNeuron development