Maternal and Offspring Pools of Osteocalcin Influence Brain Development and Functions
Oury F, Khrimian L, Denny CA, Gardin A, Chamouni A, Goeden N, Huang YY, Lee H, Srinivas P, Gao XB, Suyama S, Langer T, Mann JJ, Horvath TL, Bonnin A, Karsenty G. Maternal and Offspring Pools of Osteocalcin Influence Brain Development and Functions. Cell 2013, 155: 228-241. PMID: 24074871, PMCID: PMC3864001, DOI: 10.1016/j.cell.2013.08.042.Peer-Reviewed Original ResearchConceptsOsteoblast-derived hormone osteocalcinBrain developmentBone-derived signalsBlood-brain barrierFetal brain developmentInfluences brain developmentBone massNeuronal apoptosisMonoamine neurotransmittersGABA synthesisMemory deficitsNeuroanatomical defectsOffspring poolPostnatal functionMaternal genotypeMetabolic functionsOsteocalcinPowerful regulationBrainMaternal influenceRegulationBrainstemPregnancyHippocampusMidbrain