Clozapine promotes glycolysis and myelin lipid synthesis in cultured oligodendrocytes
Steiner J, Martins-de-Souza D, Schiltz K, Sarnyai Z, Westphal S, Isermann B, Dobrowolny H, Turck CW, Bogerts B, Bernstein HG, Horvath TL, Schild L, Keilhoff G. Clozapine promotes glycolysis and myelin lipid synthesis in cultured oligodendrocytes. Frontiers In Cellular Neuroscience 2014, 8: 384. PMID: 25477781, PMCID: PMC4235405, DOI: 10.3389/fncel.2014.00384.Peer-Reviewed Original ResearchMyelin lipid synthesisMetabolic side effectsAdverse metabolic effectsEffects of clozapineHigh extracellular levelsOLN-93 oligodendrocytesRelease of lactateExpression of galactocerebrosideWhite matter integrityExpression of glucoseLipid synthesisOligodendrocyte dysfunctionFree fatty acidsLactate levelsMetabolic effectsGlucose metabolismSide effectsSchizophrenia therapyExtracellular levelsMyelin lipid metabolismClozapineLipid metabolismHaloperidolGlucose uptakeOligodendrocytes