2002
Host genetic profiles predict virological and immunological control of HIV-1 infection in adolescents
Tang J, Wilson CM, Meleth S, Myracle A, Lobashevsky E, Mulligan MJ, Douglas SD, Korber B, Vermund SH, Kaslow RA. Host genetic profiles predict virological and immunological control of HIV-1 infection in adolescents. AIDS 2002, 16: 2275-2284. PMID: 12441799, DOI: 10.1097/00002030-200211220-00007.Peer-Reviewed Original ResearchConceptsViral loadHLA class IHost genetic profileHIV-1-infected adolescentsHIV-1-seropositive participantsCD4 T-cell countClass IHIV-seronegative individualsT-cell countsCD4 T lymphocytesHIV-1 infectionHIV-1 pathogenesisGenetic profileClinical patient groupsAntiretroviral therapyQuarterly followMultivariable analysisHealth cohortPatient groupImmunological outcomesImmunological controlNegative HLAT lymphocytesProtective effectAdolescent care
1999
Rapid Communication CCR5 Genotype and Resistance to Vertical Transmission of HIV-1
Philpott S, Burger H, Charbonneau T, Grimson R, Vermund S, Visosky A, Nachman S, Kovacs A, Tropper P, Frey H, Weiser B. Rapid Communication CCR5 Genotype and Resistance to Vertical Transmission of HIV-1. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1999, 21: 189-193. PMID: 10421241, DOI: 10.1097/00126334-199907010-00002.Peer-Reviewed Original ResearchConceptsHIV-1 infectionHIV-1Vertical transmissionCCR5 genotypeHIV-1 infection statusHIV-1 vertical transmissionHIV-1-infected mothersPrimary HIV-1 infectionMacrophage-tropic strainsAfrican AmericansParenteral transmissionUninfected childrenChild transmissionInfected childrenInfected mothersInfected womenDelta32 mutationCCR5 receptorInfection statusWhite childrenCCR5MothersChildrenHomozygous genotypeAdditional strategies