1991
Effect of zidovudine and Pneumocystis carinii pneumonia prophylaxis on progression of HIV-1 infection to AIDS
STUDY T, Graham N, Zeger S, Park L, Saah A, Phair J, Detels R, Vermund S, Ho M. Effect of zidovudine and Pneumocystis carinii pneumonia prophylaxis on progression of HIV-1 infection to AIDS. The Lancet 1991, 338: 265-269. PMID: 1677108, DOI: 10.1016/0140-6736(91)90414-k.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAerosolsCD4-Positive T-LymphocytesEvaluation Studies as TopicFollow-Up StudiesHIV SeropositivityHIV-1HumansLeukocyte CountMalePentamidinePneumonia, PneumocystisProspective StudiesRegression AnalysisRisk FactorsTime FactorsTrimethoprim, Sulfamethoxazole Drug CombinationZidovudineConceptsPneumocystis carinii pneumoniaEffect of zidovudineHIV-1 infectionPCP prophylaxisProbability of progressionLymphocytes/First episodePneumocystis carinii pneumonia prophylaxisHIV-1-infected individualsHIV-1-seropositive menMonth intervalsPrimary PCP prophylaxisEfficacy of zidovudinePresence of HIVRate of progressionMultivariate log-linear modelPneumonia prophylaxisMore CD4Primary prophylaxisZidovudine therapyLymphocyte countCarinii pneumoniaClinical trialsObservational studyProphylaxis
1990
How can epidemiology assist in guiding interventions for the acquired immunodeficiency syndrome/human immunodeficiency virus?
Vermund S, Hoth D. How can epidemiology assist in guiding interventions for the acquired immunodeficiency syndrome/human immunodeficiency virus? Annals Of Epidemiology 1990, 1: 141-155. PMID: 1669495, DOI: 10.1016/1047-2797(90)90005-d.Peer-Reviewed Original ResearchConceptsNew therapiesHIV infectionTherapeutic trialsClinical trialsImmunodeficiency syndrome/human immunodeficiency virusVaccine developmentHuman immunodeficiency virus (HIV) infectionRecent drug trialsImmunodeficiency virus infectionDevelopment of AIDSHost immunologic responseHuman immunodeficiency virusSuch clinical parametersFuture epidemiologic researchClinical therapeutic researchNatural history studiesUse of condomsEffect of treatmentClinical research methodsVariety of treatmentsAIDS/HIV epidemicClinical courseClinical outcomesClinical parametersImmunodeficiency virus