2022
Does Voluntary Medical Male Circumcision Reduce HIV Risk in Men Who Have Sex with Men?
Lin Y, Gao Y, Sun Y, Turner D, Zou H, Vermund S, Qian H. Does Voluntary Medical Male Circumcision Reduce HIV Risk in Men Who Have Sex with Men? Current HIV/AIDS Reports 2022, 19: 522-525. PMID: 36520379, DOI: 10.1007/s11904-022-00637-7.Peer-Reviewed Original ResearchMeSH KeywordsCircumcision, MaleHIV InfectionsHumansMaleRisk Reduction BehaviorSexual and Gender MinoritiesSexual BehaviorConceptsVoluntary medical male circumcisionRandomized clinical trialsHIV riskMedical male circumcisionPurpose of ReviewToSubgroup of menHIV prevalenceClinical trialsAnal sexMale circumcisionPopulation-level impactAvailable evidenceMSMInsertive roleConflicting resultsMenSexRiskOriginal studyEfficacyInterventionEvidenceReviewToStrong evidencePrevalenceVoluntary Medical Male Circumcision to Reduce HIV Acquisition and Transmission
Vermund S. Voluntary Medical Male Circumcision to Reduce HIV Acquisition and Transmission. Current HIV/AIDS Reports 2022, 19: 471-473. PMID: 36478080, PMCID: PMC10767716, DOI: 10.1007/s11904-022-00631-z.Peer-Reviewed Original ResearchMeSH KeywordsAfrica South of the SaharaCircumcision, MaleFemaleHIV InfectionsHumansIncidenceMalePrevalenceConceptsHIV acquisitionVoluntary medical male circumcisionHIV infection acquisitionVoluntary medical male circumcision (VMMC) programsMinor surgical interventionsMale circumcision programsHIV incidence ratesHigh HIV prevalenceMedical male circumcisionFirst clinical trialUninfected menHIV incidenceHIV prevalenceInfection acquisitionSaharan AfricaSurgical interventionCircumcision programsClinical trialsIncidence ratePreventive benefitsHIV riskCircumcision ratesRecent FindingsSinceMale circumcisionHealth sectionVoluntary Medical Male Circumcision for HIV Prevention: a Global Overview
Zhang C, Vermund S. Voluntary Medical Male Circumcision for HIV Prevention: a Global Overview. Current HIV/AIDS Reports 2022, 19: 474-483. PMID: 36348186, DOI: 10.1007/s11904-022-00632-y.Peer-Reviewed Original ResearchConceptsVoluntary medical male circumcisionMedical male circumcisionHIV preventionMale circumcisionPrevention strategiesEvidence-based HIV prevention strategiesBehavioral prevention strategiesHigher sexual risk behaviorsHIV prevention strategiesSexual risk behaviorsPurpose of ReviewWithDecreased riskClinical trialsCircumcision coverageVMMC coverageProtective effectRecent FindingsThereHealth professionalsSystematic reviewIncidence areaRisk behaviorsSexual partnersHealth authoritiesHealth systemMale partners
2021
Association between medical male circumcision and HIV risk compensation among heterosexual men: a systematic review and meta-analysis
Gao Y, Yuan T, Zhan Y, Qian HZ, Sun Y, Zheng W, Fu L, Liang B, Zhu Z, Ouyang L, Liu M, Fitzpatrick T, Wu Z, Meng X, Baeten JM, Zhao J, Vermund SH, Yu M, Wu G, Su B, Zou H. Association between medical male circumcision and HIV risk compensation among heterosexual men: a systematic review and meta-analysis. The Lancet Global Health 2021, 9: e932-e941. PMID: 33939956, PMCID: PMC8690595, DOI: 10.1016/s2214-109x(21)00102-9.Peer-Reviewed Original ResearchConceptsMedical male circumcisionHigh-risk sexual behaviorOdds ratioMultiple sex partnersSex partnersHIV infectionMale circumcisionMantel-Haenszel random-effects modelSystematic reviewCondom useHeterosexual menLow self-perceived riskAdjusted odds ratioSelf-perceived riskPooled odds ratioHIV preventive measuresMultiple sexual partnersSexual behaviorRandom-effects modelSexual health educationOriginal study dataCircumcision prevalenceCochrane LibrarySubgroup analysisEligible studies
2019
Predicting the long-term impact of voluntary medical male circumcision on HIV incidence among men who have sex with men in Beijing, China
Zhang C, Webb GF, Lou J, Shepherd BE, Qian HZ, Liu Y, Vermund SH. Predicting the long-term impact of voluntary medical male circumcision on HIV incidence among men who have sex with men in Beijing, China. AIDS Care 2019, 32: 343-353. PMID: 31619058, PMCID: PMC6981072, DOI: 10.1080/09540121.2019.1679704.Peer-Reviewed Original ResearchMeSH KeywordsBeijingChinaCircumcision, MaleHIV InfectionsHomosexuality, MaleHumansIncidenceMaleModels, TheoreticalSexual and Gender MinoritiesConceptsVoluntary medical male circumcisionNew HIV casesMedical male circumcisionHIV incidenceHIV casesMale circumcisionSignificant public health impactHIV prevention interventionsPublic health impactCoverage ratePrevention interventionsNew infectionsEvidence baseMSMMenHealth impactsIncidenceCircumcisionLong-term impactFirst studyDifferent coverage ratesInfectionPrevalenceBaselineModeling economic and epidemiological impact of voluntary medical male circumcision among men who have sex with men in Beijing, China
Zhang C, Penson DF, Qian HZ, Webb GF, Lou J, Shephard BE, Liu Y, Vermund SH. Modeling economic and epidemiological impact of voluntary medical male circumcision among men who have sex with men in Beijing, China. International Journal Of STD & AIDS 2019, 30: 630-638. PMID: 30890118, PMCID: PMC6666307, DOI: 10.1177/0956462419831859.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBeijingCircumcision, MaleCosts and Cost AnalysisHIV InfectionsHomosexuality, MaleHumansIncidenceMaleVoluntary ProgramsConceptsVoluntary medical male circumcisionNew HIV casesMedical male circumcisionHIV casesMale circumcisionHIV/AIDS epidemicCoverage rateHIV acquisitionHIV incidenceCumulative numberCircumcision ratesDeterministic compartmental modelEpidemiological impactVMMC implementationAIDS epidemicMenMSMCircumcisionSexYearsCompartmental modelCasesIncidence
2016
Why wait? We need to scale-up infant male circumcision for global HIV control
Davey D, Vermund SH, Wamai R, Phili R, Klausner JD. Why wait? We need to scale-up infant male circumcision for global HIV control. AIDS 2016, 30: 1847-1848. PMID: 27088322, PMCID: PMC10767709, DOI: 10.1097/qad.0000000000001121.Peer-Reviewed Original ResearchLower HIV Risk Among Circumcised Men Who Have Sex With Men in China
Qian HZ, Ruan Y, Liu Y, Milam DF, Spiegel HM, Yin L, Li D, Shepherd BE, Shao Y, Vermund SH. Lower HIV Risk Among Circumcised Men Who Have Sex With Men in China. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2016, 71: 444-451. PMID: 26413852, PMCID: PMC4767598, DOI: 10.1097/qai.0000000000000856.Peer-Reviewed Original ResearchConceptsLower oddsHIV infectionGenital examinationMale circumcisionVoluntary medical male circumcisionLifetime male sexual partnersHIV heterosexual transmissionMale sexual transmissionLow HIV riskInsertive anal sexInsertive anal intercourseMedical male circumcisionMale sexual partnersAnal sex rolesUncircumcised menCircumcision statusHeterosexual transmissionSexual transmissionInsertive sexClinical trialsHIV riskCircumcision ratesSyphilis riskAnal intercourseLower risk
2014
HPTN 071 (PopART): Rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment – a study protocol for a cluster randomised trial
Hayes R, Ayles H, Beyers N, Sabapathy K, Floyd S, Shanaube K, Bock P, Griffith S, Moore A, Watson-Jones D, Fraser C, Vermund SH, Fidler S, The HPTN 071 (PopART) Study Team. HPTN 071 (PopART): Rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment – a study protocol for a cluster randomised trial. Trials 2014, 15: 57. PMID: 24524229, PMCID: PMC3929317, DOI: 10.1186/1745-6215-15-57.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnti-HIV AgentsCircumcision, MaleClinical ProtocolsCost-Benefit AnalysisDrug Administration ScheduleFemaleHealth Care CostsHIV InfectionsHumansIncidenceMaleMass ScreeningPredictive Value of TestsPrevalenceResearch DesignSouth AfricaTime FactorsTreatment OutcomeYoung AdultZambiaConceptsImmediate antiretroviral treatmentAntiretroviral treatmentHIV incidenceHIV testingCombination HIV prevention packageHIV combination prevention interventionsHome-based HIV testingUniversal testingCombination prevention interventionsHIV prevention packageHPTN 071 (PopART) trialUniversal HIV testingHIV-negative menCluster-randomised trialCurrent national guidelinesStandard of careMedical male circumcisionPublic health problemThree-arm designPotential adverse effectsART initiationHPTN 071Testing HIVSecondary outcomesArm B
2013
Can Combination Prevention Strategies Reduce HIV Transmission in Generalized Epidemic Settings in Africa? The HPTN 071 (PopART) Study Plan in South Africa and Zambia
Vermund SH, Fidler SJ, Ayles H, Beyers N, Hayes RJ. Can Combination Prevention Strategies Reduce HIV Transmission in Generalized Epidemic Settings in Africa? The HPTN 071 (PopART) Study Plan in South Africa and Zambia. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2013, 63: s221-s227. PMID: 23764639, PMCID: PMC3739051, DOI: 10.1097/qai.0b013e318299c3f4.Peer-Reviewed Original ResearchConceptsHIV Prevention Trials NetworkHPTN 071 (PopART) studyHPTN 071HIV incidenceHIV transmissionHome-based HIV testingVoluntary medical male circumcisionGeneralized epidemic settingsLinkage of HIVUniversal antiretroviral therapyChild HIV transmissionPrevention of motherHIV viral loadCommunity health workersMedical male circumcisionCommunity-randomized trialIntervention strategiesCombination prevention strategiesAntiretroviral therapyHIV acquisitionSeropositive personsTuberculosis servicesHIV testingViral loadTuberculosis transmissionTranslation of Biomedical Prevention Strategies for HIV
Vermund SH, Tique JA, Cassell HM, Pask ME, Ciampa PJ, Audet CM. Translation of Biomedical Prevention Strategies for HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2013, 63: s12-s25. PMID: 23673881, PMCID: PMC3725750, DOI: 10.1097/qai.0b013e31829202a2.Peer-Reviewed Original ResearchConceptsPrevention of motherPrevention strategiesClean injection equipmentChild HIV transmissionBiomedical approachBiomedical prevention strategiesRisk of acquisitionHIV prevention strategiesBehavioral risk reductionHigh-prevalence regionsRisk of transmissionCircumcision of menBlood product safetyChild transmissionHIV transmissionAntiretroviral drugsPrevalence regionsHIV preventionHIVFamily planningMore childrenPreventionRisk reductionInjection equipmentSaharan Africa
2010
Combination HIV Prevention: Significance, Challenges, and Opportunities
Kurth AE, Celum C, Baeten JM, Vermund SH, Wasserheit JN. Combination HIV Prevention: Significance, Challenges, and Opportunities. Current HIV/AIDS Reports 2010, 8: 62-72. PMID: 20941553, PMCID: PMC3036787, DOI: 10.1007/s11904-010-0063-3.Peer-Reviewed Original ResearchConceptsHIV prevention strategiesHIV transmissionPrevention strategiesPopulation-level HIV transmissionBehavioral risk reductionEvidence-based strategiesNumber of interventionsAntiretroviral medicationsHIV serostatusPrevention packageUninfected personsEpidemiologic profileHIV pandemicMale circumcisionNeedle exchangeEffective interventionsTarget populationInterventionRisk reductionMeasurable reductionPopulation levelDiverse subgroupsMedicationsSerostatusHIV
2009
Willingness to Be Circumcised for Preventing HIV among Chinese Men Who Have Sex with Men
Ruan Y, Qian HZ, Li D, Shi W, Li Q, Liang H, Yang Y, Luo F, Vermund SH, Shao Y. Willingness to Be Circumcised for Preventing HIV among Chinese Men Who Have Sex with Men. AIDS Patient Care And STDs 2009, 23: 315-321. PMID: 19335172, PMCID: PMC2743100, DOI: 10.1089/apc.2008.0199.Peer-Reviewed Original ResearchConceptsClinical trialsChinese MSMChinese menMale circumcisionEffectiveness of circumcisionLack of historyUncircumcised MSMHIV acquisitionHIV/Genital hygieneAdult circumcisionFree medical servicesTight foreskinSide effectsSexual partnersInfection riskMSMCircumcisionPreventing HIVMedical servicesTrialsMenHeterosexual menCommunity educationSex
2008
Circumcision and HIV Prevention Among Men Who Have Sex With Men: No Final Word
Vermund SH, Qian HZ. Circumcision and HIV Prevention Among Men Who Have Sex With Men: No Final Word. JAMA 2008, 300: 1698-1700. PMID: 18840846, DOI: 10.1001/jama.300.14.1698.Peer-Reviewed Original Research
2007
The Future of HIV Prevention: Control of Sexually Transmitted Infections and Circumcision Interventions
Sahasrabuddhe VV, Vermund SH. The Future of HIV Prevention: Control of Sexually Transmitted Infections and Circumcision Interventions. Infectious Disease Clinics Of North America 2007, 21: 241-257. PMID: 17502238, PMCID: PMC2700301, DOI: 10.1016/j.idc.2007.03.005.Peer-Reviewed Original ResearchConceptsHIV infectionGenital tract inflammationMale circumcision programsSTI treatmentCircumcision programsSymptomatic personsHIV preventionCurrent evidenceMale circumcisionCircumcision interventionsInfectionHIVSeparate trialsPreventionTreatmentResearch prioritiesInflammationPersonsControlTrialsCircumcision