2023
High-Level Drug-Resistant Mutations among HIV-1 Subtype A6 and CRF02_AG in Kazakhstan
Sanaubarova A, Pujol-Hodge E, Dzissyuk N, Lemey P, Vermund S, Brown A, Ali S. High-Level Drug-Resistant Mutations among HIV-1 Subtype A6 and CRF02_AG in Kazakhstan. Viruses 2023, 15: 1407. PMID: 37515095, PMCID: PMC10384832, DOI: 10.3390/v15071407.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsDrug Resistance, ViralGenotypeHIV InfectionsHIV-1HumansKazakhstanMutationPhylogenyConceptsAntiretroviral therapySubtype A6Drug-resistant mutationsDrug resistanceEffective antiretroviral therapySuppressive antiretroviral therapyAntiretroviral drug resistanceDrug resistance monitoringHigh-level drug resistanceDrug regimensHIV incidenceHIV epidemicHIV-1Sustained transmissionMolecular epidemiologySubtypesPLHIVHIVG190SDifferent mutational pathwaysMutationsK101ED67NHigh levelsA62V
2022
Antiretroviral therapy resistance mutations among HIV infected people in Kazakhstan
Mukhatayeva A, Mustafa A, Dzissyuk N, Issanov A, Mukhatayev Z, Bayserkin B, Vermund SH, Ali S. Antiretroviral therapy resistance mutations among HIV infected people in Kazakhstan. Scientific Reports 2022, 12: 17195. PMID: 36229577, PMCID: PMC9562405, DOI: 10.1038/s41598-022-22163-7.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsDarunavirDrug Resistance, ViralEmtricitabineHIV InfectionsHIV-1HumansKazakhstanMutationNevirapineViral LoadZidovudine
2013
Impact of HIV drug resistance on virologic and immunologic failure and mortality in a cohort of patients on antiretroviral therapy in China
Liao L, Xing H, Su B, Wang Z, Ruan Y, Wang X, Liu Z, Lu Y, Yang S, Zhao Q, Vermund SH, Chen RY, Shao Y. Impact of HIV drug resistance on virologic and immunologic failure and mortality in a cohort of patients on antiretroviral therapy in China. AIDS 2013, 27: 1815-1824. PMID: 23803794, PMCID: PMC3694318, DOI: 10.1097/qad.0b013e3283611931.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyHIV drug resistanceImmunologic failureHigh mortalityVirologic failureAntiretroviral therapyEmergence of HIVDRBaseline CD4 cell countDrug resistanceCD4 cell countCohort of patientsSecond-line drugsEnd of studyProportional hazards modelRural Chinese countiesHIVDR mutationsMedian timePatient adherenceKaplan-MeierChinese patientsRisk factorsHazards modelPatientsCell countMortality
2012
The HIV Epidemic: High-Income Countries
Vermund SH, Leigh-Brown AJ. The HIV Epidemic: High-Income Countries. Cold Spring Harbor Perspectives In Medicine 2012, 2: a007195. PMID: 22553497, PMCID: PMC3331688, DOI: 10.1101/cshperspect.a007195.Peer-Reviewed Original ResearchConceptsInjection drug useHIV epidemicDrug useNeedle/syringe sharingReceptive anal intercourseDifferent risk groupsRecent explosive epidemicsAntiretroviral therapyChild transmissionSyringe sharingAffected subgroupRisk groupsAnal intercourseVaginal intercourseHIV vulnerabilityExplosive epidemicsDiagnostic screeningEpidemicIncome countriesIntercourseUnited StatesSpecific strainsHigh-income nationsHIVTherapy
2011
Antiretroviral Drug Resistance Mutations Among Treated and Treatment-Naive Patients in Pakistan: Diversity of the HIV Type 1 pol Gene in Pakistan
Shah S, Xing H, Altaf A, Chen B, Liao L, Jia Y, Vermund SH, Shao Y. Antiretroviral Drug Resistance Mutations Among Treated and Treatment-Naive Patients in Pakistan: Diversity of the HIV Type 1 pol Gene in Pakistan. AIDS Research And Human Retroviruses 2011, 27: 1277-1282. PMID: 21591988, PMCID: PMC3227241, DOI: 10.1089/aid.2010.0324.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnti-HIV AgentsCross-Sectional StudiesDrug Resistance, ViralFemaleGenes, polGenetic VariationHIV-1HumansMaleMiddle AgedMutationPakistanConceptsInjection drug usersAntiretroviral drugsDrug resistanceAntiretroviral drug resistance mutationsCalibrated Population Resistance toolHIV-1 subtype A1HIV-1-infected participantsPartial reverse transcriptase regionsARV drug resistanceARV-naive patientsPopulation Resistance toolSpouses of HIVTreatment-naive patientsPrimary drug resistanceHIV-1 subtypesDrug resistance mutationsFemale sex workersReverse transcriptase regionBlood spot cardsNaive patientsHIV patientsDrug adherenceSubtype DARV resistancePredominant subtype