2022
Antiretroviral therapy resistance mutations among HIV infected people in Kazakhstan
Mukhatayeva A, Mustafa A, Dzissyuk N, Issanov A, Mukhatayev Z, Bayserkin B, Vermund SH, Ali S. Antiretroviral therapy resistance mutations among HIV infected people in Kazakhstan. Scientific Reports 2022, 12: 17195. PMID: 36229577, PMCID: PMC9562405, DOI: 10.1038/s41598-022-22163-7.Peer-Reviewed Original Research
2016
Integrated prevention of mother-to-child HIV transmission services, antiretroviral therapy initiation, and maternal and infant retention in care in rural north-central Nigeria: a cluster-randomised controlled trial
Aliyu MH, Blevins M, Audet CM, Kalish M, Gebi UI, Onwujekwe O, Lindegren ML, Shepherd BE, Wester CW, Vermund SH. Integrated prevention of mother-to-child HIV transmission services, antiretroviral therapy initiation, and maternal and infant retention in care in rural north-central Nigeria: a cluster-randomised controlled trial. The Lancet HIV 2016, 3: e202-e211. PMID: 27126487, PMCID: PMC4852280, DOI: 10.1016/s2352-3018(16)00018-7.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdolescentAdultAnti-HIV AgentsCD4 Lymphocyte CountDelivery of Health Care, IntegratedEarly Intervention, EducationalFamilyFemaleHIV InfectionsHumansInfantInfectious Disease Transmission, VerticalMaleMothersNevirapineNigeriaPregnancyPregnancy Complications, InfectiousPrenatal CareRural PopulationYoung AdultConceptsChild HIV transmissionAntiretroviral therapyStandard of careRural North-Central NigeriaWeeks post partumIntervention groupAntiretroviral prophylaxisEligible womenHIV statusHIV transmissionSecondary level health care facilitiesChild HIV transmission servicesClinical stage 1 diseasePost partumEunice Kennedy Shriver National InstituteMedian CD4 countPMTCT service deliveryAntiretroviral therapy initiationCD4 cell countPrevention of motherStage 1 diseaseUnknown HIV statusElimination of motherNorth Central NigeriaEarly infant diagnosis
2011
Improving Retention in the Early Infant Diagnosis of HIV Program in Rural Mozambique by Better Service Integration
Ciampa PJ, Burlison JR, Blevins M, Sidat M, Moon TD, Rothman RL, Vermund SH. Improving Retention in the Early Infant Diagnosis of HIV Program in Rural Mozambique by Better Service Integration. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2011, 58: 115-119. PMID: 21546845, DOI: 10.1097/qai.0b013e31822149bf.Peer-Reviewed Original ResearchConceptsEarly infant diagnosisInfant diagnosisInfant testingEarly infant testingWomen/infantsRetrospective record reviewPostpartum HIVRural MozambiqueRecord reviewStandard referralHIV programsHigher oddsReferral processSimple interventionHIVReferralDiagnosisInfant retentionWomenService integrationInfants
2010
A cluster-randomized trial of enhanced labor ward-based PMTCT services to increase nevirapine coverage in Lusaka, Zambia
Megazzini KM, Sinkala M, Vermund SH, Redden DT, Krebs DW, Acosta EP, Mwanza J, Goldenberg RL, Chintu N, Bulterys M, Stringer JS. A cluster-randomized trial of enhanced labor ward-based PMTCT services to increase nevirapine coverage in Lusaka, Zambia. AIDS 2010, 24: 447-455. PMID: 19926959, DOI: 10.1097/qad.0b013e328334b285.Peer-Reviewed Original ResearchConceptsWomen/infant pairsCluster-randomized trialNevirapine coverageInfant pairsLabour wardClinic coverageProbability of HIVProportion of HIVPrevention of motherStandard of carePMTCT programmePMTCT servicesChild transmissionHIV testingUnknown serostatusSurveillance periodIntervention periodControl clinicsRelative riskTreatment clinicsUmbilical cordHIVClinicGEE modelOdds of coverage
2009
Predictors of Rapid HIV Testing Acceptance and Successful Nevirapine Administration in Zambian Labor Wards
Megazzini KM, Chintu N, Vermund SH, Redden DT, Krebs DW, Simwenda M, Tambatamba B, Sinkala M, Stringer JS. Predictors of Rapid HIV Testing Acceptance and Successful Nevirapine Administration in Zambian Labor Wards. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2009, 52: 273-279. PMID: 19568175, DOI: 10.1097/qai.0b013e3181ab6e7c.Peer-Reviewed Original ResearchConceptsNevirapine administrationHIV testingHIV statusHIV testing acceptanceChild transmission servicesTime of admissionProvision of HIVResource-limited settingsSusceptible womenEligible womenPrimigravida womenHIV counselingCervical dilationLabour wardTesting acceptanceEligibility criteriaTesting ratesInert tabletsWomenHIVAdministrationCounselingPredictorsHoursStatusSelected hematologic and biochemical measurements in African HIV-infected and uninfected pregnant women and their infants: the HIV Prevention Trials Network 024 protocol
Mwinga K, Vermund SH, Chen YQ, Mwatha A, Read JS, Urassa W, Carpenetti N, Valentine M, Goldenberg RL. Selected hematologic and biochemical measurements in African HIV-infected and uninfected pregnant women and their infants: the HIV Prevention Trials Network 024 protocol. BMC Pediatrics 2009, 9: 49. PMID: 19664210, PMCID: PMC2746190, DOI: 10.1186/1471-2431-9-49.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsBlood Cell CountDouble-Blind MethodFemaleFollow-Up StudiesGestational AgeHematocritHemoglobinsHIVHIV InfectionsHumansIncidenceInfantInfant, NewbornMalawiNevirapinePregnancyPregnancy Complications, InfectiousRetrospective StudiesRNA, ViralTanzaniaTreatment OutcomeYoung AdultZambiaConceptsHIV infectionPregnant African womenRandomized clinical trialsTime of laborComplete laboratory dataWeeks of ageNevirapine prophylaxisChild transmissionHIV exposureWeeks' gestationHIV statusPregnant womenNewborn infantsClinical trialsPublic clinicsHIVInfantsBiochemical measurementsCaucasian populationWomenLaboratory dataNormative dataAfrican womenInfectionWeeks
2007
Early clinical and immune response to NNRTI-based antiretroviral therapy among women with prior exposure to single-dose nevirapine
Chi BH, Sinkala M, Stringer EM, Cantrell RA, Mtonga V, Bulterys M, Zulu I, Kankasa C, Wilfert C, Weidle PJ, Vermund SH, Stringer J. Early clinical and immune response to NNRTI-based antiretroviral therapy among women with prior exposure to single-dose nevirapine. AIDS 2007, 21: 957-964. PMID: 17457089, PMCID: PMC2745970, DOI: 10.1097/qad.0b013e32810996b2.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountDrug Administration ScheduleEpidemiologic MethodsFemaleHIV InfectionsHumansInfectious Disease Transmission, VerticalNevirapinePregnancyPregnancy Complications, InfectiousReverse Transcriptase InhibitorsTreatment FailureTreatment OutcomeConceptsSingle-dose nevirapineClinical treatment failureCD4 cell responseAntiretroviral therapyTreatment failureNVP exposureTreatment outcomesCell responsesShort-term treatment outcomesPrior exposureChild HIV transmissionPrevention of motherCD4 cell changesPoor treatment outcomesNon-nucleoside reverseSignificant differencesWorld Health Organization guidelinesHealth Organization guidelinesART initiationCohort evaluationMultivariable analysisHIV transmissionHIV treatmentRisk factorsImmune response
2005
Effectiveness of a city-wide program to prevent mother-to-child HIV transmission in Lusaka, Zambia
Stringer JS, Sinkala M, Maclean CC, Levy J, Kankasa C, DeGroot A, Stringer EM, Acosta EP, Goldenberg RL, Vermund SH. Effectiveness of a city-wide program to prevent mother-to-child HIV transmission in Lusaka, Zambia. AIDS 2005, 19: 1309-1315. PMID: 16052086, PMCID: PMC2745046, DOI: 10.1097/01.aids.0000180102.88511.7d.Peer-Reviewed Original ResearchConceptsMother-infant pairsHIV testingCord bloodSurveillance populationAntenatal HIV testingPerinatal HIV preventionProportion of HIVChild HIV transmissionHIV test resultsMain outcome measuresNewborn cord bloodHIV prevention programsHIV serologyInfant dosePublic sector facilitiesSeropositive womenAntenatal careHIV transmissionPrescribed regimenCascade of eventsLabor onsetPopulation effectivenessSurveillance periodHIV preventionOutcome measures
2004
Universal nevirapine upon presentation in labor to prevent mother-to-child HIV transmission in high prevalence settings
Stringer J, Sinkala M, Goldenberg RL, Kumwenda R, Acosta EP, Aldrovandi GM, Stout JP, Vermund SH. Universal nevirapine upon presentation in labor to prevent mother-to-child HIV transmission in high prevalence settings. AIDS 2004, 18: 939-943. PMID: 15060442, PMCID: PMC2745979, DOI: 10.1097/00002030-200404090-00012.Peer-Reviewed Original ResearchConceptsChild HIV transmissionUnknown HIV serostatusHIV serostatusHIV transmissionPreliminary efficacyLabour wardHIV DNA polymerase chain reactionSingle-dose nevirapinePrevention of motherProspective cohort studyEvidence of infectionHigh-prevalence settingsWeeks of lifeNevirapine administrationNevirapine coverageChild transmissionCohort studyComparison cohortAdherence ratesPrevalence settingsPolymerase chain reactionCord bloodDNA polymerase chain reactionHIVInfant specimens
2003
Nevirapine to prevent mother-to-child transmission of HIV-1 among women of unknown serostatus
Stringer J, Rouse DJ, Sinkala M, Marseille EA, Vermund SH, Stringer EM, Goldenberg RL. Nevirapine to prevent mother-to-child transmission of HIV-1 among women of unknown serostatus. The Lancet 2003, 362: 1850-1853. PMID: 14654326, DOI: 10.1016/s0140-6736(03)14907-0.Peer-Reviewed Original ResearchMonitoring nevirapine-based programmes for prevention of mother-to-child transmission of HIV-1
Stringer J, Sinkala M, Goldenberg R, Vermund S, Acosta E. Monitoring nevirapine-based programmes for prevention of mother-to-child transmission of HIV-1. The Lancet 2003, 362: 667. PMID: 12944077, DOI: 10.1016/s0140-6736(03)14172-4.Peer-Reviewed Original ResearchTiming of the maternal drug dose and risk of perinatal HIV transmission in the setting of intrapartum and neonatal single-dose nevirapine
Stringer J, Sinkala M, Chapman V, Acosta EP, Aldrovandi GM, Mudenda V, Stout JP, Goldenberg RL, Kumwenda R, Vermund SH. Timing of the maternal drug dose and risk of perinatal HIV transmission in the setting of intrapartum and neonatal single-dose nevirapine. AIDS 2003, 17: 1659-1665. PMID: 12853748, PMCID: PMC2745973, DOI: 10.1097/00002030-200307250-00010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBreast FeedingDrug Administration ScheduleFemaleHIV InfectionsHIV SeropositivityHumansInfant, NewbornInfectious Disease Transmission, VerticalLabor, ObstetricNevirapineObstetric Labor ComplicationsPregnancyPregnancy Complications, InfectiousProspective StudiesReverse Transcriptase InhibitorsRisk FactorsTime FactorsConceptsPerinatal HIV transmissionHIV transmissionInfant HIV infection statusNeonatal single-dose nevirapineMaternal drug doseSingle-dose nevirapineHIV infection statusProspective cohort studyPerinatal transmission rateOnset of laborMain outcome measuresMean drug concentrationWeeks of lifeRisk of transmissionNVP levelsNVP prophylaxisNVP syrupObstetrical clinicPerinatal transmissionCohort studyOral doseViral loadPregnant womenPolymerase chain reactionRisk factorsPrevention of mother-to-child transmission of HIV in Africa: successes and challenges in scaling-up a nevirapine-based program in Lusaka, Zambia
Stringer EM, Sinkala M, Stringer J, Mzyece E, Makuka I, Goldenberg RL, Kwape P, Chilufya M, Vermund SH. Prevention of mother-to-child transmission of HIV in Africa: successes and challenges in scaling-up a nevirapine-based program in Lusaka, Zambia. AIDS 2003, 17: 1377-1382. PMID: 12799559, PMCID: PMC2745990, DOI: 10.1097/00002030-200306130-00012.Peer-Reviewed Original ResearchConceptsPrevention of motherResource-limited settingsHIV infectionVoluntary counselingChild HIV transmissionPerinatal HIV infectionHIV prevention programsNVP therapyChild transmissionPatient attritionHIV transmissionPregnant womenPrevention programsNevirapineHIVHealth employeesThousands of womenTransmission routesLusakaMothersInfectionPreventionWomenCounselingInfantsComparison of Two Strategies for Administering Nevirapine to Prevent Perinatal HIV Transmission in High-Prevalence, Resource-Poor Settings
Stringer JS, Sinkala M, Stout JP, Goldenberg RL, Acosta EP, Chapman V, Kumwenda-Phiri R, Vermund SH. Comparison of Two Strategies for Administering Nevirapine to Prevent Perinatal HIV Transmission in High-Prevalence, Resource-Poor Settings. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2003, 32: 506-513. PMID: 12679702, PMCID: PMC2745994, DOI: 10.1097/00126334-200304150-00007.Peer-Reviewed Original ResearchConceptsHigh-prevalence settingsClinic AClinic BVCT servicesPrevent Perinatal HIV TransmissionPerinatal HIV acquisitionPerinatal HIV preventionPerinatal HIV transmissionKnowledge of serostatusResource-poor settingsNevirapine therapyNVP therapyHIV acquisitionHIV testingHIV statusHIV transmissionPregnant womenCord bloodHIV preventionHigh prevalenceInfant deathUniversal therapyClinicTherapyMaternal reports
2002
Effect of nevirapine toxicity on choice of perinatal HIV prevention strategies.
Stringer JS, Sinkala M, Rouse DJ, Goldenberg RL, Vermund SH. Effect of nevirapine toxicity on choice of perinatal HIV prevention strategies. American Journal Of Public Health 2002, 92: 365-6. PMID: 11867311, PMCID: PMC1447080, DOI: 10.2105/ajph.92.3.365.Peer-Reviewed Original Research
2001
Zambian women's attitudes toward mass nevirapine therapy to prevent perinatal transmission of HIV
Sinkala M, Stout J, Vermund S, Goldenberg R, Stringer J. Zambian women's attitudes toward mass nevirapine therapy to prevent perinatal transmission of HIV. The Lancet 2001, 358: 1611-1612. PMID: 11716891, DOI: 10.1016/s0140-6736(01)06662-4.Peer-Reviewed Original Research
2000
Cost-Effective Use of Nevirapine to Prevent Vertical HIV Transmission in Sub-Saharan Africa
Stringer J, Rouse D, Vermund S, Goldenberg R, Sinkala M, Stinnett A. Cost-Effective Use of Nevirapine to Prevent Vertical HIV Transmission in Sub-Saharan Africa. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 24: 369-377. DOI: 10.1097/00042560-200008010-00012.Peer-Reviewed Original ResearchConceptsVertical HIV transmissionHIV transmissionPrenatal carePrevention strategiesEffects of NVPModest clinical efficacyOptimal prevention strategiesGreater health gainsDecision analysis modelNevirapine administrationNVP administrationPrenatal visitPreventive therapyStandard therapyClinical efficacySaharan AfricaMass therapyPrenatal strategiesClinical assessmentPrior enrollmentTherapyCost-effective useHealth gainsWomenSerostatusCost-effective use of nevirapine to prevent vertical HIV transmission in sub-Saharan Africa.
Stringer J, Rouse D, Vermund S, Goldenberg R, Sinkala M, Stinnett A. Cost-effective use of nevirapine to prevent vertical HIV transmission in sub-Saharan Africa. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 24: 369-77. PMID: 11015154, DOI: 10.1097/00126334-200008010-00012.Peer-Reviewed Original ResearchConceptsVertical HIV transmissionHIV transmissionPrenatal carePrevention strategiesEffects of NVPModest clinical efficacyOptimal prevention strategiesSaharan AfricaGreater health gainsDecision analysis modelNevirapine administrationNVP administrationPrenatal visitPreventive therapyStandard therapyClinical efficacyMass therapyPrenatal strategiesClinical assessmentPrior enrollmentTherapyCost-effective useHealth gainsWomenSerostatus