2023
Combination HIV prevention during pregnancy and the post‐partum period in Malawi and Zambia: a mathematical modelling analysis
Powers K, Mutale W, Rosenberg N, Graybill L, Mollan K, Freeborn K, Saidi F, Maman S, Mulenga P, Jahn A, Nyirenda R, Stringer J, Vermund S, H. B. Combination HIV prevention during pregnancy and the post‐partum period in Malawi and Zambia: a mathematical modelling analysis. Journal Of The International AIDS Society 2023, 26: e26128. PMID: 37403422, PMCID: PMC10320044, DOI: 10.1002/jia2.26128.Peer-Reviewed Original ResearchConceptsFemale HIV transmissionMaternal HIV acquisitionMaternal HIV incidenceHIV prevention strategiesPost-partum periodAntiretroviral therapyHIV transmissionMale partnersHIV acquisitionHIV incidenceANC patientsPrevention strategiesCombination HIV prevention strategiesCombination HIV prevention interventionSuppressive antiretroviral therapyPre-exposure prophylaxisVertical HIV transmissionAntenatal care programsCombination HIV preventionHIV prevention interventionsANC initiationART initiationUnsuppressed HIVIncident infectionsUndiagnosed HIVHigh-Level Drug-Resistant Mutations among HIV-1 Subtype A6 and CRF02_AG in Kazakhstan
Sanaubarova A, Pujol-Hodge E, Dzissyuk N, Lemey P, Vermund S, Brown A, Ali S. High-Level Drug-Resistant Mutations among HIV-1 Subtype A6 and CRF02_AG in Kazakhstan. Viruses 2023, 15: 1407. PMID: 37515095, PMCID: PMC10384832, DOI: 10.3390/v15071407.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsDrug Resistance, ViralGenotypeHIV InfectionsHIV-1HumansKazakhstanMutationPhylogenyConceptsAntiretroviral therapySubtype A6Drug-resistant mutationsDrug resistanceEffective antiretroviral therapySuppressive antiretroviral therapyAntiretroviral drug resistanceDrug resistance monitoringHigh-level drug resistanceDrug regimensHIV incidenceHIV epidemicHIV-1Sustained transmissionMolecular epidemiologySubtypesPLHIVHIVG190SDifferent mutational pathwaysMutationsK101ED67NHigh levelsA62V
2022
Antiretroviral therapy resistance mutations among HIV infected people in Kazakhstan
Mukhatayeva A, Mustafa A, Dzissyuk N, Issanov A, Mukhatayev Z, Bayserkin B, Vermund SH, Ali S. Antiretroviral therapy resistance mutations among HIV infected people in Kazakhstan. Scientific Reports 2022, 12: 17195. PMID: 36229577, PMCID: PMC9562405, DOI: 10.1038/s41598-022-22163-7.Peer-Reviewed Original Research
2021
Poor retention and care-related sex disparities among youth living with HIV in rural Mozambique
Ahonkhai AA, Aliyu MH, Audet CM, Bravo M, Simmons M, Claquin G, Memiah P, Fernando AN, Carlucci JG, Shepherd BE, Van Rompaey S, Yu Z, Gong W, Vermund SH, Wester CW. Poor retention and care-related sex disparities among youth living with HIV in rural Mozambique. PLOS ONE 2021, 16: e0250921. PMID: 34019582, PMCID: PMC8139489, DOI: 10.1371/journal.pone.0250921.Peer-Reviewed Original ResearchConceptsHigher oddsCombination antiretroviral therapy (cART) initiationCox proportional hazards modelCare continuum outcomesComprehensive HIV programsPost-ART initiationYoung adults 15Antiretroviral therapy initiationRetrospective cohort studySex-related disparitiesMultivariable logistic regressionOne-year followProportional hazards modelYears of agePL femalesSex-related differencesART initiationAYA cohortTherapy initiationCohort studyContinuum outcomesHIV outcomesClinical visitsAdults 15HIV programs
2019
Attrition of HIV-positive children from HIV services in low and middle-income countries.
Carlucci JG, Liu Y, Clouse K, Vermund SH. Attrition of HIV-positive children from HIV services in low and middle-income countries. AIDS 2019, 33: 2375-2386. PMID: 31764102, PMCID: PMC6905128, DOI: 10.1097/qad.0000000000002366.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsChildDeveloping CountriesHIV InfectionsHumansLost to Follow-UpRetention in CareVulnerable PopulationsConceptsHIV-positive childrenHIV servicesAntiretroviral therapyMiddle-income countriesEarly ART initiationPatient support servicesOptimal health outcomesMeta-regression analysisART initiationLTFU definitionStudy eligibilityMagnitude of attritionEligibility criteriaHealth outcomesSystematic reviewRandom-effects meta-analytic methodsOverall attritionMeta-analytic methodsMultidatabase searchData extractionVulnerable populationsImplementation researchMonthsMost attritionLTFUTreatment as Prevention: Concepts and Challenges for Reducing HIV Incidence
Brault MA, Spiegelman D, Hargreaves J, Nash D, Vermund SH. Treatment as Prevention: Concepts and Challenges for Reducing HIV Incidence. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2019, 82: s104-s112. PMID: 31658196, PMCID: PMC6820703, DOI: 10.1097/qai.0000000000002168.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyHIV transmissionHIV plasma loadReducing HIV IncidenceHIV prevention trialsCommunity-level interventionsDeployable vaccineViral suppressionHIV testingHIV incidencePrevention trialsUninfected personsChronic conditionsHIV investmentsEarly treatmentTreat strategySexual partnersViral expressionTransmission riskHIVTrialsTreatmentInconsistent findingsPreventionSaharan AfricaIncreasing male engagement in the prevention of vertical transmission of HIV: what works in sub-Saharan Africa?
Aliyu MH, Sam-Agudu NA, Shenoi S, Goga AE, Ramraj T, Vermund SH, Audet CM. Increasing male engagement in the prevention of vertical transmission of HIV: what works in sub-Saharan Africa? The BMJ 2019, 365: l1965. PMID: 31171558, PMCID: PMC6598674, DOI: 10.1136/bmj.l1965.Peer-Reviewed Original Research
2018
Negative associations between general self-efficacy and anxiety/depression among newly HIV-diagnosed men who have sex with men in Beijing, China
Wang N, Wang S, Qian HZ, Ruan Y, Amico KR, Vermund SH, Yin L, Qiu X, Zheng S. Negative associations between general self-efficacy and anxiety/depression among newly HIV-diagnosed men who have sex with men in Beijing, China. AIDS Care 2018, 31: 629-635. PMID: 30466302, PMCID: PMC7942229, DOI: 10.1080/09540121.2018.1549721.Peer-Reviewed Original ResearchConceptsDepression/anxietyChinese MSMLogistic regressionAnxiety/depressionBaseline survey dataNegative associationPotential confoundersClinical trialsStudy populationChinese menHIVOverall healthBaseline surveyMSMCumulative logistic regressionDepressionMenAnxietyAssociationTrialsSexLow levelsHigh levelsConfoundersRegressionExploration of Implementation Patterns and Content from a Text-Based Outreach Intervention Clinical Trial for Newly Diagnosed, HIV-Positive MSM in Beijing, China
Knudson A, Shaw S, Yin L, Xiao D, Qian HZ, Sullivan S, Liu H, Ruan Y, Shao Y, Vermund SH, Amico KR. Exploration of Implementation Patterns and Content from a Text-Based Outreach Intervention Clinical Trial for Newly Diagnosed, HIV-Positive MSM in Beijing, China. AIDS And Behavior 2018, 23: 1158-1165. PMID: 30288683, PMCID: PMC6566097, DOI: 10.1007/s10461-018-2287-y.Peer-Reviewed Original Research
2017
Control of HIV epidemic: improve access to testing and ART
Vermund SH. Control of HIV epidemic: improve access to testing and ART. The Lancet HIV 2017, 4: e533-e534. PMID: 28867268, PMCID: PMC10950070, DOI: 10.1016/s2352-3018(17)30166-2.Peer-Reviewed Original ResearchMobility and Clinic Switching Among Postpartum Women Considered Lost to HIV Care in South Africa
Clouse K, Vermund SH, Maskew M, Lurie MN, MacLeod W, Malete G, Carmona S, Sherman G, Fox MP. Mobility and Clinic Switching Among Postpartum Women Considered Lost to HIV Care in South Africa. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2017, 74: 383-389. PMID: 28225717, PMCID: PMC5324708, DOI: 10.1097/qai.0000000000001284.Peer-Reviewed Original ResearchConceptsHIV careNational Health Laboratory Service databaseLow CD4 cell countsNational Antiretroviral Therapy ProgramCD4 cell countObservational cohort studyAntiretroviral therapy programsAntiretroviral therapyCohort studyPostpartum womenPublic clinicsService databaseCell countTherapy programCareWomenLTFUClinicOne-thirdDaysPatientsPregnancyTherapyMortality in Children with Human Immunodeficiency Virus Initiating Treatment: A Six-Cohort Study in Latin America
Luque MT, Jenkins CA, Shepherd BE, Padgett D, Rouzier V, Succi RCM, Machado DM, McGowan CC, Vermund SH, Pinto JA. Mortality in Children with Human Immunodeficiency Virus Initiating Treatment: A Six-Cohort Study in Latin America. The Journal Of Pediatrics 2017, 182: 245-252.e1. PMID: 28081884, PMCID: PMC5328796, DOI: 10.1016/j.jpeds.2016.12.034.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveCause of DeathChildChild, PreschoolCohort StudiesConfidence IntervalsDatabases, FactualDose-Response Relationship, DrugDrug Administration ScheduleFemaleHIV InfectionsHumansIncidenceLatin AmericaMaleProportional Hazards ModelsRetrospective StudiesRisk AssessmentSeverity of Illness IndexSurvival AnalysisConceptsCombination antiretroviral therapyYears of ageCART initiationGreater riskCox proportional hazards modelAntiretroviral therapy-naïveMedian CD4 countRetrospective cohort studyProportional hazards modelCumulative mortality incidenceSouth America networkProbability of deathInitiating treatmentMedian CD4Antiretroviral therapyCause mortalityCD4 countTherapy-naïveCohort studyCumulative incidenceHIV epidemiologyPediatric careMortality incidenceHazards modelRegimens
2016
Patient and Provider Satisfaction With a Comprehensive Strategy to Improve Prevention of Mother-to-Child HIV Transmission Services in Rural Nigeria
Boehmer A, Audet CM, Blevins M, Gebi UI, Wester CW, Vermund SH, Aliyu MH. Patient and Provider Satisfaction With a Comprehensive Strategy to Improve Prevention of Mother-to-Child HIV Transmission Services in Rural Nigeria. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2016, 72: s117-s123. PMID: 27355498, PMCID: PMC5113240, DOI: 10.1097/qai.0000000000001058.Peer-Reviewed Original ResearchConceptsPrevention of motherProvider satisfactionPatient satisfactionWeeks postpartumControl armIntervention sitesChild HIV transmission servicesChild HIV transmission rateMother-infant careCD4 cell countHIV transmission ratesCluster-randomized trialTotal patient satisfactionAntiretroviral therapyHIV careChild transmissionPrescribed treatmentClinician satisfactionHealth personnelLower cadre workersCell countHealth problemsMale involvementProvider rolesProviders' abilityIntegrated prevention of mother-to-child HIV transmission services, antiretroviral therapy initiation, and maternal and infant retention in care in rural north-central Nigeria: a cluster-randomised controlled trial
Aliyu MH, Blevins M, Audet CM, Kalish M, Gebi UI, Onwujekwe O, Lindegren ML, Shepherd BE, Wester CW, Vermund SH. Integrated prevention of mother-to-child HIV transmission services, antiretroviral therapy initiation, and maternal and infant retention in care in rural north-central Nigeria: a cluster-randomised controlled trial. The Lancet HIV 2016, 3: e202-e211. PMID: 27126487, PMCID: PMC4852280, DOI: 10.1016/s2352-3018(16)00018-7.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdolescentAdultAnti-HIV AgentsCD4 Lymphocyte CountDelivery of Health Care, IntegratedEarly Intervention, EducationalFamilyFemaleHIV InfectionsHumansInfantInfectious Disease Transmission, VerticalMaleMothersNevirapineNigeriaPregnancyPregnancy Complications, InfectiousPrenatal CareRural PopulationYoung AdultConceptsChild HIV transmissionAntiretroviral therapyStandard of careRural North-Central NigeriaWeeks post partumIntervention groupAntiretroviral prophylaxisEligible womenHIV statusHIV transmissionSecondary level health care facilitiesChild HIV transmission servicesClinical stage 1 diseasePost partumEunice Kennedy Shriver National InstituteMedian CD4 countPMTCT service deliveryAntiretroviral therapy initiationCD4 cell countPrevention of motherStage 1 diseaseUnknown HIV statusElimination of motherNorth Central NigeriaEarly infant diagnosis
2015
Practical Management of HIV-Associated Anemia in Resource-Limited Settings: Prospective Observational Evaluation of a New Mozambican Guideline
Brentlinger PE, Silva WP, Vermund SH, Valverde E, Buene M, Moon TD. Practical Management of HIV-Associated Anemia in Resource-Limited Settings: Prospective Observational Evaluation of a New Mozambican Guideline. AIDS Research And Human Retroviruses 2015, 32: 12-25. PMID: 26178574, PMCID: PMC4692124, DOI: 10.1089/aid.2015.0030.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnemiaAnthelminticsAnti-HIV AgentsAntimalarialsAntitubercular AgentsCD4 Lymphocyte CountCoinfectionDeveloping CountriesDisease ManagementFemaleHelminthiasisHemoglobinsHIV InfectionsHumansLost to Follow-UpMalaria, FalciparumMaleMozambiquePractice Guidelines as TopicProspective StudiesRural PopulationTuberculosis, PulmonaryConceptsHIV-associated anemiaAdverse drug reactionsDrug reactionsHemoglobin responseGuideline revisionsIron deficiencyLower body mass indexCo-trimoxazole prophylaxisDiscontinuation of zidovudineLaboratory-confirmed malariaProspective observational evaluationRural Zambézia ProvinceT-cell countsT-lymphocyte countsSmear-positive tuberculosisBody mass indexResource limited settingsResource-limited settingsLogistic regression modelsAnaemic HIVStudy cliniciansAntiretroviral therapyEsophageal candidiasisPresumptive treatmentAnemia managementUse of Pharmacokinetic Data in Novel Analyses to Determine the Effect of Topical Microbicides as Preexposure Prophylaxis Against HIV Infection
Vermund SH, Walker AS. Use of Pharmacokinetic Data in Novel Analyses to Determine the Effect of Topical Microbicides as Preexposure Prophylaxis Against HIV Infection. The Journal Of Infectious Diseases 2015, 213: 329-331. PMID: 26123566, PMCID: PMC4704664, DOI: 10.1093/infdis/jiv336.Peer-Reviewed Original ResearchEnrolment trends in a comprehensive HIV programme in rural north-central Nigeria: improved care indices, but declining quality of clinical data over time
Aliyu MH, Blevins M, Arinze F, Megazzini KM, Bussell S, Dunlap J, Odoh C, Gebi UI, Muhammad MY, Shepherd BE, Audet CM, Vermund SH, Wester CW. Enrolment trends in a comprehensive HIV programme in rural north-central Nigeria: improved care indices, but declining quality of clinical data over time. Pathogens And Global Health 2015, 109: 75-83. PMID: 25822098, PMCID: PMC4571821, DOI: 10.1179/2047773215y.0000000007.Peer-Reviewed Original ResearchConceptsComprehensive HIV programsHIV programsComprehensive HIV/AIDS servicesCell countAdvanced clinical diseaseClinical stage INorth Central NigeriaHIV/AIDS servicesRural North-Central NigeriaQuality improvement effortsMedian CD4Clinical stagingMedian ageHIV servicesCare indexClinical dataClinical diseaseStage IAIDS servicesPatientsWindow periodHemoglobin dataClinical servicesEnrollment yearCells/
2014
Management of Fever in Ambulatory HIV-Infected Adults in Resource-Limited Settings
Brentlinger PE, Silva WP, Buene M, Morais L, Valverde E, Vermund SH, Moon TD. Management of Fever in Ambulatory HIV-Infected Adults in Resource-Limited Settings. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2014, 67: 304-309. PMID: 25314251, PMCID: PMC5844466, DOI: 10.1097/qai.0000000000000304.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS-Related Opportunistic InfectionsAmbulatory CareAnti-Bacterial AgentsAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveBacterial InfectionsCD4 Lymphocyte CountDisease ManagementFemaleFeverHIV InfectionsHumansMaleMultivariate AnalysisOutcome Assessment, Health CarePractice Guidelines as TopicProspective StudiesRisk FactorsViral LoadConceptsManagement of feverLow CD4 T-lymphocyte countCD4 T-lymphocyte countLower body mass indexBacterial blood stream infectionsSpecific alternative diagnosesT-lymphocyte countsHistory of feverProspective observational studyBlood stream infectionsBody mass indexResource limited settingsAmbulatory HIVAntiretroviral therapyMalaria testingLower hemoglobinMass indexAdverse outcomesAlternative diagnosesObservational studyAxillary temperatureGuideline performanceMultivariate analysisHIVFeverPoor Clinical Outcomes for HIV Infected Children on Antiretroviral Therapy in Rural Mozambique: Need for Program Quality Improvement and Community Engagement
Vermund SH, Blevins M, Moon TD, José E, Moiane L, Tique JA, Sidat M, Ciampa PJ, Shepherd BE, Vaz LM. Poor Clinical Outcomes for HIV Infected Children on Antiretroviral Therapy in Rural Mozambique: Need for Program Quality Improvement and Community Engagement. PLOS ONE 2014, 9: e110116. PMID: 25330113, PMCID: PMC4203761, DOI: 10.1371/journal.pone.0110116.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyAntiretroviral therapyInfant diagnosisClinical outcomesEarly infant diagnosisPoor clinical outcomeYears of ageResource-limited settingsUnknown clinical outcomesCohort mortality ratesQuality improvement effortsART initiationCART initiationRural MozambiqueHIV servicesAdults 15HIV prevalenceKaplan-MeierHigher hemoglobinMedication pickupClinical dataOutcome treatmentNational guidelinesCase findingZambézia ProvinceAntiretroviral Therapy Program Expansion in Zambézia Province, Mozambique: Geospatial Mapping of Community-Based and Health Facility Data for Integrated Health Planning
Moon TD, Ossemane EB, Green AF, Ndatimana E, José E, Buehler CP, Wester CW, Vermund SH, Olupona O. Antiretroviral Therapy Program Expansion in Zambézia Province, Mozambique: Geospatial Mapping of Community-Based and Health Facility Data for Integrated Health Planning. PLOS ONE 2014, 9: e109653. PMID: 25329169, PMCID: PMC4201452, DOI: 10.1371/journal.pone.0109653.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsCommunity Health PlanningCommunity Health ServicesHIV InfectionsHumansMass ScreeningMozambiqueVoluntary ProgramsConceptsHIV populationZambézia ProvinceCommunity-based VCTCommunity-based voluntary counselingHIV testing resultsProgram demographic informationHIV seropositivity rateHealth facility dataProgram expansionHIV careVoluntary counselingSeropositivity rateTesting deliveryEvidence-based decisionsHealth planningTreatment monitoringGeospatial mappingDemographic informationHealth estimatesClinicFacility dataCommunity-BasedProgram planningCareVCT