2023
Age-dependent impairment in antibody responses elicited by a homologous CoronaVac booster dose
Filardi B, Monteiro V, Schwartzmann P, do Prado Martins V, Zucca L, Baiocchi G, Malik A, Silva J, Hahn A, Chen N, Pham K, Pérez-Then E, Miric M, Brache V, Cochon L, Larocca R, Della Rosa Mendez R, Silveira D, Pinto A, Croda J, Yildirim I, Omer S, Ko A, Vermund S, Grubaugh N, Iwasaki A, Lucas C, Initiative Y, Vogels C, Breban M, Koch T, Chaguza C, Tikhonova I, Castaldi C, Mane S, De Kumar B, Ferguson D, Kerantzas N, Peaper D, Landry M, Schulz W. Age-dependent impairment in antibody responses elicited by a homologous CoronaVac booster dose. Science Translational Medicine 2023, 15: eade6023. PMID: 36791210, DOI: 10.1126/scitranslmed.ade6023.Peer-Reviewed Original ResearchConceptsBooster doseAntibody responseNeutralization titersVirus-specific IgG titersOlder adultsAntiviral humoral immunityPlasma antibody responsesHigh-risk populationSARS-CoV-2 spikeYears of ageAge-dependent impairmentHeterologous regimensBooster dosesBooster vaccineCoronaVac vaccineIgG titersProtective immunityHumoral immunityHumoral responseCoronaVacOmicron waveBooster strategyAge groupsEarly controlVaccine
2021
Poor retention and care-related sex disparities among youth living with HIV in rural Mozambique
Ahonkhai AA, Aliyu MH, Audet CM, Bravo M, Simmons M, Claquin G, Memiah P, Fernando AN, Carlucci JG, Shepherd BE, Van Rompaey S, Yu Z, Gong W, Vermund SH, Wester CW. Poor retention and care-related sex disparities among youth living with HIV in rural Mozambique. PLOS ONE 2021, 16: e0250921. PMID: 34019582, PMCID: PMC8139489, DOI: 10.1371/journal.pone.0250921.Peer-Reviewed Original ResearchConceptsHigher oddsCombination antiretroviral therapy (cART) initiationCox proportional hazards modelCare continuum outcomesComprehensive HIV programsPost-ART initiationYoung adults 15Antiretroviral therapy initiationRetrospective cohort studySex-related disparitiesMultivariable logistic regressionOne-year followProportional hazards modelYears of agePL femalesSex-related differencesART initiationAYA cohortTherapy initiationCohort studyContinuum outcomesHIV outcomesClinical visitsAdults 15HIV programs
2020
Coinfection With HIV and SARS-CoV-2 in Wuhan, China: A 12-Person Case Series
Hu Y, Ma J, Huang H, Vermund SH. Coinfection With HIV and SARS-CoV-2 in Wuhan, China: A 12-Person Case Series. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2020, 85: 10.1097/qai.0000000000002424. PMID: 32568771, PMCID: PMC7446977, DOI: 10.1097/qai.0000000000002424.Peer-Reviewed Original ResearchConceptsAntiretroviral therapySARS-CoV-2Clinical improvementCase seriesLong-term antiretroviral therapyMild COVID-19 symptomsCOVID-19 coinfectionAcute COVID-19COVID-19 symptomsYears of ageCOVID-19Health care servicesPossible COVID-19 casesCoinfected PersonsAntiretroviral medicationsMedian ageIntensive careCOVID-19 casesClinical prognosisFavorable outcomeSevere symptomsAdditional casesCare servicesHIVInformed consent
2018
HIV-1 Transmission Clustering and Phylodynamics Highlight the Important Role of Young Men Who Have Sex with Men
Dennis AM, Volz E, Frost A, Hossain M, Poon AFY, Rebeiro P, Vermund SH, Sterling TR, Kalish ML. HIV-1 Transmission Clustering and Phylodynamics Highlight the Important Role of Young Men Who Have Sex with Men. AIDS Research And Human Retroviruses 2018, 34: 879-888. PMID: 30027754, PMCID: PMC6204570, DOI: 10.1089/aid.2018.0039.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsCluster AnalysisCross-Sectional StudiesFemaleGenotypeHIV InfectionsHIV-1Homosexuality, MaleHumansMaleMiddle AgedMolecular EpidemiologyPhylogenyPol Gene Products, Human Immunodeficiency VirusRetrospective StudiesRisk FactorsRNA, ViralSequence Analysis, DNATennesseeYoung AdultConceptsYoung MSMTransmission clustersHIV-1 pol sequencesTransmission riskComprehensive Care ClinicHIV transmission patternsVanderbilt Comprehensive Care ClinicYears of ageHIV molecular epidemiologyCross-sectional analysisHigh transmission riskClinical factorsCare clinicsRisk ratioClinical dataImportance of interventionsMSM riskPol sequencesTransmission clusteringYounger ageRisk behaviorsLogistic regressionMolecular epidemiologyMSMYoung menSevere outcomes associated with respiratory viruses in newborns and infants: a prospective viral surveillance study in Jordan
Khuri-Bulos N, Lawrence L, Piya B, Wang L, Fonnesbeck C, Faouri S, Shehabi A, Vermund SH, Williams JV, Halasa NB. Severe outcomes associated with respiratory viruses in newborns and infants: a prospective viral surveillance study in Jordan. BMJ Open 2018, 8: e021898. PMID: 29780032, PMCID: PMC5961648, DOI: 10.1136/bmjopen-2018-021898.Peer-Reviewed Original ResearchMeSH KeywordsAdenoviridaeAntiviral AgentsFemaleHumansInfantIntensive Care UnitsJordanLength of StayMaleOxygen Inhalation TherapyPalivizumabParainfluenza Virus 1, HumanProspective StudiesRespiratory Syncytial Virus InfectionsRespiratory Syncytial Virus VaccinesRespiratory Syncytial Virus, HumanRespiratory Tract InfectionsRhinovirusRisk FactorsConceptsLonger LOSLength of stayAcute respiratory infectionsIntensive care unitRespiratory syncytial virusOxygen therapyMechanical ventilationHospitalisation ratesICU admissionIllness severityRespiratory virusesMedical conditionsExtended breast feedingRSV vaccine developmentProspective cohort studyUnderlying medical conditionsChemotherapy-associated neutropeniaHuman parainfluenza virusesYears of ageCohort studyRespiratory symptomsBreast feedingRespiratory infectionsCare unitSyncytial virus
2017
Mortality in Children with Human Immunodeficiency Virus Initiating Treatment: A Six-Cohort Study in Latin America
Luque MT, Jenkins CA, Shepherd BE, Padgett D, Rouzier V, Succi RCM, Machado DM, McGowan CC, Vermund SH, Pinto JA. Mortality in Children with Human Immunodeficiency Virus Initiating Treatment: A Six-Cohort Study in Latin America. The Journal Of Pediatrics 2017, 182: 245-252.e1. PMID: 28081884, PMCID: PMC5328796, DOI: 10.1016/j.jpeds.2016.12.034.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveCause of DeathChildChild, PreschoolCohort StudiesConfidence IntervalsDatabases, FactualDose-Response Relationship, DrugDrug Administration ScheduleFemaleHIV InfectionsHumansIncidenceLatin AmericaMaleProportional Hazards ModelsRetrospective StudiesRisk AssessmentSeverity of Illness IndexSurvival AnalysisConceptsCombination antiretroviral therapyYears of ageCART initiationGreater riskCox proportional hazards modelAntiretroviral therapy-naïveMedian CD4 countRetrospective cohort studyProportional hazards modelCumulative mortality incidenceSouth America networkProbability of deathInitiating treatmentMedian CD4Antiretroviral therapyCause mortalityCD4 countTherapy-naïveCohort studyCumulative incidenceHIV epidemiologyPediatric careMortality incidenceHazards modelRegimens
2014
Poor Clinical Outcomes for HIV Infected Children on Antiretroviral Therapy in Rural Mozambique: Need for Program Quality Improvement and Community Engagement
Vermund SH, Blevins M, Moon TD, José E, Moiane L, Tique JA, Sidat M, Ciampa PJ, Shepherd BE, Vaz LM. Poor Clinical Outcomes for HIV Infected Children on Antiretroviral Therapy in Rural Mozambique: Need for Program Quality Improvement and Community Engagement. PLOS ONE 2014, 9: e110116. PMID: 25330113, PMCID: PMC4203761, DOI: 10.1371/journal.pone.0110116.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyAntiretroviral therapyInfant diagnosisClinical outcomesEarly infant diagnosisPoor clinical outcomeYears of ageResource-limited settingsUnknown clinical outcomesCohort mortality ratesQuality improvement effortsART initiationCART initiationRural MozambiqueHIV servicesAdults 15HIV prevalenceKaplan-MeierHigher hemoglobinMedication pickupClinical dataOutcome treatmentNational guidelinesCase findingZambézia ProvinceHIV and syphilis prevalence trends among men who have sex with men in Guangxi, China: yearly cross-sectional surveys, 2008–2012
Wang X, Lan G, Shen Z, Vermund SH, Zhu Q, Chen Y, Khoshnood K, Wu Z, Tang Z. HIV and syphilis prevalence trends among men who have sex with men in Guangxi, China: yearly cross-sectional surveys, 2008–2012. BMC Infectious Diseases 2014, 14: 367. PMID: 24993252, PMCID: PMC4091643, DOI: 10.1186/1471-2334-14-367.Peer-Reviewed Original ResearchConceptsYears of ageSyphilis prevalenceCross-sectional surveyCurrent syphilisHIV prevalencePrevalence trendsSexual intercourseIncident HIV casesAnnual cross-sectional surveyRisk factor dataSignificant predictorsRisk of HIVNational sentinel surveillanceYearly cross-sectional surveysHIV/AIDSSyphilis infectionHIV infectionHIV casesSentinel surveillanceRisk factorsBlood samplesHIVKey populationsMSMPrevalence
2011
Rotavirus Diarrhea Among Children Less Than 5 Years of Age in Urban Ghana
Binka E, Vermund SH, Armah GE. Rotavirus Diarrhea Among Children Less Than 5 Years of Age in Urban Ghana. The Pediatric Infectious Disease Journal 2011, 30: 716-718. PMID: 21646938, PMCID: PMC3149899, DOI: 10.1097/inf.0b013e318223bd85.Peer-Reviewed Original ResearchPrevalence, Incidence, and Recurrence of Oral Lesions Among HIV-Infected Patients on HAART in Alabama
Tamí-Maury IM, Willig JH, Jolly PE, Vermund S, Aban I, Hill JD, Wilson CM, Kempf MC. Prevalence, Incidence, and Recurrence of Oral Lesions Among HIV-Infected Patients on HAART in Alabama. Southern Medical Journal 2011, 104: 561-566. PMID: 21886064, DOI: 10.1097/smj.0b013e318224a15f.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAIDS-Related Opportunistic InfectionsAlabamaAntiretroviral Therapy, Highly ActiveCandidiasis, OralFemaleHIV InfectionsHumansIncidenceLeukoplakia, HairyLongitudinal StudiesMaleMiddle AgedMouth DiseasesOffice VisitsOral UlcerPrevalenceRecurrenceRetrospective StudiesStomatitis, HerpeticYoung AdultConceptsOral lesionsOropharyngeal candidiasisPeriod prevalenceOral conditionsActive antiretroviral therapyAvailability of HAARTLaboratory dataYears of agePatient's laboratory dataAntiretroviral therapyChart reviewHIV infectionRetrospective studyFrequent manifestationIncidence rateMedical careHAARTNew casesPatientsRecurrencePrevalenceIncident rateUniversity of AlabamaHIVLesions
1996
Declining Prevalence of Cervicovaginal Human Papillomavirus Infection With Age Is Independent of Other Risk Factors
BURK R, KELLY P, FELDMAN J, BROMBERG J, VERMUND S, DEHOVITZ J, LANDESMAN S. Declining Prevalence of Cervicovaginal Human Papillomavirus Infection With Age Is Independent of Other Risk Factors. Sexually Transmitted Diseases 1996, 23: 333-341. PMID: 8836027, DOI: 10.1097/00007435-199607000-00013.Peer-Reviewed Original ResearchConceptsPrevalence of HPVHuman papillomavirus infectionHPV infectionPapillomavirus infectionRisk factorsCervicovaginal human papillomavirus infectionGenital HPV infectionCervical HPV infectionWomen 45 yearsFemale genital tractLogistic regression analysisYears of ageSexual behaviorInner-city womenAge-dependent declineHPV immunityHPV prevalenceCervical diseaseCervicovaginal cellsGenital tractLow prevalenceOlder womenSex partnersYounger ageBiologic effects
1993
Rising HIV-Related Mortality in Young Americans
Vermund S. Rising HIV-Related Mortality in Young Americans. JAMA 1993, 269: 3034-3035. PMID: 8501847, DOI: 10.1001/jama.1993.03500230116039.Peer-Reviewed Original Research
1989
High Prevalence Rate of Human Papillomavirus Infection and Association With Abnormal Papanicolaou Smears in Sexually Active Adolescents
Rosenfeld WD, Vermund SH, Wentz SJ, Burk RD. High Prevalence Rate of Human Papillomavirus Infection and Association With Abnormal Papanicolaou Smears in Sexually Active Adolescents. JAMA Pediatrics 1989, 143: 1443-1447. PMID: 2556023, DOI: 10.1001/archpedi.1989.02150240065018.Peer-Reviewed Original ResearchConceptsAbnormal Papanicolaou smearsHuman papillomavirusHPV infectionHPV DNACytologic abnormalitiesPapanicolaou smearsPrevalence ratesLow-grade cervical intraepithelial neoplasiaRoutine cervical cytologic screeningMultiple lifetime sexual partnersHuman papillomavirus infectionCervical intraepithelial neoplasiaHPV types 6/11Cervical epithelial abnormalitiesCervical cytologic screeningHigh prevalence ratesYears of ageLifetime sexual partnersCervicovaginal lavageHPV presentUninfected patientsPapillomavirus infectionCervical neoplasiaCytologic screeningIntraepithelial neoplasia
1988
Detection of human papillomavirus deoxyribonucleic acid in exfoliated cervicovaginal cells as a predictor of cervical neoplasia in a high-risk population
Ritter D, Kadish A, Vermund S, Romney S, Villari D, Burk R. Detection of human papillomavirus deoxyribonucleic acid in exfoliated cervicovaginal cells as a predictor of cervical neoplasia in a high-risk population. American Journal Of Obstetrics And Gynecology 1988, 159: 1517-1525. PMID: 2849881, DOI: 10.1016/0002-9378(88)90587-x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBiopsyCarcinoma, Squamous CellCervix UteriDNA, ViralFemaleForecastingHumansMiddle AgedPapanicolaou TestPapillomaviridaeRisk FactorsSensitivity and SpecificityTherapeutic IrrigationTumor Virus InfectionsUterine Cervical DiseasesUterine Cervical NeoplasmsVaginaVaginal SmearsConceptsHuman papillomavirus detectionHuman papillomavirus deoxyribonucleic acidHuman papillomavirus typesHuman papillomavirus type 16Cervical lesionsHuman papillomavirusPapillomavirus detectionPapillomavirus type 16Cervicovaginal lavageCytologic examinationPapillomavirus typesType 16Older womenHuman papillomavirus-negative womenPositive findingsCancerous lesionsAbnormal cytologic findingsHospital colposcopy clinicHuman papillomavirus infectionHigh-risk populationNegative cytologic resultsYears of ageHuman papillomavirus type 18Colposcopy clinicPapillomavirus infection
1986
Health education and community participation in mass drug administration for malaria in Nicaragua
Garfield R, Vermund S. Health education and community participation in mass drug administration for malaria in Nicaragua. Social Science & Medicine 1986, 22: 869-877. PMID: 3529425, DOI: 10.1016/0277-9536(86)90241-8.Peer-Reviewed Original ResearchConceptsDrug AdministrationPrimary health care systemMalaria control activitiesMass drug administrationYears of ageHealth education activitiesMalaria control effortsAnti-malaria medicinesHealth care systemMalaria situationCase findingHealth educationCare systemAdministrationTarget populationControl activitiesRapid declineLocal community organizationsPopulationMalariaChloroquinePrimaquineIncidenceWeeksEducation activities