2023
Combination HIV prevention during pregnancy and the post‐partum period in Malawi and Zambia: a mathematical modelling analysis
Powers K, Mutale W, Rosenberg N, Graybill L, Mollan K, Freeborn K, Saidi F, Maman S, Mulenga P, Jahn A, Nyirenda R, Stringer J, Vermund S, H. B. Combination HIV prevention during pregnancy and the post‐partum period in Malawi and Zambia: a mathematical modelling analysis. Journal Of The International AIDS Society 2023, 26: e26128. PMID: 37403422, PMCID: PMC10320044, DOI: 10.1002/jia2.26128.Peer-Reviewed Original ResearchConceptsFemale HIV transmissionMaternal HIV acquisitionMaternal HIV incidenceHIV prevention strategiesPost-partum periodAntiretroviral therapyHIV transmissionMale partnersHIV acquisitionHIV incidenceANC patientsPrevention strategiesCombination HIV prevention strategiesCombination HIV prevention interventionSuppressive antiretroviral therapyPre-exposure prophylaxisVertical HIV transmissionAntenatal care programsCombination HIV preventionHIV prevention interventionsANC initiationART initiationUnsuppressed HIVIncident infectionsUndiagnosed HIV
2022
Factors that Affect the Frequency of HIV Testing in College Men Who Have Sex with Men — Northeast China, 2017–2018
Li M, Wu H, Shu W, Li Z, Yan H, Hui H, Li H, Yang Z, Vermund SH, Hu Y. Factors that Affect the Frequency of HIV Testing in College Men Who Have Sex with Men — Northeast China, 2017–2018. China CDC Weekly 2022, 4: 549-553. PMID: 35813888, PMCID: PMC9260086, DOI: 10.46234/ccdcw2022.118.Peer-Reviewed Original ResearchHuman immunodeficiency virus (HIV) testingHIV testing frequencyHIV testing servicesPrevalence of HIVRecreational drug usePublic health practiceHIV testingHIV transmissionYoung MSMVirus testingDrug useHealth practicesStudy periodMSMOnline interventionWhole study periodMenTesting servicesMore social contactsSexTesting frequencySocial contactHIVPrevalenceHIV-Positive Men Are More Likely to Be Hyper Linked Within College Student Social Network — Northeast China, 2017–2018
Li M, Wu H, Yan H, Zunong J, Hui H, Li H, Yang Z, Vermund S, Hu Y. HIV-Positive Men Are More Likely to Be Hyper Linked Within College Student Social Network — Northeast China, 2017–2018. China CDC Weekly 2022, 4: 951-955. PMID: 36483793, PMCID: PMC9713575, DOI: 10.46234/ccdcw2022.195.Peer-Reviewed Original ResearchPositive prevalenceNew human immunodeficiency virus (HIV) infectionsHuman immunodeficiency virus (HIV) infectionHIV incident infectionsHIV-seronegative MSMImmunodeficiency virus infectionHIV-positive MSMHIV-positive menPublic health practiceIncident infectionsRisky sexual behaviorHIV transmissionHIV preventionYoung MSMVirus infectionDisproportionate burdenHealth practicesMSMSocial contactOnline interventionSexual behaviorInfectionMenPrevalenceIncidence
2020
Trends of HIV, hepatitis C virus and syphilis seroprevalence among injection and non-injection drug users in southwestern China, 2010–2017
Jiang H, Zhang X, Zhang C, Lu R, Zhou C, Ouyang L, Xing H, Vermund SH, Shao Y, Ruan Y, Wu G, Qian HZ. Trends of HIV, hepatitis C virus and syphilis seroprevalence among injection and non-injection drug users in southwestern China, 2010–2017. AIDS Care 2020, 36: 612-617. PMID: 33345591, PMCID: PMC10767711, DOI: 10.1080/09540121.2020.1856320.Peer-Reviewed Original ResearchNon-injection drug usersHepatitis C virusDrug use behaviorsDrug usersHCV prevalenceC virusRisky drug use behaviorsTrends of HIVCross-sectional surveySyphilis seroprevalenceHIV prevalenceHIV transmissionPrevalence trendsPWIDDrug useHIVDisease preventionSexual contactUse behaviorsChi-squarePrevalenceSyphilisDrugsVirusPrimary risk
2019
Treatment as Prevention: Concepts and Challenges for Reducing HIV Incidence
Brault MA, Spiegelman D, Hargreaves J, Nash D, Vermund SH. Treatment as Prevention: Concepts and Challenges for Reducing HIV Incidence. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2019, 82: s104-s112. PMID: 31658196, PMCID: PMC6820703, DOI: 10.1097/qai.0000000000002168.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyHIV transmissionHIV plasma loadReducing HIV IncidenceHIV prevention trialsCommunity-level interventionsDeployable vaccineViral suppressionHIV testingHIV incidencePrevention trialsUninfected personsChronic conditionsHIV investmentsEarly treatmentTreat strategySexual partnersViral expressionTransmission riskHIVTrialsTreatmentInconsistent findingsPreventionSaharan AfricaIncreasing male engagement in the prevention of vertical transmission of HIV: what works in sub-Saharan Africa?
Aliyu MH, Sam-Agudu NA, Shenoi S, Goga AE, Ramraj T, Vermund SH, Audet CM. Increasing male engagement in the prevention of vertical transmission of HIV: what works in sub-Saharan Africa? The BMJ 2019, 365: l1965. PMID: 31171558, PMCID: PMC6598674, DOI: 10.1136/bmj.l1965.Peer-Reviewed Original Research
2018
Peer counselling versus standard‐of‐care on reducing high‐risk behaviours among newly diagnosed HIV‐positive men who have sex with men in Beijing, China: a randomized intervention study
Liu Y, Vermund SH, Ruan Y, Liu H, Amico K, Simoni JM, Shepherd BE, Shao Y, Qian H. Peer counselling versus standard‐of‐care on reducing high‐risk behaviours among newly diagnosed HIV‐positive men who have sex with men in Beijing, China: a randomized intervention study. Journal Of The International AIDS Society 2018, 21: e25079. PMID: 29430845, PMCID: PMC5808102, DOI: 10.1002/jia2.25079.Peer-Reviewed Original ResearchConceptsHigh-risk behaviorsIllicit drug useHIV-positive menAnal sexDrug useHIV diagnosisSOC participantsVaginal sexPeer counsellingCondomless vaginal sexInsertive anal sexCondomless anal sexTreat analysisHIV transmissionIntervention participantsClinic staffChinese MSMChinese menIntervention studiesLogistic regressionAlcohol useLower likelihoodSexIllicit drugsMen
2017
HIV testing and sexual risks among migrant men who have sex with men: findings from a large cross-sectional study in Beijing, China
Liu Y, Vermund SH, Ruan Y, Liu H, Zhang C, Yin L, Shao Y, Qian HZ. HIV testing and sexual risks among migrant men who have sex with men: findings from a large cross-sectional study in Beijing, China. AIDS Care 2017, 30: 86-94. PMID: 28944685, PMCID: PMC6088860, DOI: 10.1080/09540121.2017.1381331.Peer-Reviewed Original ResearchConceptsLifetime male sexual partnersCondomless receptive anal sexHIV testingMigrant MSMHIV perceptionAnal sexHIV/syphilis infectionOlder ageLarge cross-sectional studyHIV/STI riskLikelihood of syphilisHIV/syphilisInsertive anal sexReceptive anal sexCross-sectional studyMale sexual partnersSyphilis infectionHIV transmissionLocal MSMSTI riskChinese MSMLower oddsEpidemiological studiesSexual partnersRisk profile
2016
Substance use and HIV-risk behaviors among HIV-positive men who have sex with men in China: repeated measures in a cohort study design
Zhang C, Liu Y, Sun X, Wang J, Lu HY, He X, Zhang H, Ruan YH, Shao Y, Vermund SH, Qian HZ. Substance use and HIV-risk behaviors among HIV-positive men who have sex with men in China: repeated measures in a cohort study design. AIDS Care 2016, 29: 644-653. PMID: 27832699, PMCID: PMC5350012, DOI: 10.1080/09540121.2016.1255709.Peer-Reviewed Original ResearchConceptsHIV risk behaviorsCohort study designSubstance useStudy designHIV-positive MSMHIV-positive menGeneralized Estimating Equation modelsFemale sex partnersRapid HIV transmissionMale sexual partnersRigorous study designsSexual risk behaviorsCurrent studySeronegative counterpartsSeropositive menSeropositive partnersHIV transmissionMean agePotential confoundersRisk factorsHigh riskRisk populationsSex partnersUnprotected sexRisk behaviorsIntegrated prevention of mother-to-child HIV transmission services, antiretroviral therapy initiation, and maternal and infant retention in care in rural north-central Nigeria: a cluster-randomised controlled trial
Aliyu MH, Blevins M, Audet CM, Kalish M, Gebi UI, Onwujekwe O, Lindegren ML, Shepherd BE, Wester CW, Vermund SH. Integrated prevention of mother-to-child HIV transmission services, antiretroviral therapy initiation, and maternal and infant retention in care in rural north-central Nigeria: a cluster-randomised controlled trial. The Lancet HIV 2016, 3: e202-e211. PMID: 27126487, PMCID: PMC4852280, DOI: 10.1016/s2352-3018(16)00018-7.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdolescentAdultAnti-HIV AgentsCD4 Lymphocyte CountDelivery of Health Care, IntegratedEarly Intervention, EducationalFamilyFemaleHIV InfectionsHumansInfantInfectious Disease Transmission, VerticalMaleMothersNevirapineNigeriaPregnancyPregnancy Complications, InfectiousPrenatal CareRural PopulationYoung AdultConceptsChild HIV transmissionAntiretroviral therapyStandard of careRural North-Central NigeriaWeeks post partumIntervention groupAntiretroviral prophylaxisEligible womenHIV statusHIV transmissionSecondary level health care facilitiesChild HIV transmission servicesClinical stage 1 diseasePost partumEunice Kennedy Shriver National InstituteMedian CD4 countPMTCT service deliveryAntiretroviral therapy initiationCD4 cell countPrevention of motherStage 1 diseaseUnknown HIV statusElimination of motherNorth Central NigeriaEarly infant diagnosisBarriers and Facilitators of Linkage to and Engagement in HIV Care Among HIV-Positive Men Who Have Sex with Men in China: A Qualitative Study
Liu Y, Osborn CY, Qian HZ, Yin L, Xiao D, Ruan Y, Simoni JM, Zhang X, Shao Y, Vermund SH, Amico KR. Barriers and Facilitators of Linkage to and Engagement in HIV Care Among HIV-Positive Men Who Have Sex with Men in China: A Qualitative Study. AIDS Patient Care And STDs 2016, 30: 70-77. PMID: 26784360, PMCID: PMC4753635, DOI: 10.1089/apc.2015.0296.Peer-Reviewed Original ResearchMeSH KeywordsAdultChinaConfidentialityFearFocus GroupsHealth Knowledge, Attitudes, PracticeHealth ServicesHealth Services AccessibilityHIV InfectionsHomosexuality, MaleHumansInterviews as TopicMalePeer GroupPrejudicePrevalenceQualitative ResearchRisk-TakingSexual PartnersSocial StigmaSocioeconomic FactorsConceptsHIV-positive MSMFacilitators of linkageHIV careAntiretroviral therapyCurrent HIV preventionFree HIV careHIV-positive patientsHIV-positive menHIV care servicesHealth care workersFocus group discussionsContinuum of careHIV transmissionCare interventionsHIV preventionClinic timeCare workersQualitative studyCare servicesKey populationsPsychological burdenMSMCarePeer referralDisclosure concerns
2014
HPTN 071 (PopART): A Cluster-Randomized Trial of the Population Impact of an HIV Combination Prevention Intervention Including Universal Testing and Treatment: Mathematical Model
Cori A, Ayles H, Beyers N, Schaap A, Floyd S, Sabapathy K, Eaton JW, Hauck K, Smith P, Griffith S, Moore A, Donnell D, Vermund SH, Fidler S, Hayes R, Fraser C, . HPTN 071 (PopART): A Cluster-Randomized Trial of the Population Impact of an HIV Combination Prevention Intervention Including Universal Testing and Treatment: Mathematical Model. PLOS ONE 2014, 9: e84511. PMID: 24454728, PMCID: PMC3893126, DOI: 10.1371/journal.pone.0084511.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyArm AHIV incidenceHIV transmissionThree-arm cluster-randomized trialHIV combination prevention interventionsPopulation-level HIV incidenceCombination prevention interventionsCombination prevention packageHPTN 052 trialHPTN 071 (PopART) trialPopulation-level incidenceHIV-positive individualsHeterosexual HIV transmissionUptake of testingNational surveillance dataCluster-randomized trialImpact of treatmentLarge population clustersART retentionHPTN 071Primary endpointArm BPrevention packageControl arm
2013
Sex with Women Among Men Who Have Sex with Men in China: Prevalence and Sexual Practices
Tao J, Ruan Y, Yin L, Vermund SH, Shepherd BE, Shao Y, Qian HZ. Sex with Women Among Men Who Have Sex with Men in China: Prevalence and Sexual Practices. AIDS Patient Care And STDs 2013, 27: 524-528. PMID: 23931683, PMCID: PMC3760059, DOI: 10.1089/apc.2013.0161.Peer-Reviewed Original ResearchConceptsPotential bridge populationPrevalence of HIVSubgroup of menPrevention intervention programsHIV prevention intervention programsSyphilis infectionEligible MSMHIV transmissionAlcohol drinkingAnal sexOlder ageLower educationInsertive roleWomenIntervention programsSexMenBisexual behaviorHIVSignificant differencesStrongest predictorBisexual orientationSexual practicesBridge populationInfectionCan Combination Prevention Strategies Reduce HIV Transmission in Generalized Epidemic Settings in Africa? The HPTN 071 (PopART) Study Plan in South Africa and Zambia
Vermund SH, Fidler SJ, Ayles H, Beyers N, Hayes RJ. Can Combination Prevention Strategies Reduce HIV Transmission in Generalized Epidemic Settings in Africa? The HPTN 071 (PopART) Study Plan in South Africa and Zambia. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2013, 63: s221-s227. PMID: 23764639, PMCID: PMC3739051, DOI: 10.1097/qai.0b013e318299c3f4.Peer-Reviewed Original ResearchConceptsHIV Prevention Trials NetworkHPTN 071 (PopART) studyHPTN 071HIV incidenceHIV transmissionHome-based HIV testingVoluntary medical male circumcisionGeneralized epidemic settingsLinkage of HIVUniversal antiretroviral therapyChild HIV transmissionPrevention of motherHIV viral loadCommunity health workersMedical male circumcisionCommunity-randomized trialIntervention strategiesCombination prevention strategiesAntiretroviral therapyHIV acquisitionSeropositive personsTuberculosis servicesHIV testingViral loadTuberculosis transmissionOptimizing PMTCT service delivery in rural North-Central Nigeria: Protocol and design for a cluster randomized study
Aliyu MH, Blevins M, Audet C, Shepherd BE, Hassan A, Onwujekwe O, Gebi UI, Kalish M, Lindegren ML, Vermund SH, Wester CW. Optimizing PMTCT service delivery in rural North-Central Nigeria: Protocol and design for a cluster randomized study. Contemporary Clinical Trials 2013, 36: 187-197. PMID: 23816493, PMCID: PMC3786261, DOI: 10.1016/j.cct.2013.06.013.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Retroviral AgentsCD4 Lymphocyte CountCost-Benefit AnalysisFamilyFemaleHIV InfectionsHumansInfantInfant, NewbornInfectious Disease Transmission, VerticalMaternal-Child Health CentersMentorsNigeriaPatient SatisfactionPoint-of-Care SystemsPregnancyPrenatal CareResearch DesignRural PopulationSocioeconomic FactorsConceptsAntiretroviral therapyPMTCT servicesChild transmissionHIV service integrationPMTCT service deliveryPMTCT service provisionChild HIV transmissionPrevention of motherCell count testingSimilar resource-limited settingsRural health facilitiesRural North-Central NigeriaResource-limited settingsPatient care responsibilitiesPMTCT careMore HIVHIV infectionCare CD4Cell count resultsHIV transmissionPregnant womenUNAIDS/Health facilitiesHealth providersInfluential community membersTranslation of Biomedical Prevention Strategies for HIV
Vermund SH, Tique JA, Cassell HM, Pask ME, Ciampa PJ, Audet CM. Translation of Biomedical Prevention Strategies for HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2013, 63: s12-s25. PMID: 23673881, PMCID: PMC3725750, DOI: 10.1097/qai.0b013e31829202a2.Peer-Reviewed Original ResearchConceptsPrevention of motherPrevention strategiesClean injection equipmentChild HIV transmissionBiomedical approachBiomedical prevention strategiesRisk of acquisitionHIV prevention strategiesBehavioral risk reductionHigh-prevalence regionsRisk of transmissionCircumcision of menBlood product safetyChild transmissionHIV transmissionAntiretroviral drugsPrevalence regionsHIV preventionHIVFamily planningMore childrenPreventionRisk reductionInjection equipmentSaharan AfricaCombination Prevention: New Hope for Stopping the Epidemic
Vermund SH, Hayes RJ. Combination Prevention: New Hope for Stopping the Epidemic. Current HIV/AIDS Reports 2013, 10: 169-186. PMID: 23456730, PMCID: PMC3642362, DOI: 10.1007/s11904-013-0155-y.Peer-Reviewed Original ResearchMeSH KeywordsAfrica South of the SaharaAnti-HIV AgentsFemaleHealth Knowledge, Attitudes, PracticeHealth PolicyHealth Services AccessibilityHIV InfectionsHumansInfectious Disease Transmission, VerticalMaleMass ScreeningPatient Acceptance of Health CarePregnancyPregnancy Complications, InfectiousRisk Reduction BehaviorSex WorkersSexual BehaviorSocial StigmaSocioeconomic FactorsWorld Health OrganizationConceptsAntiretroviral therapyVoluntary medical male circumcisionCombination prevention approachesOral antiretroviral drugsPre-exposure prophylaxisMedical male circumcisionSuccessful viral suppressionConsistent condom useEvidence-based modalitiesBoost vaccineViral suppressionHIV testingAntiretroviral coverageHIV transmissionAntiretroviral drugsBlood screeningVaginal microbicidesClean needlesInfection controlAdolescent sexual debutTransmission reductionFemale condomMale circumcisionSingle interventionHIV research
2012
HIV knowledge and health-seeking behavior in Zambézia Province, Mozambique
Audet CM, Sidat M, Blevins M, Moon TD, Vergara A, Vermund SH. HIV knowledge and health-seeking behavior in Zambézia Province, Mozambique. SAHARA-J Journal Of Social Aspects Of HIV/AIDS 2012, 9: 41-46. PMID: 23237020, PMCID: PMC3868210, DOI: 10.1080/17290376.2012.665257.Peer-Reviewed Original ResearchConceptsHealth-seeking behaviourHIV transmissionZambézia ProvinceTraditional healersCommunity health care workersGovernment health clinicsCommunity health workersHealth care workersTransmission of HIVHIV prevalence ratesMajority of participantsHIV knowledgeTransmission knowledgeHealth clinicsHIV preventionHealth workersPrevalence ratesPrevention knowledgeMultiple-choice questionnaireSerious illnessHIV educationInfection rateClinical sitesCondom useLevel of knowledge
2011
Experience in international clinical research: the HIV Prevention Trials Network
Sista ND, Karim Q, Hinson K, Donnell D, Eshleman SH, Vermund SH. Experience in international clinical research: the HIV Prevention Trials Network. Clinical Investigation 2011, 1: 1609-1618. PMID: 22348195, PMCID: PMC3281583, DOI: 10.4155/cli.11.156.Peer-Reviewed Original ResearchHIV Prevention Trials NetworkCombination antiretroviral therapyHIV transmissionClinical trialsPrevention strategiesTrials NetworkHPTN 052 studyOpiate agonist therapySerodiscordant sexual partnersHIV testing ratesPre-exposure prophylaxisHIV prevention strategiesPivotal efficacy trialsInjection drug usersHigh-risk behaviorsPublic health policyAgonist therapyAntiretroviral therapyHIV seroconversionInfected partnerMiddle-income countriesTrial feasibilityAntiretroviral drugsHPTN 068Efficacy trials
2010
Combination HIV Prevention: Significance, Challenges, and Opportunities
Kurth AE, Celum C, Baeten JM, Vermund SH, Wasserheit JN. Combination HIV Prevention: Significance, Challenges, and Opportunities. Current HIV/AIDS Reports 2010, 8: 62-72. PMID: 20941553, PMCID: PMC3036787, DOI: 10.1007/s11904-010-0063-3.Peer-Reviewed Original ResearchConceptsHIV prevention strategiesHIV transmissionPrevention strategiesPopulation-level HIV transmissionBehavioral risk reductionEvidence-based strategiesNumber of interventionsAntiretroviral medicationsHIV serostatusPrevention packageUninfected personsEpidemiologic profileHIV pandemicMale circumcisionNeedle exchangeEffective interventionsTarget populationInterventionRisk reductionMeasurable reductionPopulation levelDiverse subgroupsMedicationsSerostatusHIV