2024
Maternal and Newborn Outcomes of SARS-CoV-2/COVID-19 and Pregnancy: Parallels and Contrasts with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome
Li D, Zhang J, Zhang X, Chang Y, Vermund S. Maternal and Newborn Outcomes of SARS-CoV-2/COVID-19 and Pregnancy: Parallels and Contrasts with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome. Medical Research Archives 2024, 12: 10.18103/mra.v12i4.5205. PMID: 39118854, PMCID: PMC11309002, DOI: 10.18103/mra.v12i4.5205.Peer-Reviewed Original ResearchHuman immunodeficiency virus/acquired immunodeficiency syndromeHuman immunodeficiency virusHuman immunodeficiency virus-infected womenAdherence to antiretroviral therapyNeonatal outcomesImmunodeficiency virusImmunodeficiency syndromeIntensive care unitAntiretroviral therapySARS-CoV-2Maternal mortalityRisk of mother-to-child transmissionVertical transmissionVertical transmission of human immunodeficiency virusClinical managementTransmission of human immunodeficiency virusImpact of human immunodeficiency virusIncreased risk of maternal mortalityHuman immunodeficiency virus controlPoor adherence to antiretroviral therapySARS-CoV-2 vertical transmissionVertical transmission of SARS-CoV-2Pregnant individualsMother-to-child transmissionNeonatal intensive care unit
2023
Combination HIV prevention during pregnancy and the post‐partum period in Malawi and Zambia: a mathematical modelling analysis
Powers K, Mutale W, Rosenberg N, Graybill L, Mollan K, Freeborn K, Saidi F, Maman S, Mulenga P, Jahn A, Nyirenda R, Stringer J, Vermund S, H. B. Combination HIV prevention during pregnancy and the post‐partum period in Malawi and Zambia: a mathematical modelling analysis. Journal Of The International AIDS Society 2023, 26: e26128. PMID: 37403422, PMCID: PMC10320044, DOI: 10.1002/jia2.26128.Peer-Reviewed Original ResearchConceptsFemale HIV transmissionMaternal HIV acquisitionMaternal HIV incidenceHIV prevention strategiesPost-partum periodAntiretroviral therapyHIV transmissionMale partnersHIV acquisitionHIV incidenceANC patientsPrevention strategiesCombination HIV prevention strategiesCombination HIV prevention interventionSuppressive antiretroviral therapyPre-exposure prophylaxisVertical HIV transmissionAntenatal care programsCombination HIV preventionHIV prevention interventionsANC initiationART initiationUnsuppressed HIVIncident infectionsUndiagnosed HIVHigh-Level Drug-Resistant Mutations among HIV-1 Subtype A6 and CRF02_AG in Kazakhstan
Sanaubarova A, Pujol-Hodge E, Dzissyuk N, Lemey P, Vermund S, Brown A, Ali S. High-Level Drug-Resistant Mutations among HIV-1 Subtype A6 and CRF02_AG in Kazakhstan. Viruses 2023, 15: 1407. PMID: 37515095, PMCID: PMC10384832, DOI: 10.3390/v15071407.Peer-Reviewed Original ResearchConceptsAntiretroviral therapySubtype A6Drug-resistant mutationsDrug resistanceEffective antiretroviral therapySuppressive antiretroviral therapyAntiretroviral drug resistanceDrug resistance monitoringHigh-level drug resistanceDrug regimensHIV incidenceHIV epidemicHIV-1Sustained transmissionMolecular epidemiologySubtypesPLHIVHIVG190SDifferent mutational pathwaysMutationsK101ED67NHigh levelsA62V
2022
COVID-19 Clinical Presentation Among HIV-Infected Persons in China: A Systematic Review
Huang D, Zunong J, Li M, Li D, Gong J, Vermund SH, Hu Y. COVID-19 Clinical Presentation Among HIV-Infected Persons in China: A Systematic Review. Current HIV/AIDS Reports 2022, 19: 167-176. PMID: 35394249, PMCID: PMC8990500, DOI: 10.1007/s11904-022-00606-0.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyCOVID-19 clinical severityCOVID-19 clinical presentationCOVID-19Undetectable viral loadAsymptomatic COVID-19Severe COVID-19Last clinical visitCase series/reportsCase fatality rateCOVID-19 prognosisLate antiretroviral therapyIL-6 resultsSARS-CoV-2COVID-19 diagnosisMedian CD4Gastrointestinal symptomsHIV infectionMedian ageRespiratory distressClinical featuresClinical presentationClinical visitsViral loadClinical detailsTreatment outcomes of HIV patients with hepatitis B and C virus co-infections in Southwest China: an observational cohort study
Jia J, Zhu Q, Deng L, Lan G, Johnson A, Chen H, Shen Z, Li J, Xing H, Ruan Y, Li J, Lu H, Vermund SH, Zhu J, Qian HZ. Treatment outcomes of HIV patients with hepatitis B and C virus co-infections in Southwest China: an observational cohort study. Infectious Diseases Of Poverty 2022, 11: 7. PMID: 34986877, PMCID: PMC8734096, DOI: 10.1186/s40249-021-00921-5.Peer-Reviewed Original ResearchConceptsHepatitis B virusHepatitis C virusAntiretroviral therapyHigh mortalityHCV coinfectionC virusNational Free Antiretroviral Treatment ProgramHBV co-infected patientsHBV/HCV coinfectionRetrospective cohort study analysisEffect of ARTCohort study analysisObservational cohort studyAntiretroviral treatment programOverall mortality rateProportional hazards modelTreatment attrition rateCause deathHCV-coHIV patientsBaseline infectionCohort studyHBV-HCVHepatitis BHepatitis treatment
2020
Coinfection With HIV and SARS-CoV-2 in Wuhan, China: A 12-Person Case Series
Hu Y, Ma J, Huang H, Vermund SH. Coinfection With HIV and SARS-CoV-2 in Wuhan, China: A 12-Person Case Series. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2020, 85: 10.1097/qai.0000000000002424. PMID: 32568771, PMCID: PMC7446977, DOI: 10.1097/qai.0000000000002424.Peer-Reviewed Original ResearchConceptsAntiretroviral therapySARS-CoV-2Clinical improvementCase seriesLong-term antiretroviral therapyMild COVID-19 symptomsCOVID-19 coinfectionAcute COVID-19COVID-19 symptomsYears of ageCOVID-19Health care servicesPossible COVID-19 casesCoinfected PersonsAntiretroviral medicationsMedian ageIntensive careCOVID-19 casesClinical prognosisFavorable outcomeSevere symptomsAdditional casesCare servicesHIVInformed consent
2019
Attrition of HIV-positive children from HIV services in low and middle-income countries.
Carlucci JG, Liu Y, Clouse K, Vermund SH. Attrition of HIV-positive children from HIV services in low and middle-income countries. AIDS 2019, 33: 2375-2386. PMID: 31764102, PMCID: PMC6905128, DOI: 10.1097/qad.0000000000002366.Peer-Reviewed Original ResearchConceptsHIV-positive childrenHIV servicesAntiretroviral therapyMiddle-income countriesEarly ART initiationPatient support servicesOptimal health outcomesMeta-regression analysisART initiationLTFU definitionStudy eligibilityMagnitude of attritionEligibility criteriaHealth outcomesSystematic reviewRandom-effects meta-analytic methodsOverall attritionMeta-analytic methodsMultidatabase searchData extractionVulnerable populationsImplementation researchMonthsMost attritionLTFUInterventions to improve the HIV continuum of care in China
Zhang X, Wang N, Vermund SH, Zou H, Li X, Zhang F, Qian HZ. Interventions to improve the HIV continuum of care in China. Current HIV/AIDS Reports 2019, 16: 448-457. PMID: 31776975, PMCID: PMC10767704, DOI: 10.1007/s11904-019-00469-y.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyHIV continuumHIV epidemicPublic health intervention programsFree ART programHIV sexual transmissionHIV testing campaignsFormer plasma donorsPurpose of ReviewToHealth intervention programsTwo-thirdsViral suppressionHeterosexual transmissionPediatric mortalitySexual transmissionRisk groupsMore infectionsPlasma donorsRecent FindingsTheIntervention programsYoung menCareHIVHeterosexual menLower ratesTreatment as Prevention: Concepts and Challenges for Reducing HIV Incidence
Brault MA, Spiegelman D, Hargreaves J, Nash D, Vermund SH. Treatment as Prevention: Concepts and Challenges for Reducing HIV Incidence. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2019, 82: s104-s112. PMID: 31658196, PMCID: PMC6820703, DOI: 10.1097/qai.0000000000002168.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyHIV transmissionHIV plasma loadReducing HIV IncidenceHIV prevention trialsCommunity-level interventionsDeployable vaccineViral suppressionHIV testingHIV incidencePrevention trialsUninfected personsChronic conditionsHIV investmentsEarly treatmentTreat strategySexual partnersViral expressionTransmission riskHIVTrialsTreatmentInconsistent findingsPreventionSaharan Africa
2018
Exploration of Implementation Patterns and Content from a Text-Based Outreach Intervention Clinical Trial for Newly Diagnosed, HIV-Positive MSM in Beijing, China
Knudson A, Shaw S, Yin L, Xiao D, Qian HZ, Sullivan S, Liu H, Ruan Y, Shao Y, Vermund SH, Amico KR. Exploration of Implementation Patterns and Content from a Text-Based Outreach Intervention Clinical Trial for Newly Diagnosed, HIV-Positive MSM in Beijing, China. AIDS And Behavior 2018, 23: 1158-1165. PMID: 30288683, PMCID: PMC6566097, DOI: 10.1007/s10461-018-2287-y.Peer-Reviewed Original ResearchPartners-based HIV treatment for seroconcordant couples attending antenatal and postnatal care in rural Mozambique: A cluster randomized trial protocol
Audet CM, Graves E, Barreto E, De Schacht C, Gong W, Shepherd BE, Aboobacar A, Gonzalez-Calvo L, Alvim MF, Aliyu MH, Kipp AM, Jordan H, Amico KR, Diemer M, Ciaranello A, Dugdale C, Vermund SH, Van Rompaey S. Partners-based HIV treatment for seroconcordant couples attending antenatal and postnatal care in rural Mozambique: A cluster randomized trial protocol. Contemporary Clinical Trials 2018, 71: 63-69. PMID: 29879469, PMCID: PMC6067957, DOI: 10.1016/j.cct.2018.05.020.Peer-Reviewed Original ResearchConceptsChild transmissionSeroconcordant couplesMale partnersResource-limited rural settingsElimination of motherRoutine clinical dataUptake of servicesClinical trial designMale partner approvalAntiretroviral therapyHIV careAntenatal careRural MozambiqueHIV servicesPostnatal carePregnant womenHIV treatmentTrial protocolClinical dataHealth facilitiesTrial designHIVNewborn childrenPartner approvalEngagement interventionsShifting the HIV Paradigm from Care to Cure: Proceedings from the Caribbean Expert Summit in Barbados, August 2017
Landis R, Abayomi E, Bain B, Greene E, Janossy G, Joseph P, Kerrigan D, McCoy JP, Nunez C, O'Gorman M, Pastoors A, Parekh B, Quimby K, Quinn TC, Robertson K, Thomas R, van Gorp E, Vermund SH, Wilson V. Shifting the HIV Paradigm from Care to Cure: Proceedings from the Caribbean Expert Summit in Barbados, August 2017. AIDS Research And Human Retroviruses 2018, 34: 561-569. PMID: 29732897, PMCID: PMC6053839, DOI: 10.1089/aid.2017.0310.Peer-Reviewed Original ResearchConceptsJoint United Nations ProgrammePublic health benefitsHIV/AIDSPublic health messagingNew medical treatmentsAntiretroviral therapyHIV diseaseUNAIDS 90United Nations ProgrammeMedical treatmentHealth messagingHealth benefitsNations ProgrammeDiseaseInternational expertsCareHealthcare professionsCritical appraisalTreatmentPersistent fearSpirit of optimismStigmaHIVTherapyCommunity level
2017
Differences in health-related quality of life between HIV-positive and HIV-negative people in Zambia and South Africa: a cross-sectional baseline survey of the HPTN 071 (PopART) trial
Thomas R, Burger R, Harper A, Kanema S, Mwenge L, Vanqa N, Bell-Mandla N, Smith P, Floyd S, Bock P, Ayles H, Beyers N, Donnell D, Fidler S, Hayes R, Hauck K, Team H, Hargreaves J, Watson-Jones D, Godfrey-Faussett P, Cori A, Pickles M, Mandla N, Yang B, James A, Vermaak R, Makola N, Hoddinott G, Naidoo V, Bond V, Simwinga M, Mwinga A, Kosloff B, Limbada M, Bwalya J, Ngulube C, Fraser C, Eshleman S, Agyei Y, Cummings V, Catalano D, Emel L, Bunts L, Noble H, Burns D, Kouda A, Sista N, Moore A, White R, Headen T, Miller E, Hinson K, Vermund S, Barnes M, Horn L, Mwango A, Baldwin M, Wolf S, Hughes E. Differences in health-related quality of life between HIV-positive and HIV-negative people in Zambia and South Africa: a cross-sectional baseline survey of the HPTN 071 (PopART) trial. The Lancet Global Health 2017, 5: e1133-e1141. PMID: 28964756, PMCID: PMC5640509, DOI: 10.1016/s2214-109x(17)30367-4.Peer-Reviewed Original ResearchConceptsHIV-negative peopleHIV-positive individualsHIV-negative individualsAntiretroviral therapyHealth-related qualityHIV careHRQoL scoresHIV statusHerpes simplex virus type-2 statusNational InstituteHPTN 071 (PopART) studyHPTN 071 (PopART) trialLaboratory-confirmed HIVType 2 statusCross-sectional baseline surveyLarge cross-sectional surveyRecreational drug useCross-sectional surveyPresident's Emergency PlanGeneral population sampleHRQoL informationBetter HRQoLHIV-negativeHIV progressionHRQoL dataAssociation Between Depression and Antiretroviral Therapy Use Among People Living with HIV: A Meta-analysis
Tao J, Vermund SH, Qian HZ. Association Between Depression and Antiretroviral Therapy Use Among People Living with HIV: A Meta-analysis. AIDS And Behavior 2017, 22: 1542-1550. PMID: 28439754, PMCID: PMC7942230, DOI: 10.1007/s10461-017-1776-8.Peer-Reviewed Original ResearchConceptsAntiretroviral therapySubgroup analysisEligible studiesART useAntiretroviral therapy useProspective study designSmall-study effectsPooled sample sizeOdds ratio estimatesPublication bias analysesTherapy usePooled prevalenceEgger's testConference abstractsFunnel plotPLHIVElectronic databasesMeta-AnalysisPublication biasStudy designDepressionModerator analysesHIVBias analysisRatio estimatesAdapting an adherence support workers intervention: engaging traditional healers as adherence partners for persons enrolled in HIV care and treatment in rural Mozambique
Audet CM, Salato J, Vermund SH, Amico KR. Adapting an adherence support workers intervention: engaging traditional healers as adherence partners for persons enrolled in HIV care and treatment in rural Mozambique. Implementation Science 2017, 12: 50. PMID: 28407813, PMCID: PMC5390357, DOI: 10.1186/s13012-017-0582-z.Peer-Reviewed Original ResearchConceptsCommunity health workersAntiretroviral therapyWorker interventionTraditional healersHealth workersHealth systemAllopathic health systemEvidence-informed interventionsLow-literacy populationsHIV careHIV diagnosisRural MozambiquePatient adherenceHIV epidemicHealth facilitiesClinical careHealthcare providersHealth workforceHIVTraditional treatmentCommunity-based activitiesInterventionTraditional medicineCareSuccessful program implementationMobility and Clinic Switching Among Postpartum Women Considered Lost to HIV Care in South Africa
Clouse K, Vermund SH, Maskew M, Lurie MN, MacLeod W, Malete G, Carmona S, Sherman G, Fox MP. Mobility and Clinic Switching Among Postpartum Women Considered Lost to HIV Care in South Africa. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2017, 74: 383-389. PMID: 28225717, PMCID: PMC5324708, DOI: 10.1097/qai.0000000000001284.Peer-Reviewed Original ResearchConceptsHIV careNational Health Laboratory Service databaseLow CD4 cell countsNational Antiretroviral Therapy ProgramCD4 cell countObservational cohort studyAntiretroviral therapy programsAntiretroviral therapyCohort studyPostpartum womenPublic clinicsService databaseCell countTherapy programCareWomenLTFUClinicOne-thirdDaysPatientsPregnancyTherapyThe Continuum of HIV Care in the Urban United States: Black Men Who Have Sex With Men (MSM) Are Less Likely Than White MSM to Receive Antiretroviral Therapy
Vermund SH. The Continuum of HIV Care in the Urban United States: Black Men Who Have Sex With Men (MSM) Are Less Likely Than White MSM to Receive Antiretroviral Therapy. The Journal Of Infectious Diseases 2017, 216: 790-794. PMID: 28368523, PMCID: PMC5853891, DOI: 10.1093/infdis/jix009.Peer-Reviewed Original ResearchImpact of Depression and Anxiety on Initiation of Antiretroviral Therapy Among Men Who Have Sex with Men with Newly Diagnosed HIV Infections in China
Tao J, Vermund SH, Lu H, Ruan Y, Shepherd BE, Kipp AM, Amico KR, Zhang X, Shao Y, Qian HZ. Impact of Depression and Anxiety on Initiation of Antiretroviral Therapy Among Men Who Have Sex with Men with Newly Diagnosed HIV Infections in China. AIDS Patient Care And STDs 2017, 31: 96-104. PMID: 28170305, PMCID: PMC5312604, DOI: 10.1089/apc.2016.0214.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyART initiationHIV diagnosisHIV infectionDepression scoresEarly ART initiationNational ART databaseNew HIV diagnosesImpact of depressionEffect of depressionProspective cohortBorderline depressionCox regressionHADS scoresBaseline prevalenceEligible participantsHospital AnxietyBorderline anxietyDepression ScaleDoctor's adviceChinese MSMChinese menSymptom severityHIVAnxiety scoresEffects of depression and anxiety on antiretroviral therapy adherence among newly diagnosed HIV-infected Chinese MSM
Tao J, Qian HZ, Kipp AM, Ruan Y, Shepherd BE, Amico KR, Shao Y, Lu H, Vermund SH. Effects of depression and anxiety on antiretroviral therapy adherence among newly diagnosed HIV-infected Chinese MSM. AIDS 2017, 31: 401-406. PMID: 27677168, PMCID: PMC5233466, DOI: 10.1097/qad.0000000000001287.Peer-Reviewed Original ResearchConceptsImperfect ART adherenceEffect of depressionART adherenceAntiretroviral therapyHIV infectionChinese MSMHIV treatment outcomesAntiretroviral therapy adherenceEnd of studyMixed-effects logistic regressionHIV diagnosisOne-unit increaseProspective studyTherapy adherenceHospital AnxietyRisk factorsTreatment outcomesDepression ScaleSignificant associationIntensive interventionLogistic regressionMSMAnxiety scoresAdherenceInfectionMortality in Children with Human Immunodeficiency Virus Initiating Treatment: A Six-Cohort Study in Latin America
Luque MT, Jenkins CA, Shepherd BE, Padgett D, Rouzier V, Succi RCM, Machado DM, McGowan CC, Vermund SH, Pinto JA. Mortality in Children with Human Immunodeficiency Virus Initiating Treatment: A Six-Cohort Study in Latin America. The Journal Of Pediatrics 2017, 182: 245-252.e1. PMID: 28081884, PMCID: PMC5328796, DOI: 10.1016/j.jpeds.2016.12.034.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveCause of DeathChildChild, PreschoolCohort StudiesConfidence IntervalsDatabases, FactualDose-Response Relationship, DrugDrug Administration ScheduleFemaleHIV InfectionsHumansIncidenceLatin AmericaMaleProportional Hazards ModelsRetrospective StudiesRisk AssessmentSeverity of Illness IndexSurvival AnalysisConceptsCombination antiretroviral therapyYears of ageCART initiationGreater riskCox proportional hazards modelAntiretroviral therapy-naïveMedian CD4 countRetrospective cohort studyProportional hazards modelCumulative mortality incidenceSouth America networkProbability of deathInitiating treatmentMedian CD4Antiretroviral therapyCause mortalityCD4 countTherapy-naïveCohort studyCumulative incidenceHIV epidemiologyPediatric careMortality incidenceHazards modelRegimens