2018
Excess glucose induce trophoblast inflammation and limit cell migration through HMGB1 activation of Toll‐Like receptor 4
Heim KR, Mulla MJ, Potter JA, Han CS, Guller S, Abrahams VM. Excess glucose induce trophoblast inflammation and limit cell migration through HMGB1 activation of Toll‐Like receptor 4. American Journal Of Reproductive Immunology 2018, 80: e13044. PMID: 30175447, DOI: 10.1111/aji.13044.Peer-Reviewed Original ResearchMeSH KeywordsAlarminsCell LineCell MovementFemaleGlycyrrhizic AcidHMGB1 ProteinHumansHyperglycemiaInflammationInterleukin-1betaInterleukin-8Pre-EclampsiaPregnancyRiskSignal TransductionToll-Like Receptor 4TrophoblastsVascular Endothelial Growth Factor Receptor-1ConceptsToll-like receptor 4High mobility group box 1Damage-associated molecular patternsHMGB1 activationIL-1βIL-8Trophoblast responsesReceptor 4Human first trimester trophoblast cell lineFirst trimester trophoblast cell lineInflammatory IL-8Risk of preeclampsiaGroup box 1Uric acidIL-1β responseExcess glucoseTrophoblast cell lineCell migrationTrophoblast inflammationPregnancy outcomesTLR4 antagonistLPS-RSIL-6SFlt-1HMGB1 inhibitor
2017
Low molecular weight heparin and aspirin exacerbate human endometrial endothelial cell responses to antiphospholipid antibodies
Quao ZC, Tong M, Bryce E, Guller S, Chamley LW, Abrahams VM. Low molecular weight heparin and aspirin exacerbate human endometrial endothelial cell responses to antiphospholipid antibodies. American Journal Of Reproductive Immunology 2017, 79 PMID: 29135051, PMCID: PMC5728699, DOI: 10.1111/aji.12785.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, AntiphospholipidAntiphospholipid SyndromeAspirinBeta 2-Glycoprotein ICells, CulturedChemokinesDisease ProgressionDrug Therapy, CombinationEndometriumEndothelial CellsFemaleHeparin, Low-Molecular-WeightHumansMembrane ProteinsNeovascularization, PhysiologicPregnancyPregnancy ComplicationsTrophoblastsVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1ConceptsLow molecular weight heparinHuman endometrial endothelial cellsMolecular weight heparinUterine endotheliumAntiphospholipid antibodiesWeight heparinInfluence of LMWHLow dose low molecular weight heparinAnti-angiogenic sFlt-1Chemokine MCP-1Endometrial endothelial cellsEffects of aPLSFlt-1 releaseAngiogenic factor secretionObstetric APSPregnancy complicationsControl IgGChemokine profilesEndothelium dysfunctionChemokine secretionPro-angiogenic VEGFCombination therapySFlt-1Impaired placentationMCP-1
2007
Contrasting effects of chronic hypoxia and nitric oxide synthase inhibition on circulating angiogenic factors in a rat model of growth restriction
Bahtiyar MO, Buhimschi C, Ravishankar V, Copel J, Norwitz E, Julien S, Guller S, Buhimschi IA. Contrasting effects of chronic hypoxia and nitric oxide synthase inhibition on circulating angiogenic factors in a rat model of growth restriction. American Journal Of Obstetrics And Gynecology 2007, 196: 72.e1-72.e6. PMID: 17240241, DOI: 10.1016/j.ajog.2006.07.048.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChronic DiseaseDisease Models, AnimalEnzyme InhibitorsFemaleFetal Growth RetardationHypoxiaNG-Nitroarginine Methyl EsterNitric Oxide SynthasePlacenta Growth FactorPregnancyPregnancy ProteinsRatsRats, Sprague-DawleyVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth FactorsConceptsVascular endothelial growth factorL-NAMESerum levelsChronic hypoxiaSoluble fms-like tyrosine kinase-1Nitro-L-arginine methyl esterFms-like tyrosine kinase-1Adult Sprague-Dawley ratsGrowth factorMaternal serum levelsFree serum levelsIntrauterine growth restrictionOnset of laborPlacental growth factorTyrosine kinase-1Subcutaneous osmotic pumpsSprague-Dawley ratsNitric oxide inhibitionEndothelial growth factorNonpregnant controlsSFlt-1Growth restrictionHypoxic chamberMaternal bloodOxide inhibition
2006
Fractional Excretion of Angiogenic Factors in Women With Severe Preeclampsia
Buhimschi CS, Magloire L, Funai E, Norwitz ER, Kuczynski E, Martin R, Richman S, Guller S, Lockwood CJ, Buhimschi IA. Fractional Excretion of Angiogenic Factors in Women With Severe Preeclampsia. Obstetrics And Gynecology 2006, 107: 1103-1113. PMID: 16648417, DOI: 10.1097/01.aog.0000207698.74104.4f.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlbuminuriaCase-Control StudiesCreatinineFemaleHumansPlacenta Growth FactorPre-EclampsiaPregnancyPregnancy ProteinsSerum AlbuminSeverity of Illness IndexVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1ConceptsVascular endothelial growth factorPlacental growth factorEndothelial growth factorProtein/creatinine ratioTotal protein/creatinine ratioPreeclamptic womenFractional excretionSevere preeclampsiaCreatinine ratioSFlt-1Angiogenic factorsGrowth factorPregnant controlsSoluble fms-like tyrosine kinase-1Serum placental growth factor levelsUrinary vascular endothelial growth factorFms-like tyrosine kinase-1Placental growth factor levelsHealthy pregnant controlsHealthy pregnant womenDisease clinical manifestationsGrowth factor levelsTyrosine kinase-1Preeclamptic groupRenal production
2005
Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia
Buhimschi CS, Norwitz ER, Funai E, Richman S, Guller S, Lockwood CJ, Buhimschi IA. Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia. American Journal Of Obstetrics And Gynecology 2005, 192: 734-741. PMID: 15746665, DOI: 10.1016/j.ajog.2004.12.052.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersFemaleHumansHypertensionMembrane ProteinsPre-EclampsiaPregnancyPregnancy Complications, CardiovascularProspective StudiesProteinsProteinuriaSeverity of Illness IndexUric AcidVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1ConceptsVascular endothelial growth factorSevere preeclampsiaHypertensive disordersHypertensive womenUrinary levelsUrinary outputSFlt-1Soluble fms-like tyrosine kinase-1Fms-like tyrosine kinase-1Antiangiogenic factors sFlt-1Growth factorSFlt-1 concentrationsHealthy pregnant controlsPlacental growth factorTime of enrollmentTyrosine kinase-1Urinary protein measurementsEndothelial growth factorClinical preeclampsiaProteinuric womenPlGF levelsNonpregnant womenPlGF ratioPregnant controlsGestational age