2020
Zika Virus-Infected Decidual Cells Elicit a Gestational Age-Dependent Innate Immune Response and Exaggerate Trophoblast Zika Permissiveness: Implication for Vertical Transmission.
Guzeloglu-Kayisli O, Guo X, Tang Z, Semerci N, Ozmen A, Larsen K, Mutluay D, Guller S, Schatz F, Kayisli UA, Lockwood CJ. Zika Virus-Infected Decidual Cells Elicit a Gestational Age-Dependent Innate Immune Response and Exaggerate Trophoblast Zika Permissiveness: Implication for Vertical Transmission. The Journal Of Immunology 2020, 205: 3083-3094. PMID: 33139490, DOI: 10.4049/jimmunol.2000713.Peer-Reviewed Original ResearchConceptsHuman decidual cellsDecidual cellsZika virusViral attachment factorsTerm decidual stromal cellsVertical transmissionDecidual cell supernatantsTerm decidual cellsInnate immune response genesInnate immune responsivenessExact pathogenic mechanismDecidual stromal cellsHuman first trimesterInnate immune responseSevere fetal defectsImmune response genesFetal sequelaeGestational ageFirst trimesterPlacental transmissionZIKV infectionCytotrophoblast culturesImmune responsivenessZika infectionLate pregnancy
2019
IL‐10 to TNFα ratios throughout early first trimester can discriminate healthy pregnancies from pregnancy losses
Kaislasuo J, Simpson S, Petersen JF, Peng G, Aldo P, Lokkegaard E, Paidas M, Pal L, Guller S, Mor G. IL‐10 to TNFα ratios throughout early first trimester can discriminate healthy pregnancies from pregnancy losses. American Journal Of Reproductive Immunology 2019, 83: e13195. PMID: 31585488, PMCID: PMC8295882, DOI: 10.1111/aji.13195.Peer-Reviewed Original ResearchConceptsWeeks of gestationIL-10Pregnancy lossHealthy pregnancyFirst trimesterTNFα ratioNormal pregnancySymptoms of miscarriageIL-10 concentrationsProspective longitudinal cohortEarly first trimesterFirst trimester lossImplantation dayIVF cohortImmunological balanceSerum levelsViable pregnancySerial bloodGestation weeksTNFα concentrationsEarly immunomodulationLongitudinal cohortEmbryo implantationPregnancySingle time point