2018
Glucocorticoid signaling regulates cell invasion and migration in the human first‐trimester trophoblast cell line Sw.71
Kisanga EP, Tang Z, Guller S, Whirledge S. Glucocorticoid signaling regulates cell invasion and migration in the human first‐trimester trophoblast cell line Sw.71. American Journal Of Reproductive Immunology 2018, 80: e12974. PMID: 29774963, DOI: 10.1111/aji.12974.Peer-Reviewed Original ResearchConceptsGene expression profilesSERPINE1 promoterPolymerase IITranscriptional regulationGlucocorticoid receptorCell movementTranscriptional profilesGlucocorticoid treatmentExpression profilesMicroarray analysisStress responseCell invasionPrimary mediatorPathogenesis of preeclampsiaCell proliferationEffects of glucocorticoidsExtravillous trophoblast functionsGlucocorticoid signalingSynthetic glucocorticoid dexamethasoneGenesTrophoblast functionsAdrenal axisInvasionTrophoblast tissueGlucocorticoid dexamethasone
1994
Developmental regulation of glucocorticoid-mediated effects on extracellular matrix protein expression in the human placenta
Guller S, Markiewicz L, Wozniak R, Burnham J, Wang E, Kaplan P, Lockwood C. Developmental regulation of glucocorticoid-mediated effects on extracellular matrix protein expression in the human placenta. Endocrinology 1994, 134: 2064-2071. DOI: 10.1210/en.134.5.2064.Peer-Reviewed Original ResearchEffects of glucocorticoidsTerm cellsLevels of glucocorticoidsTrimester cellsDexamethasone treatmentTrimester of human pregnancyControl levelsGlucocorticoid responseSeparation of placentaTreatment of cytotrophoblastsLevels of hCGControl valuesIncreased glucocorticoid responseHuman first trimesterLow levels of glucocorticoidsGlucocorticoid-mediated effectsLevels of FN mRNARates of FNElevated levels of glucocorticoidsExtracellular matrix protein expressionLevels of FNCytotrophoblast culturesReduced glucocorticoid responsivenessHuman pregnancyFirst-trimester
1993
Glucocorticoid suppression of human placental fibronectin expression: implications in uterine-placental adherence
Guller S, Wozniak R, Krikun G, Burnham J, Kaplan P, Lockwood C. Glucocorticoid suppression of human placental fibronectin expression: implications in uterine-placental adherence. Endocrinology 1993, 133: 1139-1146. DOI: 10.1210/en.133.3.1139.Peer-Reviewed Original ResearchTreatment of cytotrophoblastsIncreased levels of glucocorticoidsEffects of glucocorticoidsHuman term placentaLevels of glucocorticoidsPlacental functionExtracellular matrix protein synthesisHuman parturitionAssociated with parturitionTerm placentaMultiple extracellular matrix proteinsPlacental fibronectinDexamethasone treatmentCytotrophoblastMatrix protein synthesisDexamethasoneGlucocorticoidExtracellular matrix proteinsCell-associated materialImmunoprecipitation studiesOnfFNLevels of total proteinMessenger RNANorthern blottingOncofetal epitope