The role of angiogenic factors in fibroid pathogenesis: potential implications for future therapy
Tal R, Segars JH. The role of angiogenic factors in fibroid pathogenesis: potential implications for future therapy. Human Reproduction Update 2013, 20: 194-216. PMID: 24077979, PMCID: PMC3922145, DOI: 10.1093/humupd/dmt042.Peer-Reviewed Original ResearchMeSH KeywordsAngiogenesis Inducing AgentsAngiogenesis InhibitorsAntineoplastic AgentsFemaleHumansIntercellular Signaling Peptides and ProteinsLeiomyomaMyometriumNeovascularization, PathologicUterine NeoplasmsUterusVascular Endothelial Growth FactorsConceptsUterine artery embolizationEpidermal growth factorAbnormal vasculatureAngiogenic growth factorsGrowth factorUterine fibroidsAnti-angiogenic treatment strategiesVascular endothelial growth factorPlatelet-derived growth factorBasic fibroblast growth factorEndothelial growth factorAnti-angiogenic mechanismGrowth factor dysregulationFibroblast growth factorArtery embolizationGnRH agonistTreatment strategiesBenign tumorsMultiple growth factorsCommon treatmentFibroid growthFuture therapiesReduced vascularizationVascular supplyLeiomyoma tissue