2012
The Role of Hypoxia and Hypoxia-Inducible Factor-1Alpha in Preeclampsia Pathogenesis
Tal R. The Role of Hypoxia and Hypoxia-Inducible Factor-1Alpha in Preeclampsia Pathogenesis. Biology Of Reproduction 2012, 87: 134, 1-8. PMID: 23034156, DOI: 10.1095/biolreprod.112.102723.Peer-Reviewed Original ResearchConceptsSoluble fms-like tyrosine kinase-1Pathogenesis of preeclampsiaRole of hypoxiaSoluble endoglinAngiotensin II receptor type IFms-like tyrosine kinase-1Spiral artery remodelingTyrosine kinase-1Hypoxia-inducible factor-1alphaReceptor type IHypoxia-inducible factorMaternal manifestationsPutative culpritsFetal morbiditySymptomatic therapyArtery remodelingPlacental hypoxiaCascade of eventsEndothelin-1Preeclampsia pathogenesisDisease manifestationsPossible molecular linkPreeclampsiaEffective preventionPathogenesis
2008
Endothelial-targeted gene transfer of hypoxia-inducible factor-1alpha augments ischemic neovascularization following systemic administration.
Tal R, Shaish A, Rofe K, Feige E, Varda-Bloom N, Afek A, Barshack I, Bangio L, Hodish I, Greenberger S, Peled M, Breitbart E, Harats D. Endothelial-targeted gene transfer of hypoxia-inducible factor-1alpha augments ischemic neovascularization following systemic administration. Molecular Therapy 2008, 16: 1927-36. PMID: 18797451, DOI: 10.1038/mt.2008.191.Peer-Reviewed Original ResearchConceptsHypoxia-inducible factor-1alphaSystemic administrationTherapeutic efficacyProangiogenic gene therapyFactor-1alphaSystemic side effectsEnhanced blood perfusionRoute of administrationTail vein administrationHindlimb ischemia modelMouse hindlimb ischemia modelMurine preproendothelin-1 promoterClinical outcomesPreproendothelin-1 promoterC57BL/6 miceIschemic neovascularizationIntravenous routeIschemic muscleIntraarterial routeIschemia modelCapillary densityIschemic regionSide effectsSystemic toxicityTherapeutic angiogenesis