Mechanisms of chorioamnionitis‐associated preterm birth: interleukin‐1β inhibits progesterone receptor expression in decidual cells
Guzeloglu-Kayisli O, Kayisli UA, Semerci N, Basar M, Buchwalder LF, Buhimschi CS, Buhimschi IA, Arcuri F, Larsen K, Huang JS, Schatz F, Lockwood CJ. Mechanisms of chorioamnionitis‐associated preterm birth: interleukin‐1β inhibits progesterone receptor expression in decidual cells. The Journal Of Pathology 2015, 237: 423-434. PMID: 26175191, DOI: 10.1002/path.4589.Peer-Reviewed Original ResearchConceptsProgesterone receptor expressionPreterm birthDecidual cellsPR expressionIL-1βDC culturesReceptor expressionPR levelsIL-1β suppressionLower PR levelsFunctional progesterone withdrawalCOX-2 expressionRelease of cytokinesIL-1β treatmentDecidual prostaglandin productionP38 MAPK signaling cascadesCervical ripeningProgesterone withdrawalCOX inhibitorsImmunohistochemical stainingChorioamnionitisFetal membrane ruptureNF-kBProstaglandin productionPGF2α productionEnhanced Human Decidual Cell–Expressed FKBP51 May Promote Labor-Related Functional Progesterone Withdrawal
Schatz F, Guzeloglu-Kayisli O, Basar M, Buchwalder LF, Ocak N, Guzel E, Guller S, Semerci N, Kayisli UA, Lockwood CJ. Enhanced Human Decidual Cell–Expressed FKBP51 May Promote Labor-Related Functional Progesterone Withdrawal. American Journal Of Pathology 2015, 185: 2402-2411. PMID: 26207680, DOI: 10.1016/j.ajpath.2015.05.014.Peer-Reviewed Original ResearchConceptsTerm decidual cellsDecidual cellsProgesterone receptorP4 withdrawalInterstitial trophoblastMedroxyprogesterone acetateDC culturesHuman term labourLow progesterone receptorsGlucocorticoid receptor expressionFunctional progesterone withdrawalCultured decidual cellsHuman decidual cellsPlasma progesterone levelsThird trimester trophoblastDC nucleiDecidual sectionsOrganon 2058Plasma P4 levelsTerm laborPR expressionProgesterone withdrawalProgesterone levelsReceptor expressionGR expression