2015
Mechanisms of chorioamnionitis‐associated preterm birth: interleukin‐1β inhibits progesterone receptor expression in decidual cells
Guzeloglu-Kayisli O, Kayisli UA, Semerci N, Basar M, Buchwalder LF, Buhimschi CS, Buhimschi IA, Arcuri F, Larsen K, Huang JS, Schatz F, Lockwood CJ. Mechanisms of chorioamnionitis‐associated preterm birth: interleukin‐1β inhibits progesterone receptor expression in decidual cells. The Journal Of Pathology 2015, 237: 423-434. PMID: 26175191, DOI: 10.1002/path.4589.Peer-Reviewed Original ResearchConceptsProgesterone receptor expressionPreterm birthDecidual cellsPR expressionIL-1βDC culturesReceptor expressionPR levelsIL-1β suppressionLower PR levelsFunctional progesterone withdrawalCOX-2 expressionRelease of cytokinesIL-1β treatmentDecidual prostaglandin productionP38 MAPK signaling cascadesCervical ripeningProgesterone withdrawalCOX inhibitorsImmunohistochemical stainingChorioamnionitisFetal membrane ruptureNF-kBProstaglandin productionPGF2α production
2014
The comparative effects of perindopril and catechin on mesangial matrix and podocytes in the streptozotocin induced diabetic rats
Ertürküner S, Başar M, Tunçdemir M, Seçkin İ. The comparative effects of perindopril and catechin on mesangial matrix and podocytes in the streptozotocin induced diabetic rats. Pharmacological Reports 2014, 66: 279-287. PMID: 24911082, DOI: 10.1016/j.pharep.2013.09.010.Peer-Reviewed Original ResearchConceptsUntreated diabetic groupDiabetic groupMesangial matrixControl groupDiabetic nephropathyDiabetes mellitusEnd-stage kidney failureOxidative stressExperimental diabetic nephropathyHigh blood pressureAdult Wistar AlbinoGlomerular mesangial matrixBlood glucose valuesExcessive reactive oxygen species (ROS) productionReactive oxygen species productionBlood pressureKidney weightDiabetic ratsKidney failureImmunohistochemical stainingOxygen species productionPodocyte damageBody weightEnzyme inhibitorsWistar albino