2012
Coagulases as Determinants of Protective Immune Responses against Staphylococcus aureus
McAdow M, DeDent AC, Emolo C, Cheng AG, Kreiswirth BN, Missiakas DM, Schneewind O. Coagulases as Determinants of Protective Immune Responses against Staphylococcus aureus. Infection And Immunity 2012, 80: 3389-3398. PMID: 22825443, PMCID: PMC3457572, DOI: 10.1128/iai.00562-12.Peer-Reviewed Original Research
2011
Preventing Staphylococcus aureus Sepsis through the Inhibition of Its Agglutination in Blood
McAdow M, Kim HK, DeDent AC, Hendrickx AP, Schneewind O, Missiakas DM. Preventing Staphylococcus aureus Sepsis through the Inhibition of Its Agglutination in Blood. PLOS Pathogens 2011, 7: e1002307. PMID: 22028651, PMCID: PMC3197598, DOI: 10.1371/journal.ppat.1002307.Peer-Reviewed Original ResearchMeSH KeywordsAgglutinationAnimalsAntibodies, NeutralizingAntithrombinsBacterial ProteinsCarrier ProteinsCoagulantsCoagulaseDisease Models, AnimalHeartHost-Pathogen InteractionsHumansImmunization, PassiveLongevityMiceMice, Inbred BALB CMyocardiumProtein BindingSepsisStaphylococcal InfectionsStaphylococcus aureusVon Willebrand FactorConceptsAureus sepsisLethal outcomeDabigatran etexilate treatmentS. aureus sepsisDirect thrombin inhibitorStaphylococcus aureus sepsisStaphylococcus aureus infectionVon Willebrand factorThromboembolic lesionsStaphylococcal sepsisAureus infectionFrequent causeMouse modelSepsisDisease pathogenesisHigh mortalityThrombin inhibitorsBacterial factorsSpecific interventionsHeart tissueWillebrand factorFibrin cableVirulence genesAgglutinationDisease