2024
Neighborhood Food Access in Early Life and Trajectories of Child Body Mass Index and Obesity
Aris I, Wu A, Lin P, Zhang M, Farid H, Hedderson M, Zhu Y, Ferrara A, Chehab R, Barrett E, Carnell S, Camargo C, Chu S, Mirzakhani H, Kelly R, Comstock S, Strakovsky R, O’Connor T, Ganiban J, Dunlop A, Dabelea D, Breton C, Bastain T, Farzan S, Call C, Hartert T, Snyder B, Santarossa S, Cassidy-Bushrow A, O’Shea T, McCormack L, Karagas M, McEvoy C, Alshawabkeh A, Zimmerman E, Wright R, McCann M, Wright R, Coull B, Amutah-Onukagha N, Hacker M, James-Todd T, Oken E, Smith P, Newby L, Adair L, Jacobson L, Catellier D, McGrath M, Douglas C, Duggal P, Knapp E, Kress A, Blackwell C, Mansolf M, Lai J, Ho E, Cella D, Gershon R, Macy M, Das S, Freedman J, Mallal S, McLean J, Shah R, Shilts M, Alshawabkeh A, Cordero J, Meeker J, Trasande L, Camargo C, Hasegawa K, Zhu Z, Sullivan A, Dabelea D, Perng W, Bekelman T, Wilkening G, Magzamen S, Moore B, Starling A, Rinehart D, Koinis Mitchell D, D'Sa V, Deoni S, Mueller H, Duarte C, Monk C, Canino G, Posner J, Murray T, Lugo-Candelas C, Dunlop A, Brennan P, Hockett C, Elliott A, Ferrara A, Croen L, Hedderson M, Ainsworth J, Bacharier L, Bendixsen C, Gern J, Gold D, Hartert T, Jackson D, Johnson C, Joseph C, Kattan M, Khurana Hershey G, Lemanske, Jr. R, Lynch S, Miller R, O’Connor G, Ober C, Ownby D, Rivera-Spoljaric K, Ryan P, Seroogy C, Singh A, Wood R, Zoratti E, Habre R, Farzan S, Gilliland F, Hertz-Picciotto I, Bennett D, Schweitzer J, Schmidt R, LaSalle J, Hipwell A, Keenan K, Karr C, Bush N, LeWinn K, Sathyanarayana S, Zhao Q, Tylavsky F, Carroll K, Loftus C, Leve L, Ganiban J, Neiderhiser J, Weiss S, Litonjua A, McEvoy C, Spindel E, Tepper R, Newschaffer C, Lyall K, Volk H, Landa R, Ozonoff S, Piven J, Hazlett H, Pandey J, Schultz R, Dager S, Botteron K, Messinger D, Stone W, Ames J, O'Connor T, Miller R, Oken E, Hacker M, James-Todd T, O'Shea T, Fry R, Frazier J, Singh R, Rollins C, Montgomery A, Vaidya R, Joseph R, Washburn L, Gogcu S, Bear K, Rollins J, Hooper S, Taylor G, Jackson W, Thompson A, Daniels J, Hernandez M, Lu K, Msall M, Lenski M, Obeid R, Pastyrnak S, Jensen E, Sakai C, Santos H, Kerver J, Paneth N, Barone C, Elliott M, Ruden D, Fussman C, Herbstman J, Margolis A, Schantz S, Geiger S, Aguiar A, Tabb K, Strakovsky R, Woodruff T, Morello-Frosch R, Padula A, Stanford J, Porucznik C, Giardino A, Wright R, Wright R, Collett B, Baumann-Blackmore N, Gangnon R, McKennan C, Wilson J, Altman M, Aschner J, Stroustrup A, Merhar S, Moore P, Pryhuber G, Hudak M, Reynolds Lyndaker A, Lampland A, Rochelson B, Jan S, Blitz M, Katzow M, Brown Z, Chiuzan C, Rafael T, Lewis D, Meirowitz N, Poindexter B, Gebretsadik T, Osmundson S, Straughen J, Eapen A, Cassidy-Bushrow A, Wegienka G, Sitarik A, Woodcroft K, Urquhart A, Levin A, Johnson-Hooper T, Davidson B, Ma T, Barrett E, Blaser M, Dominguez-Bello M, Horton D, Jimenez M, Rosen T, Palomares K, Avalos L, Zhu Y, Hunt K, Newman R, Bloom M, Alkis M, Roberts J, Mumford S, Burris H, DeMauro S, Yee L, Hamvas A, Olidipo A, Haddad A, Eiland L, Spillane N, Suri K, Fisher S, Goldstein J, Mithal L, DeRegnier R, Maitre N, Nguyen R, JaKa M, Sidebottom A, Paidas M, Potter J, Ruby N, Duthely L, Jayakumar A, Young K, Maldonado I, Miller M, Slaughter J, Keim S, Lynch C, Venkatesh K, Whitworth K, Symanski E, Northrup T, Mendez-Figueroa H, Mosquera R, Karagas M, Madan J, MacKenzie D, Lewis J, Rennie B, Leventhal B, Kim Y, Bishop S, Nozadi S, Luo L, Lester B, Marsit C, Everson T, Loncar C, McGowan E, Sheinkopf S, Carter B, Check J, Helderman J, Neal C, Smith L. Neighborhood Food Access in Early Life and Trajectories of Child Body Mass Index and Obesity. JAMA Pediatrics 2024, 178: 1172-1182. PMID: 39283628, PMCID: PMC11406455, DOI: 10.1001/jamapediatrics.2024.3459.Peer-Reviewed Original ResearchConceptsChild body mass indexLow food accessBody mass indexNeighborhood food accessChild obesityObesity riskLow-incomeFood accessAccess neighborhoodsAssociated with higher BMI z-scoreHigher BMI z-scoreBody mass index z-scoreHigher risk of obesityPrevent child obesityHigher obesity riskGeocoded residential addressesIndividual sociodemographic characteristicsBMI z-scoreRisk of obesityZ-scoreImprove food accessLow-income neighborhoodsExposure in early lifeSevere obesityEarly lifeMechanism of Alzheimer type II astrocyte development in hepatic encephalopathy
Tong X, Norenberg M, Paidas M, Shamaladevi N, Salgueiro L, Jaszberenyi M, John B, Hussain H, El Hiba O, Abdeljalil E, Bilal E, Natarajan S, Romaguera R, Papayan S, Carden A, Ramamoorthy R, Elumalai N, Schally A, Nithura J, Patrizio R, Jayakumar A. Mechanism of Alzheimer type II astrocyte development in hepatic encephalopathy. Neurochemistry International 2024, 180: 105866. PMID: 39369794, DOI: 10.1016/j.neuint.2024.105866.Peer-Reviewed Original ResearchType C HEMotor deficitsChronic liver failureHuman post-mortem brain sectionsLiver failureC HEInflammatory factorsOxidative/nitrosative stressPost-mortem brain sectionsIncreased levelsType C hepatic encephalopathyDeficitsMotor disturbancesLevels of inflammatory factorsTreatment in vitroTAA-treated ratsBrain sectionsLevels of GFAPHistopathological findingsIncreased oxidative/nitrosative stressHepatic encephalopathyW-7Pharmacological inhibitionAstrocyte culturesMotorP-438 Association of uterine cavity immune cells at the time of frozen embryo transfer with live birth
Rodriguez S, Ibrahim M, Padula L, Fisher E, Rivas K, Paidas M, Strbo N, Attia G. P-438 Association of uterine cavity immune cells at the time of frozen embryo transfer with live birth. Human Reproduction 2024, 39: deae108.787. DOI: 10.1093/humrep/deae108.787.Peer-Reviewed Original ResearchTiming of frozen embryo transferFrozen embryo transferImprove pregnancy ratesT regulatory cellsLive birthsEmbryo transferImmune cellsPregnancy rateUterine segmentInfluence implantationUltrasound guidanceUterine milieuEndometrial receptivityElective single embryo transferFc receptor-positive cellsUpper uterusTotal immune cellsLower uterine segmentInstitutional review board approvalLive-born infantsSingle embryo transferImmune cell profilesLive birth rateGamma delta TCRImmune cell subsetsPostmenopausal Pregnancy Via Oocyte Donor and Suspected Focal Placenta Accreta: A Case Report
Hajjar R, Cooper S, Elumalai N, Hussain H, Patrizio R, Sinno A, Ahmad A, Marbin S, Ruiz-Cordero R, Paidas M, Jayakumar A. Postmenopausal Pregnancy Via Oocyte Donor and Suspected Focal Placenta Accreta: A Case Report. Cureus 2024, 16: e62332. PMID: 38882221, PMCID: PMC11178238, DOI: 10.7759/cureus.62332.Peer-Reviewed Original ResearchFocal placenta accretaPlacenta accreta spectrumPlacenta accretaPostmenopausal womenSuperimposed pre-eclampsiaAdvanced maternal agePresence of inflammatory cellsChronic kidney injuryHigher prevalence of medical comorbiditiesIn vitro fertilizationPrevalence of medical comorbiditiesCongested blood vesselsAssisted reproductive technologyCesarean deliveryPlacenta previaUterine surgeryPlacental pathologyPre-eclampsiaChronic hypertensionPlacental healthPlacental homeostasisPlacental architectureChorionic villiMaternal ageKidney injurySPIKENET: An Evidence-Based Therapy for Long COVID
Elumalai N, Hussain H, Sampath N, Shamaladevi N, Hajjar R, Druyan B, Rashed A, Ramamoorthy R, Kenyon N, Jayakumar A, Paidas M. SPIKENET: An Evidence-Based Therapy for Long COVID. Viruses 2024, 16: 838. PMID: 38932130, PMCID: PMC11209161, DOI: 10.3390/v16060838.Peer-Reviewed Original ResearchCarcinoembryonic antigen-related cell adhesion molecule 1Murine hepatitis virus-1Post-acute sequelae of COVID-19SARS-CoV-2 variantsSARS-CoV-2Development of severe inflammationCell adhesion molecule 1Long-term complicationsAdhesion molecule 1Multiple organ damagePotential therapeutic benefitMultiple SARS-CoV-2 variantsEvidence-based therapiesSequelae of COVID-19ACE2 receptor-binding domainSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Severe inflammationTissue edemaOrgan damageRespiratory syndrome coronavirus 2Long COVIDMolecule 1Receptor-binding domainSyndrome coronavirus 2Acute and Long COVID Intestinal Changes in an Experimental Model of Coronavirus in Mice
Hussain H, Elumalai N, Sampath N, Shamaladevi N, Hajjar R, Druyan B, Rashed A, Ramamoorthy R, Kenyon N, Jayakumar A, Paidas M. Acute and Long COVID Intestinal Changes in an Experimental Model of Coronavirus in Mice. Viruses 2024, 16: 832. PMID: 38932125, PMCID: PMC11209276, DOI: 10.3390/v16060832.Peer-Reviewed Original ResearchMurine hepatitis virus-1Inflammatory bowel diseaseCeliac diseaseImmune cell infiltrationDevelopment of targeted therapeutic strategiesGoblet cell hyperplasiaHistopathological alterationsRestore tissue homeostasisAmeliorating inflammatory responsesLung complicationsGastrointestinal complicationsMucosal inflammationLymphoid hyperplasiaCell hyperplasiaCardiovascular abnormalitiesMurine modelCell infiltrationInflammatory profileRestore tissue architectureVillous atrophyEpithelial integrityMouse modelPathological featuresTherapeutic strategiesExposure to SARS-CoV-2Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia
Berbrier D, Adler T, Leone C, Paidas M, Stachenfeld N, Usselman C. Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia. AJP Heart And Circulatory Physiology 2024, 327: h140-h154. PMID: 38700469, DOI: 10.1152/ajpheart.00020.2024.Peer-Reviewed Original ResearchMuscle sympathetic nerve activitySystolic blood pressureResponse to acute stimuliIsometric handgrip exercise protocolMental stressHandgrip exercise protocolCardiovascular diseaseExercise-induced increaseEffective prevention strategiesAcute stimuliExercise protocolHistory of preeclampsiaBlood pressureIntegrated muscle sympathetic nerve activityElevated long-term riskElevated cardiovascular riskLong-term riskEnd-expiratory apneaSympathetic nerve activityPrevention strategiesHandgrip exerciseBlood pressure responseRisk factorsExaggerated pressorHealthy pregnancyThe Necessity of Type and Screen Result Prior to Proceeding to Operating Room for Scheduled Cesarean Delivery in a Low Hemorrhage Risk Population [ID 2683392]
Hoffmann E, Druyan B, Fletcher M, Ridore M, Paidas M, Toledo P. The Necessity of Type and Screen Result Prior to Proceeding to Operating Room for Scheduled Cesarean Delivery in a Low Hemorrhage Risk Population [ID 2683392]. Obstetrics And Gynecology 2024, 143: 52s-53s. DOI: 10.1097/01.aog.0001013676.39387.ba.Peer-Reviewed Original ResearchScheduled cesarean deliveryCesarean deliveryBlood transfusionHemorrhage scoreOperating roomIRB-approved retrospective cohort studyTime of blood transfusionTransfused intra-operativelyRetrospective cohort studyChart reviewIntra-operativelyPhysician dissatisfactionCohort studyTransfusionRisk populationPatientsOR delaysBloodScreening resultsScoresMandatory typeDeliveryFinancial ramificationsScreeningHemorrhageAssessment of immune cells in the uterine fluid at the time of the embryo transfer
Strbo N, Rodriguez S, Padula L, Fisher E, Lyons A, Rodriguez C, Rivas K, Ibrahim M, Paidas M, Attia G. Assessment of immune cells in the uterine fluid at the time of the embryo transfer. American Journal Of Reproductive Immunology 2024, 91: e13842. PMID: 38650366, DOI: 10.1111/aji.13842.Peer-Reviewed Original ResearchConceptsGamma delta T cellsFrozen embryo transferLower uterusAssisted reproductive technologyIn vitro fertilizationTransfer catheterT cellsEmbryo transferTime of implantationImmune milieuUpper uterusImmune cellsUltrasound guidanceExpression of CD4+ T cellsAssessment of immune cellsImprove IVF outcomesCD8+ T cellsCD4+ T cellsPopulation of T cellsComposition of immune cellsLower uterine segmentTime of embryo transferExpression of CD3+T regulatory cellsCD3+ cellsAge and Sex in the Development of Hepatic Encephalopathy: Role of Alcohol
Tong X, Hussain H, Shamaladevi N, Norenberg M, Fadel A, Hiba O, Abdeljalil E, El-Mansoury B, Kempuraj D, Natarajan S, Schally A, Jaszberenyi M, Salgueiro L, Paidas M, Jayakumar A. Age and Sex in the Development of Hepatic Encephalopathy: Role of Alcohol. Biology 2024, 13: 228. PMID: 38666840, PMCID: PMC11048384, DOI: 10.3390/biology13040228.Peer-Reviewed Original ResearchFemale ratsMiddle-aged ratsAged male ratsAged female ratsBehavioral deficitsType C HEHepatic encephalopathyBrain edemaTAA-induced HELiver failureAged malesAged femalesMale ratsBehavioral changesAdult ratsChronic HEDevelopment of hepatic encephalopathySustained plasma levelsAcute liver failureMiddle-agedEtOHAcute HEC HEBrainDrug-inducedSpeculum-free portable preterm imaging system
Boonya-Ananta T, Gonzalez M, Ajmal A, Du Le V, DeHoog E, Paidas M, Jayakumar A, Ramella-Roman J. Speculum-free portable preterm imaging system. Journal Of Biomedical Optics 2024, 29: 052918-052918. PMID: 38282917, PMCID: PMC10821769, DOI: 10.1117/1.jbo.29.5.052918.Peer-Reviewed Original ResearchConceptsNon-pregnant volunteersWeeks of gestationMortality rateNon-pregnant cervixCervical imagesPreterm birth riskStandard of careMaternal mortality rateUterine cervixPreterm birthPremature birthWomen's reproductive healthBirth riskCervixQuality of lifeDevelopmental impairmentReproductive healthBirthPatientsInfantsInfant mortality rateReducing infantInsertion sheathImaging probesPatient careDermatologic Changes in Experimental Model of Long COVID
Hussain H, Paidas M, Rajalakshmi R, Fadel A, Ali M, Chen P, Jayakumar A. Dermatologic Changes in Experimental Model of Long COVID. Microorganisms 2024, 12: 272. PMID: 38399677, PMCID: PMC10892887, DOI: 10.3390/microorganisms12020272.Peer-Reviewed Original ResearchMurine hepatitis virus-1Consistent with human studiesAbsence of hair folliclesPost-SARS-CoV-2 infectionHair folliclesAnti-inflammatory responseLong-term health repercussionsPulmonary complicationsFollicle lossDermal layerLiver dysfunctionKidney impairmentCutaneous findingsSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Tissue destructionDermatological changesAcute stageCoronavirus disease-19Pathophysiological changesHuman studiesCollagen depositionSkin alterationsSyndrome coronavirus 2549 FOX signaling mediates PLSCR1 and cytokine-induced inflammation of the lung in long-COVID
Paidas M, Ramamoorthy R, Hussain H, Chen P, Young K, Wu S, Deepa S, Yuan H, Masciarella A, Di Gregorio D, Ravelo N, Jayakumar A. 549 FOX signaling mediates PLSCR1 and cytokine-induced inflammation of the lung in long-COVID. American Journal Of Obstetrics And Gynecology 2024, 230: s298. DOI: 10.1016/j.ajog.2023.11.574.Peer-Reviewed Original Research1100 Major congenital malformation in an experimental mouse model of COVID-19
Paidas M, Hussain H, Ramamoorthy R, Masciarella A, Di Gregorio D, Ravelo N, Chen P, kwal J, Jayakumar A. 1100 Major congenital malformation in an experimental mouse model of COVID-19. American Journal Of Obstetrics And Gynecology 2024, 230: s577-s578. DOI: 10.1016/j.ajog.2023.11.1127.Peer-Reviewed Original Research
2023
Inherited and Acquired Thrombophilias
Abhari P, Paidas M. Inherited and Acquired Thrombophilias. 2023, 114-122. DOI: 10.1002/9781119636540.ch14.Peer-Reviewed Original ResearchThrombophilic conditionsTransient hypercoagulable stateCoagulation factor levelsContext of pregnancyAcquired ThrombophiliaAntifibrinolytic systemsNeonatal outcomesProthrombotic tendencyHypercoagulable stateHormonal changesClinical consequencesThrombotic conditionsFactor levelsPregnancyThrombophiliaMaternalDiagnosisEffect of Diet Patterns in the Prevention of Alzheimer’s Disease
Cosio D, Rodriguez S, Jayakumar A, Paidas M. Effect of Diet Patterns in the Prevention of Alzheimer’s Disease. Nutritional Neurosciences 2023, 197-222. DOI: 10.1007/978-981-99-0677-2_13.Peer-Reviewed Original ResearchWestern pattern dietDiet patternProgression of ADMediterranean dietMediterranean-DASH InterventionAlzheimer's diseaseCase-control studyRandomized controlled trialsPrevention of Alzheimer's diseaseDementia casesNeurodegenerative DelayRates of retentionStop HypertensionPathogenesis of ADRandomized case-control studyAD prevalenceControlled trialsDietary ApproachesDementiaTreatment of ADCognitive measuresDietary interventionEarly stages of disease progressionInterventionPreventionAdvantages and Disadvantages of Nutraceuticals
Rajalakshmi R, Melians M, Pon F, Cosio D, Buvarahamurthy V, Jayakumar A, Paidas M. Advantages and Disadvantages of Nutraceuticals. Nutritional Neurosciences 2023, 245-286. DOI: 10.1007/978-981-99-0677-2_15.Peer-Reviewed Original ResearchEfficacy of nutraceuticalsHeavy metalsLimitations of nutraceuticalsPoor bioavailabilityDrug bioavailabilityBioavailabilityNutraceutical marketLack of experimental evidencePrevent chronic diseasesContaminationPatient health issuesSide effectsHealth professionalsNutrientsNutraceuticalsSide effect profileMetalChronic diseasesRaw materialsHealth issuesToxicityToxic side effectsCompoundsDrug-drug interactionsBlood-brain barrierFat and Alzheimer’s Disease
Rodriguez S, Thiruchelvi R, Justin Thenmozhi A, Cosio D, Shamaladevi N, Hussain H, Sampath N, Paidas M, Jayakumar A. Fat and Alzheimer’s Disease. Nutritional Neurosciences 2023, 67-89. DOI: 10.1007/978-981-99-0677-2_5.Peer-Reviewed Original ResearchAccumulation of beta-amyloidDNA-binding proteinsPlasma membrane cholesterolTransactive response DNA-binding proteinTau protein accumulationBeta-amyloidProtein accumulationBrain microvessel endothelial cellsMembrane cholesterolPathological processesAlzheimer's diseaseDecreased cholesterol levelsPhysiological propertiesIn vivoCellsHyperphosphorylationAssociation of hypercholesterolemiaMicrovessel endothelial cellsAccumulationImpact of hypercholesterolemiaEndothelial cellsDiabetes mellitus IIManagement of hypercholesterolemiaGeneticsEnzymeIdentifying Pregnancies at Higher Risk for HPA-1a Alloimmunization and Fetal/Neonatal Alloimmune Thrombocytopenia (FNAIT): An International, Prospective, Natural History Study
Vander Haar E, Ware C, Allen G, Armstrong R, Black D, Bombara M, Dhanraj D, Lawrence L, Miller R, Nanda S, Paidas M, Patki K, Sitras V, Skupski D, Swarup M, Thorp J, Tiller H, Verweij J, Bussel J. Identifying Pregnancies at Higher Risk for HPA-1a Alloimmunization and Fetal/Neonatal Alloimmune Thrombocytopenia (FNAIT): An International, Prospective, Natural History Study. Blood 2023, 142: 1224. DOI: 10.1182/blood-2023-177657.Peer-Reviewed Original ResearchFetal/Neonatal Alloimmune ThrombocytopeniaHPA-1a alloimmunizationNeonatal alloimmune thrombocytopeniaPregnant womenHuman platelet antigensNatural history studiesFetal deathNeonatal thrombocytopeniaSecond trimesterPlatelet countAlloimmune thrombocytopeniaRisk pregnanciesWeek 10HPA-1a negative womenAdministration of prophylaxisAntenatal intravenous immunoglobulinHPA-1bb womenLifelong neurological impairmentMultiple European centersSevere neonatal thrombocytopeniaHigh-risk womenSingle-arm studyFetal platelet countGestational weeks 10First epidemiological studyA Mouse Model of MHV‐1 Virus Infection for Study of Acute and Long COVID Infection
Masciarella A, Di Gregorio D, Ramamoorthy R, Hussain H, Jayakumar A, Paidas M. A Mouse Model of MHV‐1 Virus Infection for Study of Acute and Long COVID Infection. Current Protocols 2023, 3: e896. PMID: 37867460, PMCID: PMC10606938, DOI: 10.1002/cpz1.896.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Pathological changesMouse modelTransgenic miceLong-term organ dysfunctionSARS-CoV-2 pathophysiologyIrreversible neurological complicationsPotential therapeutic interventionsAvailable human dataBiosafety level 2 laboratoryNon-human primatesBiosafety level 3 laboratoryNeurological complicationsOrgan dysfunctionAcute stageClinical symptomsLong-term effectsSevere casesClinical observationsViral infectionTherapeutic interventionsMHV-1Animal preparationsWeight lossBSL-3 laboratory