2023
A Mouse Model of MHV‐1 Virus Infection for Study of Acute and Long COVID Infection
Masciarella A, Di Gregorio D, Ramamoorthy R, Hussain H, Jayakumar A, Paidas M. A Mouse Model of MHV‐1 Virus Infection for Study of Acute and Long COVID Infection. Current Protocols 2023, 3: e896. PMID: 37867460, PMCID: PMC10606938, DOI: 10.1002/cpz1.896.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCOVID-19Disease Models, AnimalHumansMiceMice, Inbred StrainsMice, TransgenicMurine hepatitis virusPost-Acute COVID-19 SyndromeSARS-CoV-2ConceptsSARS-CoV-2Pathological changesMouse modelTransgenic miceLong-term organ dysfunctionSARS-CoV-2 pathophysiologyIrreversible neurological complicationsPotential therapeutic interventionsAvailable human dataBiosafety level 2 laboratoryNon-human primatesBiosafety level 3 laboratoryNeurological complicationsOrgan dysfunctionAcute stageClinical symptomsLong-term effectsSevere casesClinical observationsViral infectionTherapeutic interventionsMHV-1Animal preparationsWeight lossBSL-3 laboratory
2011
Preimplantation Factor (PIF*) reverses neuroinflammation while promoting neural repair in EAE model
Weiss L, Or R, Jones RC, Amunugama R, JeBailey L, Ramu S, Bernstein SA, Yekhtin Z, Almogi-Hazan O, Shainer R, Reibstein I, Vortmeyer AO, Paidas MJ, Zeira M, Slavin S, Barnea ER. Preimplantation Factor (PIF*) reverses neuroinflammation while promoting neural repair in EAE model. Journal Of The Neurological Sciences 2011, 312: 146-157. PMID: 21996270, DOI: 10.1016/j.jns.2011.07.050.Peer-Reviewed Original ResearchConceptsInflammatory cellsPro-inflammatory cytokines/chemokinesPreserves islet functionCytokines/chemokinesSignificant neuroprotective effectsSpinal cord histologyPreImplantation FactorSplenocyte cytokinesEAE modelChronic modelNeuroprotective effectsMaternal immunityClinical indicesChronic paralysisSpinal cordJuvenile diabetesMulti-targeted actionSynaptic transmissionCord histologyIslet functionIL6 secretionCoagulation factorsNeural repairClinical testingDay 82