2024
Acute and Long COVID Intestinal Changes in an Experimental Model of Coronavirus in Mice
Hussain H, Elumalai N, Sampath N, Shamaladevi N, Hajjar R, Druyan B, Rashed A, Ramamoorthy R, Kenyon N, Jayakumar A, Paidas M. Acute and Long COVID Intestinal Changes in an Experimental Model of Coronavirus in Mice. Viruses 2024, 16: 832. PMID: 38932125, PMCID: PMC11209276, DOI: 10.3390/v16060832.Peer-Reviewed Original ResearchMurine hepatitis virus-1Inflammatory bowel diseaseCeliac diseaseImmune cell infiltrationDevelopment of targeted therapeutic strategiesGoblet cell hyperplasiaHistopathological alterationsRestore tissue homeostasisAmeliorating inflammatory responsesLung complicationsGastrointestinal complicationsMucosal inflammationLymphoid hyperplasiaCell hyperplasiaCardiovascular abnormalitiesMurine modelCell infiltrationInflammatory profileRestore tissue architectureVillous atrophyEpithelial integrityMouse modelPathological featuresTherapeutic strategiesExposure to SARS-CoV-2
2023
A Mouse Model of MHV‐1 Virus Infection for Study of Acute and Long COVID Infection
Masciarella A, Di Gregorio D, Ramamoorthy R, Hussain H, Jayakumar A, Paidas M. A Mouse Model of MHV‐1 Virus Infection for Study of Acute and Long COVID Infection. Current Protocols 2023, 3: e896. PMID: 37867460, PMCID: PMC10606938, DOI: 10.1002/cpz1.896.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Pathological changesMouse modelTransgenic miceLong-term organ dysfunctionSARS-CoV-2 pathophysiologyIrreversible neurological complicationsPotential therapeutic interventionsAvailable human dataBiosafety level 2 laboratoryNon-human primatesBiosafety level 3 laboratoryNeurological complicationsOrgan dysfunctionAcute stageClinical symptomsLong-term effectsSevere casesClinical observationsViral infectionTherapeutic interventionsMHV-1Animal preparationsWeight lossBSL-3 laboratory