Preimplantation Factor (PIF*) reverses neuroinflammation while promoting neural repair in EAE model
Weiss L, Or R, Jones RC, Amunugama R, JeBailey L, Ramu S, Bernstein SA, Yekhtin Z, Almogi-Hazan O, Shainer R, Reibstein I, Vortmeyer AO, Paidas MJ, Zeira M, Slavin S, Barnea ER. Preimplantation Factor (PIF*) reverses neuroinflammation while promoting neural repair in EAE model. Journal Of The Neurological Sciences 2011, 312: 146-157. PMID: 21996270, DOI: 10.1016/j.jns.2011.07.050.Peer-Reviewed Original ResearchConceptsInflammatory cellsPro-inflammatory cytokines/chemokinesPreserves islet functionCytokines/chemokinesSignificant neuroprotective effectsSpinal cord histologyPreImplantation FactorSplenocyte cytokinesEAE modelChronic modelNeuroprotective effectsMaternal immunityClinical indicesChronic paralysisSpinal cordJuvenile diabetesMulti-targeted actionSynaptic transmissionCord histologyIslet functionIL6 secretionCoagulation factorsNeural repairClinical testingDay 82