Mechanism of Alzheimer type II astrocyte development in hepatic encephalopathy
Tong X, Norenberg M, Paidas M, Shamaladevi N, Salgueiro L, Jaszberenyi M, John B, Hussain H, El Hiba O, Abdeljalil E, Bilal E, Natarajan S, Romaguera R, Papayan S, Carden A, Ramamoorthy R, Elumalai N, Schally A, Nithura J, Patrizio R, Jayakumar A. Mechanism of Alzheimer type II astrocyte development in hepatic encephalopathy. Neurochemistry International 2024, 180: 105866. PMID: 39369794, DOI: 10.1016/j.neuint.2024.105866.Peer-Reviewed Original ResearchType C HEMotor deficitsChronic liver failureHuman post-mortem brain sectionsLiver failureC HEInflammatory factorsOxidative/nitrosative stressPost-mortem brain sectionsIncreased levelsType C hepatic encephalopathyDeficitsMotor disturbancesLevels of inflammatory factorsTreatment in vitroTAA-treated ratsBrain sectionsLevels of GFAPHistopathological findingsIncreased oxidative/nitrosative stressHepatic encephalopathyW-7Pharmacological inhibitionAstrocyte culturesMotor