2020
Treatment and outcome of 370 cases with spontaneous or post‐laser twin anemia–polycythemia sequence managed in 17 fetal therapy centers
Tollenaar L, Slaghekke F, Lewi L, Ville Y, Lanna M, Weingertner A, Ryan G, Arévalo S, Khalil A, Brock C, Klaritsch P, Hecher K, Gardener G, Bevilacqua E, Kostyukov K, Bahtiyar M, Kilby M, Tiblad E, Oepkes D, Lopriore E, Middeldorp J, Haak M, Klumper F, Akkermans J, Delagrange H, Pandya V, Faiola S, Favre R, Hobson S, Rodo C, Thilaganathan B, Papanna R, Greimel P, de Sousa M, Carlin A, Gladkova K, Copel J. Treatment and outcome of 370 cases with spontaneous or post‐laser twin anemia–polycythemia sequence managed in 17 fetal therapy centers. Ultrasound In Obstetrics And Gynecology 2020, 56: 378-387. PMID: 32291846, PMCID: PMC7497010, DOI: 10.1002/uog.22042.Peer-Reviewed Original ResearchConceptsTwin anemia-polycythemia sequenceFetal therapy centersMonochorionic twin pregnanciesPost-laser twin anemia-polycythemia sequenceExpectant management groupSevere neonatal morbidityIntrauterine transfusionExpectant managementPerinatal mortalitySelective feticideTwin pregnanciesLaser surgeryNeonatal morbidityDelivery groupIUT groupDiagnosis of TAPSMiddle cerebral artery peak systolic velocityFetal middle cerebral artery peak systolic velocityBirth intervalLaser surgery groupProlongation of pregnancyTherapy CenterPeak systolic velocityLarge international cohortMedian diagnosis
2017
Minimally invasive abdominal cerclage compared to laparotomy: a comparison of surgical and obstetric outcomes
Kim S, Hill A, Menderes G, Cross S, Azodi M, Bahtiyar MO. Minimally invasive abdominal cerclage compared to laparotomy: a comparison of surgical and obstetric outcomes. Journal Of Robotic Surgery 2017, 12: 295-301. PMID: 28721634, DOI: 10.1007/s11701-017-0726-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultCerclage, CervicalFemaleHumansLaparoscopyLaparotomyPregnancyPregnancy OutcomeRetrospective StudiesRobotic Surgical ProceduresConceptsAbdominal cerclage placementAbdominal cerclageObstetric outcomesCerclage placementInvasive groupLive birthsYale-New Haven HospitalSubsequent obstetric outcomesRetrospective cohort studyAverage operative timeHigh-risk pregnanciesCohort of womenElectronic medical chartsRobotic-assisted laparoscopyInvasive gynecologic surgeryNew Haven HospitalElectronic medical recordsObstetric informationHospital stayCohort studyReferral centerBlood lossMedical chartsOperative timeGynecologic surgeryMaternal Anxiety Related to Prenatal Diagnoses of Fetal Anomalies That Require Surgery
Wilpers AB, Kennedy HP, Wall D, Funk M, Bahtiyar MO. Maternal Anxiety Related to Prenatal Diagnoses of Fetal Anomalies That Require Surgery. Journal Of Obstetric Gynecologic & Neonatal Nursing 2017, 46: 456-464. PMID: 28390224, DOI: 10.1016/j.jogn.2017.02.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxiety DisordersCase-Control StudiesCongenital AbnormalitiesFemaleFetusHumansMaternal AgeMothersNew EnglandPilot ProjectsPregnancyPregnancy OutcomePregnancy Trimester, SecondPregnancy Trimester, ThirdPregnancy, High-RiskPrenatal DiagnosisProspective StudiesReference ValuesRisk AssessmentUltrasonography, PrenatalConceptsNurse care coordinatorsFetal anomaliesMaternal ageMaternal anxietyAnxiety scoresComparison pilot studyOlder maternal ageEarly third trimesterHealth history dataU.S. academic medical centersFetal care centersAcademic medical centerMean state anxiety scoreSpielberger State-Trait Anxiety InventoryMental health issuesState-Trait Anxiety InventoryEmotional supportThird trimesterCare coordinatorsMedical recordsRisk factorsCare centerMedical CenterState anxiety scoresPregnancy
2016
Limiting the Exposure of Select Fetuses to Intrauterine Infection/Inflammation Improves Short-Term Neonatal Outcomes in Preterm Premature Rupture of Membranes
Archabald KL, Buhimschi IA, Bahtiyar MO, Dulay AT, Abdel-Razeq SS, Pettker CM, Lipkind HS, Hardy JT, McCarthy ME, Zhao G, Bhandari V, Buhimschi CS. Limiting the Exposure of Select Fetuses to Intrauterine Infection/Inflammation Improves Short-Term Neonatal Outcomes in Preterm Premature Rupture of Membranes. Fetal Diagnosis And Therapy 2016, 42: 99-110. PMID: 27794570, DOI: 10.1159/000450997.Peer-Reviewed Original ResearchConceptsEarly-onset neonatal sepsisNeonatal outcomesPremature ruptureEarly deliveryIntrauterine infection/inflammationSetting of PPROMAdverse neonatal outcomesAmniotic fluid infectionPreterm premature ruptureShort-term outcomesInfection/inflammationIntra-amniotic infectionTerm neonatal outcomesSelect fetusesAntenatal exposureExpectant managementSingleton newbornsHospital dischargeNeonatal sepsisHaptoglobin-related proteinNewborn's riskFluid infectionGestational ageAdverse outcomesSelect subgroup
2015
Screening for Congenital Heart Disease During Anatomical Survey Ultrasonography
Bahtiyar MO, Copel JA. Screening for Congenital Heart Disease During Anatomical Survey Ultrasonography. Obstetrics And Gynecology Clinics Of North America 2015, 42: 209-223. PMID: 26002162, DOI: 10.1016/j.ogc.2015.01.001.Peer-Reviewed Original ResearchConceptsCongenital heart diseasePrevalence of CHDFetal heart examinationCommon congenital abnormalityPrenatal ultrasound examinationNeonatal outcomesHeart diseaseUltrasound examinationHeart examinationHigh prevalenceLive birthsCongenital abnormalitiesPrevalenceAbnormalitiesDetection rateRegular feedbackTraining programExaminationThe North American Fetal Therapy Network Consensus Statement
Emery SP, Bahtiyar MO, Dashe JS, Wilkins-Haug LE, Johnson A, Paek BW, Moon-Grady AJ, Skupski DW, O'Brien BM, Harman CR, Simpson LL. The North American Fetal Therapy Network Consensus Statement. Obstetrics And Gynecology 2015, 125: 1236-1243. PMID: 25932853, DOI: 10.1097/aog.0000000000000723.Peer-Reviewed Original ResearchConceptsMonochorionic gestationsNorth American Fetal Therapy NetworkUnequal placental sharingDetection of complicationsUnique disease processDichorionic gestationsUltrasonographic surveillanceEarly referralPlacental sharingPermanent disabilityConsensus statementPrenatal managementBetter outcomesDisease processClinical practiceGestationSingle placentaTherapy NetworkEarly detectionComplicationsVascular connectionsDeathSurveillanceReferralAngioarchitecture
2014
Doppler abnormalities in monochorionic diamniotic twin pregnancies with discordant growth
Zuckerwise L, Nayeri U, Abdel-Razeq S, Copel J, Bahtiyar M. Doppler abnormalities in monochorionic diamniotic twin pregnancies with discordant growth. Journal Of Perinatology 2014, 35: 387-389. PMID: 25521562, DOI: 10.1038/jp.2014.223.Peer-Reviewed Original ResearchConceptsDoppler flow velocity waveformsFlow velocity waveformsDiscordant growthVelocity waveformsTwin gestationsSmall fetusesAbnormal umbilical artery Doppler flow velocity waveformsUmbilical artery Doppler flow velocity waveformsMonochorionic diamniotic twin gestationsMonochorionic diamniotic twin pregnanciesNeonatal intensive care unitDiamniotic twin gestationsMCDA twin pairsDiamniotic twin pregnanciesEnd-diastolic flowLow Apgar scoreBirth weight discordanceDiscordant fetal growthIntensive care unitTwin transfusion syndromeDoppler velocity waveformsT-testElectronic medical recordsTwin pairsStudent's t-test
2011
Ultrasonographic Evaluation of Myometrial Thickness and Prediction of a Successful External Cephalic Version
Buhimschi CS, Buhimschi IA, Wehrum MJ, Molaskey-Jones S, Sfakianaki AK, Pettker CM, Thung S, Campbell KH, Dulay AT, Funai EF, Bahtiyar MO. Ultrasonographic Evaluation of Myometrial Thickness and Prediction of a Successful External Cephalic Version. Obstetrics And Gynecology 2011, 118: 913-920. PMID: 21934456, DOI: 10.1097/aog.0b013e31822e63fe.Peer-Reviewed Original ResearchConceptsAmniotic fluid indexExternal cephalic versionFundal myometrial thicknessSuccessful external cephalic versionMyometrial thicknessCephalic versionFluid indexHigher amniotic fluid indexAbdominal ultrasonographic scansFetal spine positionConsecutive pregnant womenAbsolute risk reductionBody mass indexExternal cephalic version successStrong independent predictorAbdominal wall thicknessMultivariate regression analysisPlacental thicknessBreech presentationIndependent predictorsFetal weightMass indexPregnant womenUltrasonographic evaluationBirth weight
2010
Is the Rate of Congenital Heart Defects Detected by Fetal Echocardiography Among Pregnancies Conceived by In Vitro Fertilization Really Increased?
Bahtiyar MO, Campbell K, Dulay AT, Kontic-Vucinic O, Weeks BP, Friedman AH, Copel JA. Is the Rate of Congenital Heart Defects Detected by Fetal Echocardiography Among Pregnancies Conceived by In Vitro Fertilization Really Increased? Journal Of Ultrasound In Medicine 2010, 29: 917-922. PMID: 20498466, DOI: 10.7863/jum.2010.29.6.917.Peer-Reviewed Original ResearchConceptsIVF pregnanciesFrequency of CHDsFetal echocardiographyCHD riskGeneral populationCongenital heartContemporary general populationIVF twin pregnanciesHigher-order pregnanciesIntracytoplasmic sperm injectionFertilization pregnanciesStudy patientsTwin gestationsTwin pregnanciesPrenatal prevalencePopulation dataStudy populationHigh riskSperm injectionPregnancyVitro FertilizationEchocardiographyReferral programCHDPatients
2008
Acute Chest Syndrome during Pregnancy as Initial Presentation of Sickle Cell Disease: A Case Report
Campbell K, Ali U, Bahtiyar M. Acute Chest Syndrome during Pregnancy as Initial Presentation of Sickle Cell Disease: A Case Report. American Journal Of Perinatology 2008, 25: 547-549. PMID: 18756432, DOI: 10.1055/s-0028-1085628.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnemia, Sickle CellCesarean SectionChest PainDiagnosis, DifferentialErythrocyte TransfusionFemaleHumansPlasmapheresisPostnatal CarePregnancyPregnancy Complications, HematologicPregnancy OutcomePregnancy Trimester, ThirdPrenatal CareRespiratory InsufficiencyRisk AssessmentSeverity of Illness IndexSyndromeYoung AdultPrenatal Course of Isolated Muscular Ventricular Septal Defects Diagnosed Only by Color Doppler Sonography
Bahtiyar MO, Dulay AT, Weeks BP, Friedman AH, Copel JA. Prenatal Course of Isolated Muscular Ventricular Septal Defects Diagnosed Only by Color Doppler Sonography. Journal Of Ultrasound In Medicine 2008, 27: 715-720. PMID: 18424646, DOI: 10.7863/jum.2008.27.5.715.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesDown SyndromeEchocardiographyFemaleFetal DevelopmentFetal DiseasesFetal HeartFollow-Up StudiesGestational AgeHeart Septal Defects, VentricularHumansInfant, NewbornNuchal Translucency MeasurementPregnancyPregnancy OutcomeProspective StudiesRisk AssessmentTripletsTwinsUltrasonography, Doppler, ColorUltrasonography, PrenatalConceptsVentricular septal defectColor Doppler examinationMuscular VSDDoppler examinationSeptal defectStudy groupIsolated muscular ventricular septal defectTrisomy 21Isolated ventricular septal defectMuscular ventricular septal defectsHigh-resolution ultrasound equipmentCommon congenital heart defectSmall muscular VSDMean gestational ageFetal echocardiographic examinationColor Doppler sonographyCongenital heart defectsPrenatal resolutionTriplet gestationsEchocardiographic examinationGestational ageCounseling patientsPerinatal courseTwin gestationsFirst trimesterUsing Proteomic Analysis of the Human Amniotic Fluid to Identify Histologic Chorioamnionitis
Buhimschi IA, Zambrano E, Pettker CM, Bahtiyar MO, Paidas M, Rosenberg VA, Thung S, Salafia CM, Buhimschi CS. Using Proteomic Analysis of the Human Amniotic Fluid to Identify Histologic Chorioamnionitis. Obstetrics And Gynecology 2008, 111: 403-412. PMID: 18238979, DOI: 10.1097/aog.0b013e31816102aa.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmniocentesisAmniotic FluidBiomarkersBlack or African AmericanChorioamnionitisFemaleHumansInflammationPregnancyPregnancy Complications, InfectiousPregnancy OutcomePrevalenceProteomeProteomicsReproducibility of ResultsSensitivity and SpecificitySeverity of Illness IndexSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationWhite PeopleConceptsHistologic chorioamnionitisAmniotic fluidIntra-amniotic inflammationGrade of inflammationAbsence of biomarkersHuman amniotic fluidSurface-enhanced laser desorption ionization timeAfrican American womenPreterm laborSingleton pregnanciesDelivery intervalPlacental pathologyGestational agePremature ruptureSevere inflammationEarly recognitionChorioamnionitisChorionic plateInflammationTherapeutic interventionsProteomic biomarkersCalgranulin CBiomarkersProteomic analysisScoresMultidimensional System Biology: Genetic Markers and Proteomic Biomarkers of Adverse Pregnancy Outcome in Preterm Birth
Buhimschi C, Rosenberg V, Dulay A, Thung S, Sfakianaki A, Bahtiyar M, Buhimschi I. Multidimensional System Biology: Genetic Markers and Proteomic Biomarkers of Adverse Pregnancy Outcome in Preterm Birth. American Journal Of Perinatology 2008, 25: 175-187. PMID: 18425720, DOI: 10.1055/s-2008-1061497.Peer-Reviewed Original ResearchConceptsPreterm birthSignificant public health problemMost preterm birthsAdverse pregnancy outcomesWeeks of gestationPublic health problemVariety of interventionsNeonatal outcomesPregnancy outcomesDecidual hemorrhagePremature infantsPremature birthLikely multifactorialPathophysiological pathwaysHealth problemsPathophysiological conditionsProteomic biomarkersOxidative stressBirthExcessive stretchingOutcomesHemorrhageGestationInfantsEtiology
2007
Proteomic Profiling of the Amniotic Fluid to Detect Inflammation, Infection, and Neonatal Sepsis
Buhimschi CS, Bhandari V, Hamar BD, Bahtiyar MO, Zhao G, Sfakianaki AK, Pettker CM, Magloire L, Funai E, Norwitz ER, Paidas M, Copel JA, Weiner CP, Lockwood CJ, Buhimschi IA. Proteomic Profiling of the Amniotic Fluid to Detect Inflammation, Infection, and Neonatal Sepsis. PLOS Medicine 2007, 4: e18. PMID: 17227133, PMCID: PMC1769412, DOI: 10.1371/journal.pmed.0040018.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmniocentesisAmniotic FluidBiomarkersFemaleHumansInflammationMiddle AgedPregnancyPregnancy Complications, InfectiousPregnancy OutcomeProteomeProteomicsReproducibility of ResultsSensitivity and SpecificitySepsisSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationConceptsEarly-onset neonatal sepsisAmniotic fluid inflammationIntra-amniotic infectionMR scoreNeonatal sepsisAmniotic fluidHistological chorioamnionitisDelivery intervalNewborn Special Care UnitGram stainEarly-onset sepsisIntra-amniotic inflammationDegree of inflammationSpecial care unitsIntrauterine inflammationPlacental inflammationShorter amniocentesisPreterm deliveryPreterm laborSingleton pregnanciesConsecutive womenPreterm birthCare unitGestational agePremature rupture