2024
Chapter 39 Role in reproductive biology and dysfunction in women
Pal L, Taylor H. Chapter 39 Role in reproductive biology and dysfunction in women. 2024, 873-888. DOI: 10.1016/b978-0-323-91386-7.00036-2.Peer-Reviewed Original ResearchVitamin DMaternal vitamin D statusVitamin D inadequacyVitamin D deficiencyVitamin D statusActive hormonal formReproductive physiologyBeneficial roleVitamin D signalingSpectrum of disordersFemale reproductive functionHuman reproductive physiologyD deficiencyD statusDihydroxyvitamin DFemale reproductive physiologyInsulin resistanceCardiovascular diseaseHormonal formMetabolic milieuD signalingReproductive functionPleotropic effectsPathological processesLimited data
2023
Cardiometabolic outcomes in Kronos Early Estrogen Prevention Study continuation: 14-year follow-up of a hormone therapy trial
Kantarci K, Tosakulwong N, Lesnick T, Kara F, Kendall-Thomas J, Kapoor E, Fields J, James T, Lobo R, Manson J, Pal L, Hammers D, Malek-Ahmadi M, Cedars M, Naftolin F, Santoro N, Miller V, Harman S, Dowling N, Gleason C. Cardiometabolic outcomes in Kronos Early Estrogen Prevention Study continuation: 14-year follow-up of a hormone therapy trial. Menopause The Journal Of The North American Menopause Society 2023, 31: 10-17. PMID: 37989141, PMCID: PMC10756493, DOI: 10.1097/gme.0000000000002278.Peer-Reviewed Original ResearchConceptsKronos Early Estrogen Prevention StudyOral conjugated equine estrogenConjugated equine estrogensBetter cardiovascular healthHormone therapyEquine estrogensInsulin resistanceMenopausal womenCardiovascular healthClinical trialsHormone therapy trialsPerson clinic visitsDiastolic blood pressureHomeostasis model assessmentSelf-reported diabetesYears of onsetMultisite clinical trialLevels of glucoseMicronized progesteroneDiabetes medicationsStudy of participantsCardiometabolic effectsCardiometabolic outcomesClinic visitsBlood pressure
2022
Emerging Concepts: Role of Vitamin D Deficiency in the Pathogenesis of PCOS
Simpson S, Pal L, Seifer D. Emerging Concepts: Role of Vitamin D Deficiency in the Pathogenesis of PCOS. 2022, 489-509. DOI: 10.1007/978-3-030-92589-5_24.Peer-Reviewed Original ResearchPolycystic ovary syndromeVitamin D deficiencyD deficiencyVitamin DDiabetes mellitusCardiovascular diseaseInsulin resistanceContext of PCOSPathogenesis of PCOSType 2 diabetes mellitusParacrine/autocrine roleSpectrum of morbidityMultiple clinical studiesPoor reproductive outcomesAbnormal reproductive functionFeatures of depressionNonhuman primate studiesFemale reproductive tractImpaired folliculogenesisOvary syndromeEndometrial cancerCommon endocrinopathySkeletal healthClinical associationsLifetime risk
2015
Management options and fertility‐preserving therapy for premenopausal endometrial hyperplasia and early‐stage endometrial cancer
Gressel GM, Parkash V, Pal L. Management options and fertility‐preserving therapy for premenopausal endometrial hyperplasia and early‐stage endometrial cancer. International Journal Of Gynecology & Obstetrics 2015, 131: 234-239. PMID: 26384790, DOI: 10.1016/j.ijgo.2015.06.031.Peer-Reviewed Original ResearchConceptsEarly-stage endometrial cancerEndometrial cancerEndometrial hyperplasiaFertility preservationFuture fertilityRisk factorsComplex atypical endometrial hyperplasiaEndometrial hyperplasia/cancerType 2 diabetes mellitusFertility-preserving therapyAtypical endometrial hyperplasiaPolycystic ovarian syndromeChronic anovulationLifestyle modificationPremenopausal womenConservative managementOvarian syndromeDefinitive managementDiabetes mellitusEndometrial pathologyGlycemic controlMetabolic syndromeDATA COLLECTIONCochrane DatabaseInsulin resistance
2014
Polycystic Ovary Syndrome
Pal L, Keefe K. Polycystic Ovary Syndrome. DeckerMed Medicine 2014 DOI: 10.2310/im.1251.ChaptersPolycystic ovary syndromeOvary syndromeManagement of PCOSTreatment of PCOSNational Cholesterol Education Program criteriaFerriman-Gallwey scoring systemType 2 diabetes mellitusCombination of hyperandrogenismObstructive sleep apneaPolycystic ovarian morphologyBody mass indexAdditional sequelaeAnovulatory infertilityPCOS patientsEndometrial hyperplasiaMenstrual disturbancesDiabetes mellitusEndometrial cancerMetabolic syndromeMultifollicular ovariesNonobese womenMass indexSleep apneaEndocrine disordersInsulin resistance
2013
Emerging Concepts: Role of Vitamin D Deficiency in the Pathogenesis of PCOS
Lathief S, Pal L. Emerging Concepts: Role of Vitamin D Deficiency in the Pathogenesis of PCOS. 2013, 317-331. DOI: 10.1007/978-1-4614-8394-6_19.Peer-Reviewed Original ResearchPolycystic ovary syndromeVitamin D deficiencyD deficiencyInsulin resistanceVitamin DDiabetes mellitusCardiovascular diseasePathogenesis of PCOSPathophysiology of PCOSType 2 diabetes mellitusSpectrum of morbidityPoor reproductive outcomesFeatures of depressionImpaired folliculogenesisOvary syndromeEndometrial cancerCommon endocrinopathyEndocrine featuresSkeletal healthAutoimmune diseasesLifetime riskReproductive agePathophysiologic roleMetabolic milieuMood disorders
2011
Chapter 39 Vitamin D Relevance in Reproductive Biology and Pathophysiological Implications in Reproductive Dysfunction
Pal L, Taylor H. Chapter 39 Vitamin D Relevance in Reproductive Biology and Pathophysiological Implications in Reproductive Dysfunction. 2011, 695-705. DOI: 10.1016/b978-0-12-381978-9.10039-3.BooksVitamin D deficiencyVitamin DD deficiencyInsulin resistancePrevention of endometriosisVitamin D inadequacyAutoimmune disordersPathophysiological mechanismsCardiovascular diseaseReproductive dysfunctionReproductive compromiseDisease processPathophysiological implicationsExperimental modelRepletion strategiesKey moleculesFemale fertilityReproductive physiologyAccessible optionDeficiencyCurrent understandingEndometriosisObesityPregnancyDysfunction