Letrozole versus Clomiphene for Infertility in the Polycystic Ovary Syndrome
Legro RS, Brzyski RG, Diamond MP, Coutifaris C, Schlaff WD, Casson P, Christman GM, Huang H, Yan Q, Alvero R, Haisenleder DJ, Barnhart KT, Bates GW, Usadi R, Lucidi S, Baker V, Trussell JC, Krawetz SA, Snyder P, Ohl D, Santoro N, Eisenberg E, Zhang H. Letrozole versus Clomiphene for Infertility in the Polycystic Ovary Syndrome. New England Journal Of Medicine 2014, 371: 119-129. PMID: 25006718, PMCID: PMC4175743, DOI: 10.1056/nejmoa1313517.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeOvary syndromeCongenital anomaliesLive birthsHigh incidenceOvulation rateSignificant between-group differencesCumulative ovulation rateNormal uterine cavityOverall congenital anomaliesBetter pregnancy outcomesPatent fallopian tubesCumulative live birthMajor congenital anomaliesBetween-group differencesYears of ageClomiphene groupLetrozole groupRotterdam criteriaAdverse eventsHot flushesPregnancy outcomesInfertile womenMulticenter trialPrimary outcomeA novel staging model to classify oesophageal squamous cell carcinoma patients in China
Tan H, Zhang H, Xie J, Chen B, Wen C, Guo X, Zhao Q, Wu Z, Shen J, Wu J, Xu X, Li E, Xu L, Wang X. A novel staging model to classify oesophageal squamous cell carcinoma patients in China. British Journal Of Cancer 2014, 110: 2109-2115. PMID: 24569468, PMCID: PMC3992487, DOI: 10.1038/bjc.2014.101.Peer-Reviewed Original ResearchConceptsESCC patientsClinical variablesStaging systemOesophageal squamous cell carcinoma patientsSurvival analysisSquamous cell carcinoma patientsOesophageal squamous cell carcinomaKaplan-Meier survival analysisCell carcinoma patientsPotential prognostic factorsTNM staging systemSquamous cell carcinomaMetastasis (TNM) staging systemOesophageal carcinomaPrognostic factorsCarcinoma patientsCell carcinomaSame hospitalESCC prognosisPredominant subtypeRisk scoreIndependent cohortPatientsSurvival rateStaging model