2008
Modelling gene regulation networks via multivariate adaptive splines.
Chen X, Zhang H. Modelling gene regulation networks via multivariate adaptive splines. Cancer Genomics & Proteomics 2008, 5: 55-62. PMID: 18359980, PMCID: PMC3159687.Peer-Reviewed Original ResearchConceptsRegulatory networksRegulation networkMultivariate adaptive splinesTranscriptional regulation networkTranscriptional regulatory networksGene regulation networksDozens of genomesTranscriptome reprogrammingGene expression time series dataRegulatory motifsHuman genomeTranscription factorsPutative motifsRegulatory functionsRegulatory roleEukaryotesMotifGenomePhysiological conditionsReprogrammingYeastAdaptive splinesIdentification
1997
Strategies to Identify Genes for Complex Diseases
Zhang H, Zhao H, Merikangas K. Strategies to Identify Genes for Complex Diseases. Annals Of Medicine 1997, 29: 493-498. PMID: 9562515, DOI: 10.3109/07853899709007473.Peer-Reviewed Original ResearchConceptsComplex diseasesNumerous human diseasesDisease-susceptible genesComplex human disordersHuman genomeGenetic basisHuman disordersHuman diseasesMolecular biologyGenesGenetic epidemiological studiesGenetic factorsComplex patternsDisease pathophysiologyGenomeBiologyTraitsInheritanceMultiple sclerosisBreast cancerEpidemiological studies