2022
Insulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity
Anam AK, Cooke KM, Dratver MB, O'Bryan JV, Perley LE, Guller SM, Hwang JJ, Taylor HS, Goedeke L, Kliman HJ, Vatner DF, Flannery CA. Insulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity. Molecular Metabolism 2022, 64: 101574. PMID: 35970449, PMCID: PMC9440306, DOI: 10.1016/j.molmet.2022.101574.Peer-Reviewed Original ResearchConceptsDe novo lipogenesisFetal adiposityFatty acid uptakeMaternal obesityObese womenNormal weightExcess adiposityVillous explantsInsulin receptorNewborns of mothersNormal-weight womenAcid uptakePlacental villous explantsTranscription factor SREBP-1Insulin-like growth factor 2Effect of insulinFatty acid oxidationPlacental triglyceridesPlacental responsesElevated triglyceridesMaternal hyperglycemiaWeight womenGrowth factor 2Diabetes riskPlacental metabolism
2018
Type I interferons instigate fetal demise after Zika virus infection
Yockey LJ, Jurado KA, Arora N, Millet A, Rakib T, Milano KM, Hastings AK, Fikrig E, Kong Y, Horvath TL, Weatherbee S, Kliman HJ, Coyne CB, Iwasaki A. Type I interferons instigate fetal demise after Zika virus infection. Science Immunology 2018, 3 PMID: 29305462, PMCID: PMC6049088, DOI: 10.1126/sciimmunol.aao1680.Peer-Reviewed Original ResearchConceptsZika virus infectionZIKV infectionI IFNsI interferonType I interferonGrowth restrictionFetal demiseVirus infectionSevere fetal growth restrictionType I IFNsChorionic villous explantsAdverse fetal outcomesCongenital viral infectionFetal growth restrictionMaternal-fetal barrierType IFunctional type IPlacental damageFetal outcomesPregnancy complicationsEarly pregnancyFetal resorptionZIKV diseasePregnant damsSpontaneous abortionPathway of Maternal Serotonin to the Human Embryo and Fetus
Kliman HJ, Quaratella SB, Setaro AC, Siegman EC, Subha ZT, Tal R, Milano KM, Steck TL. Pathway of Maternal Serotonin to the Human Embryo and Fetus. Endocrinology 2018, 159: 1609-1629. PMID: 29381782, DOI: 10.1210/en.2017-03025.Peer-Reviewed Original ResearchAnimalsATP Binding Cassette Transporter, Subfamily B, Member 1Connexin 43FemaleFetusHumansMaternal-Fetal ExchangeMiceMonoamine OxidaseOctamer Transcription Factor-3PlacentaPregnancyPregnancy Trimester, FirstPregnancy Trimester, SecondSerotoninSerotonin Plasma Membrane Transport ProteinsTrophoblastsTryptophan Hydroxylase
2008
Timing of Fetal Meconium Absorption by Amnionic Macrophages
Funai E, Labowsky A, Drewes C, Kliman H. Timing of Fetal Meconium Absorption by Amnionic Macrophages. American Journal Of Perinatology 2008, 26: 093-097. PMID: 19031358, DOI: 10.1055/s-0028-1103028.Peer-Reviewed Original Research
1994
Color Doppler flow patterns and flow velocity waveforms of the intraplacental fetal circulation in growth-retarded fetuses
Rotmensch S, Liberati M, Luo J, Kliman H, Gollin Y, Bellati U, Hobbins J, Copel J. Color Doppler flow patterns and flow velocity waveforms of the intraplacental fetal circulation in growth-retarded fetuses. American Journal Of Obstetrics And Gynecology 1994, 171: 1257-1264. PMID: 7977530, DOI: 10.1016/0002-9378(94)90143-0.Peer-Reviewed Original ResearchConceptsIntrauterine growth retardationFlow velocity waveformsUmbilical artery flow velocity waveformsColor Doppler flow signalsColor Doppler flow patternsDoppler flow signalsDoppler flow patternsVillous arteriesColor Doppler flowGrowth retardationVelocity waveformsFetal distressDoppler flowAbnormal umbilical artery flow velocity waveformsReversed end-diastolic flowDoppler flow velocity waveformsFlow signalsMedian Apgar scoresEnd-diastolic flowGrowth-retarded fetusesCross-sectional studyPulsed-wave DopplerApgar scoreColor Doppler flow imagesNormal pregnancy
1992
Fetal Fibronectin and Preterm Labor
Feinberg RF, Kliman HJ. Fetal Fibronectin and Preterm Labor. New England Journal Of Medicine 1992, 326: 708-709. PMID: 1736115, DOI: 10.1056/nejm199203053261013.Peer-Reviewed Original Research