2021
YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion
Feliciano D, Ott CM, Espinosa-Medina I, Weigel AV, Benedetti L, Milano KM, Tang Z, Lee T, Kliman HJ, Guller SM, Lippincott-Schwartz J. YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion. Nature Communications 2021, 12: 4502. PMID: 34301937, PMCID: PMC8302681, DOI: 10.1038/s41467-021-24708-2.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAMP-Activated Protein KinasesAnimalsBiological TransportCell FusionCell LineCell Line, TumorCell MembraneCell NucleusCells, CulturedGiant CellsHEK293 CellsHumansMembrane GlycoproteinsMiceRNA-SeqSignal TransductionTranscription FactorsTranscription, GeneticViral Envelope ProteinsYAP-Signaling ProteinsConceptsCell cycle arrestCell fusionNew cellular statesPlasma membrane surface areaRNA-seq analysisCell fusion systemTranscriptional programsNutrient stressCellular statesTranscriptional changesNuclear effluxCytoplasmic glucoseExtrinsic cuesUndifferentiated cellsGlucose transporterFused cellsMechanistic insightsMembrane surface areaNew functionsEndocytosisYAP1 inhibitionEnergetic stateSyncytiaCellsVSV
1990
Human trophoblast-extracellular matrix (ECM) interactions in vitro: ECM thickness modulates morphology and proteolytic activity.
Kliman HJ, Feinberg RF. Human trophoblast-extracellular matrix (ECM) interactions in vitro: ECM thickness modulates morphology and proteolytic activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 1990, 87: 3057-3061. PMID: 2326266, PMCID: PMC53833, DOI: 10.1073/pnas.87.8.3057.Peer-Reviewed Original ResearchConceptsJEG-3 human choriocarcinoma cellsMatrix degradationExtracellular matrix proteinsProteolytic activityHuman choriocarcinoma cellsExtracellular matrix degradationHuman trophoblastsCellular behaviorVascular developmentMatrix proteinsExtracellular matrix thicknessIntercellular processesMatrix interactionsUterine extracellular matrixExtracellular matrixProteolytic processesCellular morphologyUteroplacental vascular developmentChoriocarcinoma cellsECM thicknessStriking exampleMatrigelMillicell systemProteinMillicell filters
1989
The human trophoblast: homotypic and heterotypic cell-cell interactions.
Kliman HJ, Coutifaris C, Babalola GO, Soto EA, Kao LC, Queenan JT, Feinberg RF, Strauss JF. The human trophoblast: homotypic and heterotypic cell-cell interactions. Progress In Clinical And Biological Research 1989, 294: 425-34. PMID: 2726976.Peer-Reviewed Original Research