2023
Progress on the Endometrium
Frankfurter D, Kliman H. Progress on the Endometrium. Obstetrics And Gynecology Clinics Of North America 2023, 50: 677-694. PMID: 37914487, DOI: 10.1016/j.ogc.2023.09.002.Peer-Reviewed Original ResearchConceptsAbsence of pregnancyEvidence-based approachEndometrial assessmentStromal maturationEndometrial proliferationEndometrial pathologyInflammatory mediatorsOvarian steroidsImplantation failureBlastocyst implantationEndometrial sloughingDiagnostic measuresEndometriumOffer hopeDynamic tissueDevelopmental markersSingle testTissueInternal reproductionMaturationEndometriosisPregnancyDecidualizationInfertilityUterus
2021
Bone Marrow-Derived Progenitor Cells Contribute to Remodeling of the Postpartum Uterus
Tal R, Kisa J, Abuwala N, Kliman HJ, Shaikh S, Chen AY, Lyu F, Taylor HS. Bone Marrow-Derived Progenitor Cells Contribute to Remodeling of the Postpartum Uterus. Stem Cells 2021, 39: 1489-1505. PMID: 34224633, PMCID: PMC9313624, DOI: 10.1002/stem.3431.Peer-Reviewed Original ResearchConceptsPostpartum uterusEndometrial stem/progenitor cellsBone marrow-derived progenitor cellsMarrow-derived progenitor cellsF4/80 macrophage markerUterine tissue regenerationProgenitor cellsC57BL/6J female micePostpartum day 1Cytokeratin-positive epithelial cellsBlood vessel endotheliumStem/progenitor cellsPrepregnancy levelsBM transplantsEndometrial regenerationEndometrial cellsFemale miceMacrophage markersPan-leukocytesLuminal epitheliumBone marrowDay 1BMDCsUterine cellsVessel endothelium
2018
Type I interferons instigate fetal demise after Zika virus infection
Yockey LJ, Jurado KA, Arora N, Millet A, Rakib T, Milano KM, Hastings AK, Fikrig E, Kong Y, Horvath TL, Weatherbee S, Kliman HJ, Coyne CB, Iwasaki A. Type I interferons instigate fetal demise after Zika virus infection. Science Immunology 2018, 3 PMID: 29305462, PMCID: PMC6049088, DOI: 10.1126/sciimmunol.aao1680.Peer-Reviewed Original ResearchConceptsZika virus infectionZIKV infectionI IFNsI interferonType I interferonGrowth restrictionFetal demiseVirus infectionSevere fetal growth restrictionType I IFNsChorionic villous explantsAdverse fetal outcomesCongenital viral infectionFetal growth restrictionMaternal-fetal barrierType IFunctional type IPlacental damageFetal outcomesPregnancy complicationsEarly pregnancyFetal resorptionZIKV diseasePregnant damsSpontaneous abortion
2001
Maternal Hoxa10 is required for pinopod formation in the development of mouse uterine receptivity to embryo implantation
Bagot C, Kliman H, Taylor H. Maternal Hoxa10 is required for pinopod formation in the development of mouse uterine receptivity to embryo implantation. Developmental Dynamics 2001, 222: 538-544. PMID: 11747087, DOI: 10.1002/dvdy.1209.Peer-Reviewed Original ResearchConceptsEndometrial receptivityPinopod formationBlastocyst implantationHOXA10 expressionEndometrial stromal cell proliferationUterine endometrial epithelial cellsAdult female miceState of receptivityExpression of HOXA10Endometrial epithelial cellsStromal cell proliferationTime of implantationHOXA10 antisenseAdult reproductive tractEndometrial developmentGenitourinary tractFemale miceUterine receptivityMouse uterusUterusReproductive tractEpithelial cellsCell proliferationCellular proliferationHOXA10Mouse ascites golgi (MAG) mucin expression and regulation by progesterone in the rat uterus.
Schwartz LB, Naftolin F, Lyttle CR, Penzias AS, Meaddough EL, Kliman HJ. Mouse ascites golgi (MAG) mucin expression and regulation by progesterone in the rat uterus. Reproductive Sciences 2001, 8: 216-23. PMID: 11525897, DOI: 10.1016/s1071-5576(01)00115-0.Peer-Reviewed Original ResearchConceptsPregnant mare serum gonadotropinSprague-Dawley ratsEndometrial glandsAdult Sprague-Dawley ratsImmature Sprague-Dawley ratsBlood group AGlandular stainingHormonal groupsEndometrial receptivitySerum gonadotropinMucin expressionSprague-DawleyUntreated groupGroup ARat uterusMaximal responseMAG expressionBlood analysisStimulatory effectRU486Glycoprotein epitopesRatsEpitopesGlandProgesterone
2000
Uteroplacental Blood Flow The Story of Decidualization, Menstruation, and Trophoblast Invasion
Kliman H. Uteroplacental Blood Flow The Story of Decidualization, Menstruation, and Trophoblast Invasion. American Journal Of Pathology 2000, 157: 1759-1768. PMID: 11106547, PMCID: PMC1885765, DOI: 10.1016/s0002-9440(10)64813-4.Peer-Reviewed Original Research
1989
Plasminogen activator inhibitor types 1 and 2 in human trophoblasts. PAI-1 is an immunocytochemical marker of invading trophoblasts.
Feinberg RF, Kao LC, Haimowitz JE, Queenan JT, Wun TC, Strauss JF, Kliman HJ. Plasminogen activator inhibitor types 1 and 2 in human trophoblasts. PAI-1 is an immunocytochemical marker of invading trophoblasts. Laboratory Investigation 1989, 61: 20-6. PMID: 2473276.Peer-Reviewed Original ResearchConceptsPAI-2Plasminogen activator inhibitorSpecific plasminogen activator inhibitorPAI-1Villous syncytiotrophoblastHuman trophoblastsCytoplasmic localizationPlasminogen activatorRegulated productionPAI expressionCytoplasmic stainingCell surface stainingCultured cytotrophoblastsProminent cytoplasmic stainingIntervillous blood flowPlasminogen activator inhibitor type 1Activator inhibitor type 1Inhibitor type 1First trimesterActivatorProteolytic enzymesVascular remodelingVillous cytotrophoblastsBlood flowImmunohistochemical analysis