1994
Transforming growth factor-beta stimulates trophoblast oncofetal fibronectin synthesis in vitro: implications for trophoblast implantation in vivo
Feinberg RF, Kliman HJ, Wang CL. Transforming growth factor-beta stimulates trophoblast oncofetal fibronectin synthesis in vitro: implications for trophoblast implantation in vivo. The Journal Of Clinical Endocrinology & Metabolism 1994, 78: 1241-1248. PMID: 8175984, DOI: 10.1210/jcem.78.5.8175984.Peer-Reviewed Original ResearchConceptsTGF beta 1TGF betaBeta 1Ability of trophoblastsAnti-TGF betaSevere alloimmune thrombocytopeniaThird trimester placentasPlatelet-poor serumDose-response analysisPregnancy tissueCord serumAlloimmune thrombocytopeniaCytokine presentUterine deciduaExtracellular matrixVillous syncytiotrophoblastTrimester placentaNormal serumHuman cytotrophoblastsGrowth factor-beta stimulatesOncofetal fibronectinNormal morphological differentiationCulture secreteStimulatory responseThrombocytopenic serum
1992
Differentiation of the Trophoblast
Kliman H, Feinberg R. Differentiation of the Trophoblast. 1992, 3-25. DOI: 10.1007/978-3-642-84385-3_1.Peer-Reviewed Original ResearchOuter cell layersHuman trophoblastsTrophoblastic cell columnsDifferentiation pathwayUnique cellsDifferentiated functionsDifferentiation behaviorUndifferentiated cytotrophoblastsGestational ageIntermediate trophoblastSubsequent functionVillous syncytiotrophoblastCell columnVillous cytotrophoblastsHuman placentaTrophoblastCytotrophoblastsCell layerControl mechanismsBiologyDifferentiationPathwayBlastocystsPlacentaSyncytiotrophoblast
1989
Plasminogen activator inhibitor types 1 and 2 in human trophoblasts. PAI-1 is an immunocytochemical marker of invading trophoblasts.
Feinberg RF, Kao LC, Haimowitz JE, Queenan JT, Wun TC, Strauss JF, Kliman HJ. Plasminogen activator inhibitor types 1 and 2 in human trophoblasts. PAI-1 is an immunocytochemical marker of invading trophoblasts. Laboratory Investigation 1989, 61: 20-6. PMID: 2473276.Peer-Reviewed Original ResearchConceptsPAI-2Plasminogen activator inhibitorSpecific plasminogen activator inhibitorPAI-1Villous syncytiotrophoblastHuman trophoblastsCytoplasmic localizationPlasminogen activatorRegulated productionPAI expressionCytoplasmic stainingCell surface stainingCultured cytotrophoblastsProminent cytoplasmic stainingIntervillous blood flowPlasminogen activator inhibitor type 1Activator inhibitor type 1Inhibitor type 1First trimesterActivatorProteolytic enzymesVascular remodelingVillous cytotrophoblastsBlood flowImmunohistochemical analysis