2022
Sex differences in early and term placenta are conserved in adult tissues
Olney K, Plaisier S, Phung T, Silasi M, Perley L, O’Bryan J, Ramirez L, Kliman H, Wilson M. Sex differences in early and term placenta are conserved in adult tissues. Biology Of Sex Differences 2022, 13: 74. PMID: 36550527, PMCID: PMC9773522, DOI: 10.1186/s13293-022-00470-y.Peer-Reviewed Original ResearchConceptsFirst trimester placentaLate first trimesterTerm placentaTrimester placentaFirst trimesterAdult tissuesGene expressionSex differencesLifelong health outcomesSex-differential gene expressionGenetic sexInnate immune responseFull-term placentaSex-linked genesInnate immune genesImmune responsePlacenta samplesHealth outcomesBrain tissuePlacentaGametologous genesDifferent timepointsSex chromosomesImmune genesSex
2021
Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface
Lu-Culligan A, Chavan AR, Vijayakumar P, Irshaid L, Courchaine EM, Milano KM, Tang Z, Pope SD, Song E, Vogels CBF, Lu-Culligan WJ, Campbell KH, Casanovas-Massana A, Bermejo S, Toothaker JM, Lee HJ, Liu F, Schulz W, Fournier J, Muenker MC, Moore AJ, Team Y, Konnikova L, Neugebauer KM, Ring A, Grubaugh ND, Ko AI, Morotti R, Guller S, Kliman HJ, Iwasaki A, Farhadian SF. Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface. Med 2021, 2: 591-610.e10. PMID: 33969332, PMCID: PMC8084634, DOI: 10.1016/j.medj.2021.04.016.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionMaternal-fetal interfaceACE2 expressionNatural killerPregnant womenPlacental cellsAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSARS-CoV-2-infected womenTerm placentaSyndrome coronavirus 2 infectionCoronavirus 2 infectionPotential immune mechanismsRobust inflammatory responseRobust immune responseCoronavirus disease 2019Detectable viral RNAInterferon-related genesLower ACE2 expressionMajority of placentasPregnancy complicationsPlacental histologyHofbauer cellsEarly pregnancyImmune activation
1996
The effect of leukemia inhibitory factor (LIF) on trophoblast differentiation: a potential role in human implantation
Nachtigall MJ, Kliman HJ, Feinberg RF, Olive DL, Engin O, Arici A. The effect of leukemia inhibitory factor (LIF) on trophoblast differentiation: a potential role in human implantation. The Journal Of Clinical Endocrinology & Metabolism 1996, 81: 801-806. PMID: 8636307, DOI: 10.1210/jcem.81.2.8636307.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, NorthernCell DifferentiationCells, CulturedChorionic GonadotropinChorionic Gonadotropin, beta Subunit, HumanEmbryo ImplantationFemaleFibronectinsGene ExpressionGrowth InhibitorsHumansInterleukin-6Leukemia Inhibitory FactorLymphokinesPregnancyProgesteroneRNA, MessengerTrophoblastsConceptsLeukemia inhibitory factorHuman cytotrophoblastsMenstrual cycle-dependent mannerInhibitory factorOncofetal fibronectinEffects of LIFHuman implantationHuman embryonic implantationBeta-HCG mRNAOncofetal fibronectin mRNAMessenger RNA expressionExtravillous phenotypeBeta-hCGMenstrual cycleHuman endometriumNormal implantationEmbryonic implantationProgesterone productionHCG mRNATerm placentaBiochemical markersCultured trophoblastsHuman CGDay 19Steroidogenic activity
1987
Differentiaton of Human Cytotrophoblast into Syncytiotrophoblast in Culture
Kliman H, Feinman M, Strauss J. Differentiaton of Human Cytotrophoblast into Syncytiotrophoblast in Culture. Trophoblast Research 1987, 407-421. DOI: 10.1007/978-1-4757-1936-9_29.Peer-Reviewed Original ResearchHuman chorionic gonadotropinHuman placental lactogenPrevention of rejectionPatterns of hCGHuman term placentaFetal circulationMononuclear cellsProgesterone secretionChorionic gonadotropinPlacental lactogenTerm placentaHuman cytotrophoblastsImmunoglobulin transportTrophoblastImmunocytochemical localizationProtein hormonesSyncytiotrophoblastCytotrophoblastsFetusesMothersEarlier reportsMorphological changesReportSyncytial structureCells
1986
Purification, Characterization, and in vitro Differentiation of Cytotrophoblasts from Human Term Placentae*
KLIMAN H, NESTLER J, SERMASI E, SANGER J, STRAUSS J. Purification, Characterization, and in vitro Differentiation of Cytotrophoblasts from Human Term Placentae*. Endocrinology 1986, 118: 1567-1582. PMID: 3512258, DOI: 10.1210/endo-118-4-1567.Peer-Reviewed Original ResearchConceptsHuman term placentaTerm placentaImmunoperoxidase methodHCG-positive cellsOccasional single cellsPregnancy-specific beta 1Human placental lactogenPercoll gradient centrifugation stepDifferentiation of cytotrophoblastsPregnancy-specific betaFunctional syncytiotrophoblastsPlacental lactogenSyncytial groupsCultured trophoblastsHuman cytotrophoblastsOccasional cellsProgesterone synthesisSyncytial trophoblastHCGEndothelial cellsBeta 1CytotrophoblastsTrophoblastTime pointsPlacenta