2016
An Important Role of Pumilio 1 in Regulating the Development of the Mammalian Female Germline1
Mak W, Fang C, Holden T, Dratver MB, Lin H. An Important Role of Pumilio 1 in Regulating the Development of the Mammalian Female Germline1. Biology Of Reproduction 2016, 94: 134, 1-11. PMID: 27170441, PMCID: PMC4946805, DOI: 10.1095/biolreprod.115.137497.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDNA-Binding ProteinsFemaleMice, TransgenicNuclear ProteinsOocytesOogenesisOvarian FollicleReproductionRNA-Binding ProteinsConceptsPumilio 1PUF proteinsLate meiotic prophase IPumilio/FBF (PUF) proteinReproductive competencyPrimordial follicle poolFemale germ cell developmentMammalian germ cellsPrimordial folliculogenesisFemale reproductive competenceMeiotic prophase IGerm cell developmentFBF proteinsGermline establishmentTranslational regulatorTranslational regulationProphase IDiplotene stageCell developmentGerm cellsFollicle poolImportant roleDetectable functionMammalsReproductive competence
2015
Reassessment of Piwi Binding to the Genome and Piwi Impact on RNA Polymerase II Distribution
Lin H, Chen M, Kundaje A, Valouev A, Yin H, Liu N, Neuenkirchen N, Zhong M, Snyder M. Reassessment of Piwi Binding to the Genome and Piwi Impact on RNA Polymerase II Distribution. Developmental Cell 2015, 32: 772-774. PMID: 25805139, PMCID: PMC4472434, DOI: 10.1016/j.devcel.2015.03.004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArgonaute ProteinsBase SequenceBinding SitesChromatin ImmunoprecipitationChromobox Protein Homolog 5Chromosomal Proteins, Non-HistoneDNA-Binding ProteinsDrosophila melanogasterDrosophila ProteinsGenomeHigh-Throughput Nucleotide SequencingHistone MethyltransferasesHistone-Lysine N-MethyltransferaseMethyltransferasesRNA InterferenceRNA Polymerase IIRNA, Small InterferingSequence Analysis, DNAConceptsRNA polymerase II distributionGenomic targetsHeterochromatin protein 1aRNA polymerase IICurrent bioinformatics methodsPiwi mutantsDrosophila PiwiPolymerase IIDevelopmental cellsPericentric regionsHistone methyltransferaseBioinformatics methodsBioinformatics pipelineProtein 1APiwiGenomePiRNAsEuchromatinMutantsMethyltransferaseSites
2010
A Drosophila Chromatin Factor Interacts With the Piwi-Interacting RNA Mechanism in Niche Cells to Regulate Germline Stem Cell Self-Renewal
Smulders-Srinivasan TK, Szakmary A, Lin H. A Drosophila Chromatin Factor Interacts With the Piwi-Interacting RNA Mechanism in Niche Cells to Regulate Germline Stem Cell Self-Renewal. Genetics 2010, 186: 573-583. PMID: 20647505, PMCID: PMC2954472, DOI: 10.1534/genetics.110.119081.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArgonaute ProteinsChromatinChromosomal Proteins, Non-HistoneDNA-Binding ProteinsDrosophilaDrosophila ProteinsEpigenesis, GeneticFemaleGerm CellsHedgehog ProteinsMalePolycomb-Group ProteinsPolymerase Chain ReactionRepressor ProteinsRNA, Small InterferingRNA-Induced Silencing ComplexSignal TransductionStem Cell NicheStem CellsConceptsGermline stem cellsNiche cellsEpigenetic programmingStem Cell Self-RenewalEnhancer of PolycombTrithorax group genesPotential genetic interactionsCell Self-RenewalNovel epigenetic mechanismStem cellsDrosophila ovaryGSC divisionChromatin factorsNiche signalingChromatin proteinsGenetic interactionsPiwi expressionStem cell defectEpigenetic regulationPiwiEpigenetic mechanismsGroup genesRNA mechanismExpression of hedgehogSelf-Renewal
2002
miwi, a Murine Homolog of piwi, Encodes a Cytoplasmic Protein Essential for Spermatogenesis
Deng W, Lin H. miwi, a Murine Homolog of piwi, Encodes a Cytoplasmic Protein Essential for Spermatogenesis. Developmental Cell 2002, 2: 819-830. PMID: 12062093, DOI: 10.1016/s1534-5807(02)00165-x.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsArgonaute ProteinsChromosome MappingCloning, MolecularCyclic AMP Response Element ModulatorCytoplasmDNA-Binding ProteinsGene Expression RegulationInfertility, MaleLIM Domain ProteinsMaleMiceMice, KnockoutMolecular Sequence DataProtein IsoformsProteinsRepressor ProteinsRNA, MessengerSpermatogenesisTestisTranscription FactorsConceptsTarget genesPiwi family genesCytoplasmic protein essentialRound spermatid stageDiverse organismsPiwi genesTranslational regulationFamily genesProtein essentialCytoplasmic proteinsMaster regulatorMurine homologMIWIGenesSpermatid stageStem cellsMRNASpermiogenesisCREMSpermatogenesisSpermatogenic arrestPiwiHomologEncodesCloning