2021
Prognostic impact of mismatch repair deficiency in high- and low-intermediate-risk, early-stage endometrial cancer following vaginal brachytherapy
Li JY, Park HS, Huang GS, Young MR, Ratner E, Santin A, Damast S. Prognostic impact of mismatch repair deficiency in high- and low-intermediate-risk, early-stage endometrial cancer following vaginal brachytherapy. Gynecologic Oncology 2021, 163: 557-562. PMID: 34602287, DOI: 10.1016/j.ygyno.2021.09.018.Peer-Reviewed Original ResearchConceptsRecurrence-free survivalEndometrioid endometrial cancerVaginal brachytherapyPMMR patientsOverall survivalEEC patientsEndometrial cancerExact testThree-year recurrence-free survivalEarly-stage endometrial cancerCox proportional hazards regressionPoor recurrence-free survivalAdjuvant vaginal brachytherapyThree-year OSMultivariable Cox regressionLympho-vascular invasionSignificant prognostic variablesProportional hazards regressionLog-rank testKaplan-Meier estimatesDeficient mismatch repairMismatch repair statusFisher's exact testMismatch repair deficiencyDMMR status
2019
Neutrophilia and mortality in women with uterine carcinosarcoma
Arend R, Van Arsdale A, Gojayev A, Roane BM, Doo D, Leath C, Goldberg GL, Huang G. Neutrophilia and mortality in women with uterine carcinosarcoma. International Journal Of Gynecological Cancer 2019, 29: 1258. PMID: 31320488, DOI: 10.1136/ijgc-2019-000440.Peer-Reviewed Original ResearchConceptsPre-treatment absolute neutrophil countAbsolute neutrophil countIndependent poor prognostic factorProgression-free survivalPoor prognostic factorNeutrophil countUterine carcinosarcomaOverall survivalPrognostic factorsMultivariable Cox proportional hazards regression modelsCox proportional hazards regression modelAbsolute neutrophil count dataHigher absolute neutrophil countKaplan-Meier survival estimatesProportional hazards regression modelsUterine carcinosarcoma patientsRetrospective cohort studyHazards regression modelsLog-rank testInstitutional review boardCarcinosarcoma patientsCohort studyDisease recurrenceClinical outcomesHighest quartile
2018
Insulin‐like growth factor 2: a poor prognostic biomarker linked to racial disparity in women with uterine carcinosarcoma
Van Arsdale AR, Arend RC, Cossio MJ, Erickson BK, Wang Y, Doo DW, Leath CA, Goldberg GL, Huang GS. Insulin‐like growth factor 2: a poor prognostic biomarker linked to racial disparity in women with uterine carcinosarcoma. Cancer Medicine 2018, 7: 616-625. PMID: 29455465, PMCID: PMC5852335, DOI: 10.1002/cam4.1335.Peer-Reviewed Original ResearchConceptsProgression-free survivalOverall survivalUterine carcinosarcomaHigh IGF2IGF2 levelsMultivariable Cox proportional hazards regression modelsCox proportional hazards regression modelRace-stratified multivariable analysesProportional hazards regression modelsReduced progression-free survivalInsulin-like growth factor 2 expressionRacial disparitiesIndependent risk factorEarly-stage diseaseRisk of deathHazards regression modelsPoor prognostic biomarkerGrowth factor 2 expressionFactor 2 (Nrf2) protein expressionFactor 2 expressionBlack womenAdjuvant therapyWhite patientsMultivariable analysisBlack race
2011
Performance of Serum CA125 as a Prognostic Biomarker in Patients With Uterine Papillary Serous Carcinoma
Gupta D, Gunter MJ, Yang K, Lee S, Zuckerwise L, Chen LM, Goldberg GL, Huang GS. Performance of Serum CA125 as a Prognostic Biomarker in Patients With Uterine Papillary Serous Carcinoma. International Journal Of Gynecological Cancer 2011, 21: 529-534. PMID: 21436701, DOI: 10.1097/igc.0b013e31821091b5.Peer-Reviewed Original ResearchConceptsUterine papillary serous carcinomaPapillary serous carcinomaCA125 levelsLymph node metastasisDisease recurrenceCA125 elevationMetastatic diseaseNode metastasisSerum CA125Serous carcinomaStage III/IV diseaseCox proportional hazards regression modelingProportional hazards regression modelingElevated CA125 levelsPreoperative CA125 levelsLymph node involvementRecurrence-free survivalAdvanced International FederationMultivariate survival analysisUPSC patientsMean followSurgical stagingCA125 measurementNode involvementIndependent predictors
2010
Insulin-like Growth Factor 2 Expression Modulates Taxol Resistance and Is a Candidate Biomarker for Reduced Disease-Free Survival in Ovarian Cancer
Huang GS, Brouwer-Visser J, Ramirez MJ, Kim CH, Hebert TM, Lin J, Arias-Pulido H, Qualls CR, Prossnitz ER, Goldberg GL, Smith HO, Horwitz SB. Insulin-like Growth Factor 2 Expression Modulates Taxol Resistance and Is a Candidate Biomarker for Reduced Disease-Free Survival in Ovarian Cancer. Clinical Cancer Research 2010, 16: 2999-3010. PMID: 20404007, PMCID: PMC2887721, DOI: 10.1158/1078-0432.ccr-09-3233.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Agents, PhytogenicBiomarkers, TumorCell Line, TumorCell ProliferationDisease-Free SurvivalDrug Resistance, NeoplasmFemaleGene Knockdown TechniquesHumansInsulin-Like Growth Factor IIOvarian NeoplasmsPaclitaxelPhosphorylationPrognosisProto-Oncogene Proteins c-aktPyrimidinesPyrrolesReceptor, IGF Type 1RNA, Small InterferingSignal TransductionConceptsEpithelial ovarian tumorsInsulin-like growth factorDisease-free survivalOvarian carcinoma cellsOvarian tumorsTaxol resistancePathway inhibitionIGF2 expressionOvarian cancerCarcinoma cellsExact testReduced disease-free survivalHuman epithelial ovarian tumorsCandidate prognostic biomarkerDrug-resistant ovarian carcinoma cellsUpregulation of IGF2Fisher's exact testIGF2 protein expressionOvarian cancer cellsDrug-resistant phenotypeHigh IGF2 expressionIGF receptor inhibitorsPathologic factorsTaxol-resistant cell linesCox regression