2022
Effect of chemotherapy on the uterus of young adult cancer survivors
Garg D, Hodgman M, Reil S, Lomo L, Aston K, Hill J, Johnstone E, Jenkins T, Letourneau J. Effect of chemotherapy on the uterus of young adult cancer survivors. F&S Reports 2022, 3: 198-203. PMID: 36212573, PMCID: PMC9532891, DOI: 10.1016/j.xfre.2022.05.008.Peer-Reviewed Original ResearchEndometrial thicknessChemotherapy exposureEndometrial biopsyUterine volumeCancer survivorsHodgkin's lymphomaMenstrual cycleDeoxyribonucleic acid (DNA) methylation patternsCross-sectional pilot studyYoung adult cancer survivorsImpact of chemotherapyRibonucleic acid expression levelsEffect of chemotherapyAdult cancer survivorsGeneral population controlsLate proliferative phaseMedian uterine volumeUniversity fertility clinicPelvic radiationEndometrial histologyPelvic ultrasoundCervical cancerFalse-positive resultsMenstruating womenStudy visit
2021
EFFECT OF ALKYLATING AGENT CHEMOTHERAPY ON THE UTERUS OF YOUNG ADULT CANCER SURVIVORS
Garg D, Jenkins T, Johnstone E, Aston K, Letourneau J. EFFECT OF ALKYLATING AGENT CHEMOTHERAPY ON THE UTERUS OF YOUNG ADULT CANCER SURVIVORS. Fertility And Sterility 2021, 116: e474. DOI: 10.1016/j.fertnstert.2021.08.028.Peer-Reviewed Original ResearchCancer treatment is associated with a measurable decrease in live births in a large, population-based study
Garg D, Meeks H, Johnstone E, Berga S, Smith K, Hotaling J, Letourneau J. Cancer treatment is associated with a measurable decrease in live births in a large, population-based study. F&S Reports 2021, 2: 462-467. PMID: 34934988, PMCID: PMC8655402, DOI: 10.1016/j.xfre.2021.08.004.Peer-Reviewed Original ResearchIncidence rate ratiosPopulation-based studyLive birth rateAge-matched controlsLive birthsCancer survivorsCancer typesHealthy controlsBreast cancerLower live birth ratesCancer treatmentCentral nervous system cancerRetrospective cohort studyFemale cancer patientsNon-cancer controlsNervous system cancersAge 18 yearsCommon cancer typesSoft tissue cancerBirth rateCohort studyGastrointestinal cancerCancer patientsSystem cancersMAIN OUTCOME
2020
LIKELIHOOD OF WOMEN ACHIEVING MORE THAN ONE LIVE BIRTH AFTER VARIOUS TYPES OF CANCERS
Garg D, Meeks H, Johnstone E, Berga S, Smith K, Hotaling J, Letourneau J. LIKELIHOOD OF WOMEN ACHIEVING MORE THAN ONE LIVE BIRTH AFTER VARIOUS TYPES OF CANCERS. Fertility And Sterility 2020, 114: e253. DOI: 10.1016/j.fertnstert.2020.10.012.Peer-Reviewed Original ResearchLooking beyond the ovary for oncofertility care in women: uterine injury as a potential target for fertility-preserving treatments
Garg D, Johnstone E, Lomo L, Fair D, Rosen M, Taylor R, Silver B, Letourneau J. Looking beyond the ovary for oncofertility care in women: uterine injury as a potential target for fertility-preserving treatments. Journal Of Assisted Reproduction And Genetics 2020, 37: 1467-1476. PMID: 32342270, PMCID: PMC7311602, DOI: 10.1007/s10815-020-01792-9.Peer-Reviewed Original ResearchConceptsCancer survivorsPregnancy complicationsObstetrical outcomesFertility-preserving treatmentLow birth weightPoor obstetrical outcomesFemale cancer survivorsImpact of chemotherapyEarly pregnancy lossOncofertility carePregnancy implantationLate complicationsPregnancy outcomesPreterm birthRadiation fibrosisEndometrial receptivityGonadotoxic effectsUterine injuryBirth weightPregnancy lossPregnant uterusBlood supplyUterine functionChemotherapyComplicationsMP26-10 PATERNAL CANCER HISTORY DOES NOT INCREASE OBSTETRIC COMPLICATIONS
Gross* K, Meeks H, Garg D, Patel D, Pastuszak A, Hanson H, Smith K, Letourneau J, Hotaling J. MP26-10 PATERNAL CANCER HISTORY DOES NOT INCREASE OBSTETRIC COMPLICATIONS. Journal Of Urology 2020, 203 DOI: 10.1097/ju.0000000000000865.010.Peer-Reviewed Original ResearchMP26-09 MEN WITH CANCER DIAGNOSIS ARE OLDER AT TIME OF FIRST LIVE BIRTH:AN AGE-MATCHED COHORT ANALYSIS OF THE UTAH POPULATION DATABASE
Patel* D, Meeks H, Garg D, Gross K, Pastuszak A, Hanson H, Smith K, Letourneau J, Hotaling J. MP26-09 MEN WITH CANCER DIAGNOSIS ARE OLDER AT TIME OF FIRST LIVE BIRTH:AN AGE-MATCHED COHORT ANALYSIS OF THE UTAH POPULATION DATABASE. Journal Of Urology 2020, 203 DOI: 10.1097/ju.0000000000000865.09.Peer-Reviewed Original ResearchPD25-06 MEN WITH PREVIOUS CANCER DIAGNOSIS HAVE LOWER PARITY: A CASE-CONTROL ANALYSIS OF THE UTAH POPULATION DATABASE
Gross* K, Meeks H, Garg D, Patel D, Pastuszak A, Hanson H, Smith K, Letourneau J, Hotaling J. PD25-06 MEN WITH PREVIOUS CANCER DIAGNOSIS HAVE LOWER PARITY: A CASE-CONTROL ANALYSIS OF THE UTAH POPULATION DATABASE. Journal Of Urology 2020, 203 DOI: 10.1097/ju.0000000000000882.06.Peer-Reviewed Original ResearchTHE POTENTIAL IMPACT OF CANCER TREATMENT ON LIVE BIRTHS IN MEN AND WOMEN IN A LARGE POPULATION-BASED STUDY
Garg D, Meeks H, Johnstone E, Pastuszak A, Berga S, Smith K, Hotaling J, Letourneau J. THE POTENTIAL IMPACT OF CANCER TREATMENT ON LIVE BIRTHS IN MEN AND WOMEN IN A LARGE POPULATION-BASED STUDY. Fertility And Sterility 2020, 113: e4. DOI: 10.1016/j.fertnstert.2020.02.009.Peer-Reviewed Original ResearchChapter 1 Neuroendocrine mechanisms of reproduction
Garg D, Berga SL. Chapter 1 Neuroendocrine mechanisms of reproduction. Handbook Of Clinical Neurology 2020, 171: 3-23. PMID: 32736757, DOI: 10.1016/b978-0-444-64239-4.00001-1.Peer-Reviewed Original ResearchConceptsGnRH driveNeuroendocrinology of reproductionReproductive functionFunctional hypothalamic amenorrheaSex steroid hormone synthesisFollicle-stimulating hormoneGonadotropin-releasing hormoneStress-induced anovulationSteroid hormone synthesisAbsence of oocytesHypothalamic amenorrheaHypothalamic hypogonadismCongenital causesCeliac diseaseMenstrual cyclePsychogenic amenorrheaCommon causeGonadal axisEndocrine effectsAnterior pituitaryBrain tumorsBehavioral variablesSecondary insufficiencyAppropriate secretionNeuroendocrine mechanisms
2019
Cancer treatment is associated with a measurable decrease in live births in a large, population-based study
Garg D, Meeks H, Johnstone E, Pastuszak A, Berga S, Smith K, Hotaling J, Letourneau J. Cancer treatment is associated with a measurable decrease in live births in a large, population-based study. Fertility And Sterility 2019, 112: e22. DOI: 10.1016/j.fertnstert.2019.07.190.Peer-Reviewed Original ResearchPregnancy outcomes among cancer survivors: a population-based analysis
Garg D, Meeks H, Johnstone E, Pastuszak A, Berga S, Smith K, Hotaling J, Letourneau J. Pregnancy outcomes among cancer survivors: a population-based analysis. Fertility And Sterility 2019, 112: e22. DOI: 10.1016/j.fertnstert.2019.07.191.Peer-Reviewed Original ResearchDescribing live births after cancer treatments: when do patients conceive and how many children do they have? a population-based study in the Western United States
Garg D, Meeks H, Johnstone E, Pastuszak A, Berga S, Smith K, Hotaling J, Letourneau J. Describing live births after cancer treatments: when do patients conceive and how many children do they have? a population-based study in the Western United States. Fertility And Sterility 2019, 112: e23. DOI: 10.1016/j.fertnstert.2019.07.193.Peer-Reviewed Original ResearchThe potential impact of newer chemotherapy regimens on future fertility in men and women treated for lymphoma
Garg D, Kohn T, Pastuszak A, Letourneau J, Hotaling J. The potential impact of newer chemotherapy regimens on future fertility in men and women treated for lymphoma. Fertility And Sterility 2019, 112: e21-e22. DOI: 10.1016/j.fertnstert.2019.07.189.Peer-Reviewed Original ResearchOncofertility conundrum: discrepancy between anti-Mϋllerian hormone and mature oocyte yield in a peripubertal girl with Hodgkin lymphoma
Garg D, Johnstone E, Fair D, Carrell D, Berga S, Letourneau J. Oncofertility conundrum: discrepancy between anti-Mϋllerian hormone and mature oocyte yield in a peripubertal girl with Hodgkin lymphoma. Journal Of Assisted Reproduction And Genetics 2019, 36: 1753-1756. PMID: 31313012, PMCID: PMC6708038, DOI: 10.1007/s10815-019-01516-8.Peer-Reviewed Original Research
2017
Treatment Modalities for Fibroids, Indications, Risks, and Benefits
Garg D, Segars J. Treatment Modalities for Fibroids, Indications, Risks, and Benefits. 2017, 87-106. DOI: 10.1007/978-3-319-58780-6_3.Peer-Reviewed Original ResearchTreatment modalitiesUterine fibroidsGonadotropin-releasing hormone agonistInvasive surgeryInterventional radiological approachAbnormal uterine bleedingTreatment of fibroidsManagement of fibroidsNew treatment optionsSize of fibroidsCommon benign neoplasmInterventional radiological proceduresFibroid managementAbdominal painHormonal therapyUrinary frequencyUterine bleedingProcedural indicationsPressure symptomsAbdominal girthHormone agonistMedical managementPatient's symptomsSurgical managementClinical manifestationsCorrelation between follicular fluid levels of sRAGE and vitamin D in women with PCOS
Garg D, Grazi R, Lambert-Messerlian GM, Merhi Z. Correlation between follicular fluid levels of sRAGE and vitamin D in women with PCOS. Journal Of Assisted Reproduction And Genetics 2017, 34: 1507-1513. PMID: 28825156, PMCID: PMC5699991, DOI: 10.1007/s10815-017-1011-6.Peer-Reviewed Original ResearchConceptsAdvanced glycation end productsFollicular fluidVitamin DPro-inflammatory advanced glycation end productsHigher anti-Mullerian hormone levelsAnti-Mullerian hormone levelsProtective anti-inflammatory roleFollicular fluid levelsLevels of sRAGEAnti-inflammatory rolePathogenesis of PCOSGlycation end productsPotential therapeutic targetDay 5 embryosConclusionsIn womenSRAGE levelsOvarian dysfunctionOvarian levelHormone levelsPCOSSRAGESoluble receptorTherapeutic targetDay 3Fluid levelsProgesterone-Mediated Non-Classical Signaling
Garg D, Ng S, Baig K, Driggers P, Segars J. Progesterone-Mediated Non-Classical Signaling. Trends In Endocrinology And Metabolism 2017, 28: 656-668. PMID: 28651856, DOI: 10.1016/j.tem.2017.05.006.Peer-Reviewed Original ResearchConceptsProgesterone response elementGrowth factor signalingNon-genomic signalingNon-classical signaling pathwaysNon-classical signalingCycle regulationFactor signalingSignaling pathwaysResponse elementProgesterone signalingCell growthSignalingProgesterone receptorSubsequent activationNovel therapeutic strategiesHormone actionProgesterone actionPathwayGrowth factorImportant physiological actionsPhysiological actionsMenstrual cycle regulationNuclear progesterone receptorRecent studiesActivation
2016
Febrile Morbidity After Robotic versus Abdominal Myomectomy
Garg D, Tang N, Homel P, Ricardo M, Bral P. Febrile Morbidity After Robotic versus Abdominal Myomectomy. Journal Of Minimally Invasive Gynecology 2016, 23: s22. DOI: 10.1016/j.jmig.2016.08.063.Peer-Reviewed Original ResearchRelationship between Advanced Glycation End Products and Steroidogenesis in PCOS
Garg D, Merhi Z. Relationship between Advanced Glycation End Products and Steroidogenesis in PCOS. Reproductive Biology And Endocrinology 2016, 14: 71. PMID: 27769286, PMCID: PMC5073880, DOI: 10.1186/s12958-016-0205-6.Peer-Reviewed Original ResearchMeSH Keywords3-Hydroxysteroid DehydrogenasesAnimalsCholesterol Side-Chain Cleavage EnzymeFemaleGlycation End Products, AdvancedGonadal Steroid HormonesGranulosa CellsHumansOvaryPhosphoproteinsPolycystic Ovary SyndromeReceptors, LHReceptors, PeptideReceptors, Transforming Growth Factor betaSteroid 17-alpha-HydroxylaseTheca CellsConceptsAdvanced glycation end productsOvaries of womenTheca cell functionGlycation end productsCell functionHormone receptor expressionSteroidogenic enzyme activitiesSteroidogenic acute regulatory proteinAbnormal steroidogenesisPCOS modelOvarian dysfunctionAcute regulatory proteinReceptor expressionPCOSFollicular developmentTheca cellsGranulosa cellsSystematic reviewNew interventionsHormone receptorsEnzyme cytochrome P450SteroidogenesisEnd productsGranulosaCytochrome P450