2022
A Bedside Test to Detect the Presence of Embryonic or Fetal Tissue in Vaginal Blood
Volovsky M, Ayala M, Narayanamoorthy S, Chiware T, Kotlyar A, Taylor H, Seifer D, Mor A. A Bedside Test to Detect the Presence of Embryonic or Fetal Tissue in Vaginal Blood. Obstetrics And Gynecology 2022, 140: 983-988. PMID: 36357961, DOI: 10.1097/aog.0000000000004975.Peer-Reviewed Original ResearchConceptsVaginal bloodEctopic pregnancyPositive control groupAlpha-fetoproteinControl groupFetal tissuesNegative control groupComplete miscarriageIGFBP-1Bedside testStudy groupInsulin-like growth factor-binding protein-1Growth factor-binding protein-1First-trimester bleedingProspective cohort studyRapid bedside testIntrauterine pregnancyVaginal bleedingCohort studyNonpregnant individualsReproductive-aged individualsPregnant individualsRapid test stripPregnancyMiscarriage
1999
Diagnosis of acute and persistent ectopic pregnancy.
Graczykowski JW, Seifer DB. Diagnosis of acute and persistent ectopic pregnancy. Clinical Obstetrics & Gynecology 1999, 42: 9-22; quiz 55-6. PMID: 10073295, DOI: 10.1097/00003081-199903000-00005.Peer-Reviewed Original Research
1997
Persistent ectopic pregnancy: an argument for heightened vigilance and patient compliance
Seifer D. Persistent ectopic pregnancy: an argument for heightened vigilance and patient compliance. Fertility And Sterility 1997, 68: 402-404. PMID: 9314904, DOI: 10.1016/s0015-0282(97)00271-9.Peer-Reviewed Original Research
1996
Serum inhibin levels are lower in ectopic than intrauterine spontaneously conceived pregnancies*†*Presented in part at the 42nd Annual Meeting of the Society for Gynecological Investigation, Chicago, Illinois, March 15 to 18, 1995.†Supported in part by Physician Scientist Award from National Institutes of Health, National Institute on Aging grant AG00566 (D.B.S.) and HD29164 (G.M.L.M., A.L.S.).
Seifer D, Lambert-Messerlian G, Canick J, Frishman G, Schneyer A. Serum inhibin levels are lower in ectopic than intrauterine spontaneously conceived pregnancies*†*Presented in part at the 42nd Annual Meeting of the Society for Gynecological Investigation, Chicago, Illinois, March 15 to 18, 1995.†Supported in part by Physician Scientist Award from National Institutes of Health, National Institute on Aging grant AG00566 (D.B.S.) and HD29164 (G.M.L.M., A.L.S.). Fertility And Sterility 1996, 65: 667-669. PMID: 8774307, DOI: 10.1016/s0015-0282(16)58174-6.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesChorionic GonadotropinFemaleHumansInhibinsOsmolar ConcentrationPregnancyPregnancy, EctopicProgesteroneReference ValuesConceptsIntrauterine pregnancySerum inhibin concentrationsDimeric inhibinInhibin concentrationsTotal inhibinMaternal serumSerum samplesDimeric inhibin concentrationSingle intrauterine pregnancySerum inhibin levelsCase-control studyAcademic clinical practiceNational InstituteAlpha-inhibin subunitGynecological InvestigationInhibin levelsSonographic evidenceGestational ageInhibin subunitsWeek 8MAIN OUTCOMEClinical practiceInhibinEctopicWomen
1995
Laparoscopic management of ectopic pregnancy
Grainger D, Seifer D. Laparoscopic management of ectopic pregnancy. Current Opinion In Obstetrics & Gynecology 1995, 7: 277-282. PMID: 7578967, DOI: 10.1097/00001703-199508000-00009.Peer-Reviewed Original ResearchConceptsEctopic pregnancySerum beta-human chorionic gonadotropinBeta-human chorionic gonadotropinPersistent ectopic pregnancyUse of methotrexateAlgorithm of diagnosisInvolved tubeLaparoscopic managementSurgical managementTransvaginal ultrasoundLocal injectionChorionic gonadotropinEarly diagnosisHigh indexPregnancyDiagnosisPatientsSurgeryGonadotropinMethotrexateManagementSuspicion
1994
Reproductive potential after treatment for persistent ectopic pregnancy **Presented in part at the conjoint meeting of The American Fertility Society and the Canadian Fertility and Andrology Society, Montreal, Quebec, Canada, October 11 to 14, 1993.
Seifer D, Silva P, Grainger D, Barber S, Grant W, Gutmann J. Reproductive potential after treatment for persistent ectopic pregnancy **Presented in part at the conjoint meeting of The American Fertility Society and the Canadian Fertility and Andrology Society, Montreal, Quebec, Canada, October 11 to 14, 1993. Fertility And Sterility 1994, 62: 194-196. PMID: 8005291, DOI: 10.1016/s0015-0282(16)56841-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleHumansMethotrexatePregnancyPregnancy, EctopicReproductionSalpingostomyTime FactorsTreatment OutcomeConceptsContralateral fallopian tubeClinical pregnancy rateFallopian tubePregnancy rateCumulative clinical pregnancy rateIntrauterine pregnancy ratePersistent ectopic pregnancyAmerican Fertility SocietyClinical pregnancyEctopic pregnancyTreatment failureCanadian FertilityAndrology SocietySuccessful treatmentPrimary treatmentFertility SocietyRelative riskReproductive outcomesConjoint MeetingObvious pathologySignificant associationSuccess rateTreatmentPregnancySalpingectomyUrine hCG beta-subunit core fragment, a sensitive test for ectopic pregnancy
Cole LA, Kardana A, Seifer DB, Bohler HC. Urine hCG beta-subunit core fragment, a sensitive test for ectopic pregnancy. The Journal Of Clinical Endocrinology & Metabolism 1994, 78: 497-499. PMID: 7508952, DOI: 10.1210/jcem.78.2.7508952.Peer-Reviewed Original ResearchConceptsTubal pregnancyBeta-core fragmentEmergency roomIntrauterine pregnancyEctopic pregnancyPregnancy levelsUrine samplesNormal levelsNormal intrauterine pregnancyPregnancy serum samplesMicrograms/LPregnancy concentrationsHCG levelsNormal pregnancyAdditional patientsBeta immunoreactivityHCG testPregnancy samplesPregnancyMedian levelsPredictive valueHCGSerum samplesGlycoprotein hormonesSensitive test
1993
Hematosalpinx after methotrexate treatment of unruptured ectopic pregnancy
Frishman G, Seifer D. Hematosalpinx after methotrexate treatment of unruptured ectopic pregnancy. Fertility And Sterility 1993, 60: 571-572. PMID: 8375544, DOI: 10.1016/s0015-0282(16)56178-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultBloodFallopian TubesFemaleHumansLaparoscopyMethotrexatePregnancyPregnancy, EctopicUltrasonographyUterine Diseases
1991
Persistent Ectopic Pregnancy
Seifer D, Diamond M, DeCherney A. Persistent Ectopic Pregnancy. Obstetrics And Gynecology Clinics Of North America 1991, 18: 153-159. PMID: 1923255, DOI: 10.1016/s0889-8545(21)00492-7.Peer-Reviewed Original Research
1990
Persistent ectopic pregnancy following laparoscopic linear salpingostomy.
Seifer DB, Gutmann JN, Doyle MB, Jones EE, Diamond MP, DeCherney AH. Persistent ectopic pregnancy following laparoscopic linear salpingostomy. Obstetrics And Gynecology 1990, 76: 1121-5. PMID: 1700350.Peer-Reviewed Original ResearchConceptsPersistent ectopic pregnancyEctopic pregnancyLaparoscopic salpingostomyMultivariate stepwise logistic regressionYale-New Haven HospitalBeta-hCG titersClose postoperative surveillanceLaparoscopic linear salpingostomyDays of amenorrheaStepwise logistic regressionIpsilateral tubeLinear salpingostomyPostoperative surveillanceRepeat surgerySurgical approachComplete salpingectomySalpingostomyPregnancyConservative proceduresLogistic regressionParticular cautionPatientsEctopicWomenSalpingectomy