Featured Publications
Racial and Ethnic Disparities in Access to and Outcomes of Infertility Treatment and Assisted Reproductive Technology in the United States
Beroukhim G, Seifer D. Racial and Ethnic Disparities in Access to and Outcomes of Infertility Treatment and Assisted Reproductive Technology in the United States. Endocrinology And Metabolism Clinics Of North America 2023, 52: 659-675. PMID: 37865480, DOI: 10.1016/j.ecl.2023.05.005.Peer-Reviewed Original ResearchMeSH KeywordsAmerican Indian or Alaska NativeAsianBlack or African AmericanEthnicityFemaleHealth Services AccessibilityHealthcare DisparitiesHispanic or LatinoHumansInfertilityInfertility, FemalePregnancyPregnancy OutcomeReproductive Techniques, AssistedSocial Determinants of HealthUnited StatesWhiteConceptsEthnic disparitiesInfertility treatmentIntrauterine insemination pregnancy ratesHigh infertility rateAmerican Indian womenAssisted Reproductive TechnologyClinical pregnancyObstetrical complicationsFertility carePregnancy lossFavorable outcomePregnancy rateInfertility rateLive birthsHigher oddsART outcomesHispanic womenWhite womenRobust studiesWomenIndian womenReproductive technologiesBlack womenOutcomesCare
2023
Effect of state insurance mandates on racial/ethnic disparities in the utilization and outcomes of donor oocyte–assisted reproductive technologies
Liao C, Kotlyar A, Seifer D. Effect of state insurance mandates on racial/ethnic disparities in the utilization and outcomes of donor oocyte–assisted reproductive technologies. Fertility And Sterility 2023, 120: 111-122. PMID: 36871857, DOI: 10.1016/j.fertnstert.2023.02.037.Peer-Reviewed Original ResearchConceptsBody mass indexUterine factor infertilityBlack recipientsART cyclesHispanic recipientsWhite recipientsEthnic disparitiesState insurance mandatesFactor infertilityMass indexAsian recipientsOocyte recipientsDonor oocytesLive birthsAssisted Reproductive Technology Clinic Outcome Reporting SystemRetrospective cohort studyCumulative probabilityRecurrent pregnancy lossMultivariable Poisson regressionFrozen-thawed transfersReproductive technologiesHigher median agePreimplantation genetic testingNon-Hispanic whitesInsurance mandates
2022
Fertility Counseling beyond 40
Mor A, Seifer D. Fertility Counseling beyond 40. 2022, 98-105. DOI: 10.1017/9781009025270.009.Peer-Reviewed Original Research
2020
Correction to: Status of racial disparities between black and white women undergoing assisted reproductive technology in the US
Seifer DB, Simsek B, Wantman E, Kotlyar AM. Correction to: Status of racial disparities between black and white women undergoing assisted reproductive technology in the US. Reproductive Biology And Endocrinology 2020, 18: 125. PMID: 33349258, PMCID: PMC7751097, DOI: 10.1186/s12958-020-00683-z.Peer-Reviewed Original ResearchStatus of racial disparities between black and white women undergoing assisted reproductive technology in the US
Seifer D, Simsek B, Wantman E, Kotlyar A. Status of racial disparities between black and white women undergoing assisted reproductive technology in the US. Reproductive Biology And Endocrinology 2020, 18: 113. PMID: 33213467, PMCID: PMC7677830, DOI: 10.1186/s12958-020-00662-4.Peer-Reviewed Original ResearchConceptsCumulative live birth rateLive birth rateReproductive technology outcomesWhite non-Hispanic womenBody mass indexEtiology of infertilityNon-Hispanic womenMass indexBirth rateBlack womenWhite non-Hispanic patientsTechnology outcomesLogistic regressionWhite womenRetrospective cohort studyNon-Hispanic patientsIndependent prognostic factorIntra-cytoplasmic sperm injectionProportion of cyclesMultivariate logistic regressionMultiple logistic regressionReproductive technologiesNumber of embryosCycle cancellationOvarian reserveAnti-Müllerian hormone as a qualitative marker - or just quantity?
Kotlyar A, Seifer DB. Anti-Müllerian hormone as a qualitative marker - or just quantity? Current Opinion In Obstetrics & Gynecology 2020, 32: 219-226. PMID: 32205525, DOI: 10.1097/gco.0000000000000623.Peer-Reviewed Original ResearchConceptsAnti-Müllerian hormoneOvarian reserve testingClinical pregnancy rateLive birth rateOnset of menopausePremature ovarian insufficiencyNumber of oocytesSignificant predictive valueAMH levelsFertilization cyclesPregnancy rateOvarian insufficiencyIntracycle variabilityOocyte qualityPredictive valueEarly folliclesFetal trisomiesHormoneReproductive technologiesRiskQualitative markersSmall interMenopauseInsufficiencyFollicles
2019
Chapter 25 The Role of Antimullerian Hormone in Assisted Reproduction
Tal R, Seifer D. Chapter 25 The Role of Antimullerian Hormone in Assisted Reproduction. 2019, 403-414. DOI: 10.1016/b978-0-12-813209-8.00025-x.ChaptersAntimullerian hormoneOvarian responseControlled ovarian stimulationOnset of menopausePrimordial follicle poolInformative biochemical markersOvarian stimulationOvarian reserveFertility preservationAbnormal folliculogenesisFollicle poolClinical utilityParacrine regulatorSensitive markerStimulation protocolChronologic ageOvarian folliclesGranulosa cellsBiochemical markersReproductive agingReproductive medicineInverse correlationAssisted reproductionReproductive technologiesClinical application
2018
National survey of the Society for Assisted Reproductive Technology membership regarding insurance coverage for assisted reproductive technologies
Seifer DB, Wantman E, Sparks AE, Luke B, Doody KJ, Toner JP, van Voorhis BJ, Lin PC, Reindollar RH. National survey of the Society for Assisted Reproductive Technology membership regarding insurance coverage for assisted reproductive technologies. Fertility And Sterility 2018, 110: 1081-1088.e1. PMID: 30396552, DOI: 10.1016/j.fertnstert.2018.07.016.Peer-Reviewed Original ResearchConceptsElective single embryo transferHigh annual volumeInsurance coverageInfertility insurance coverageVulnerable populationsMultivariable logistic regressionOverall response rateSingle embryo transferReproductive technologiesSignificant predictive valueFertility preservationCancer patientsOdds ratioTransgender patientsMAIN OUTCOMEPredictive valueResponse rateNumber of casesPatientsPractice settingsLogistic regressionUninsured populationAnnual volumeMajority of respondentsGenetic disorders
2016
Society for Assisted Reproductive Technology and assisted reproductive technology in the United States: a 2016 update
Toner JP, Coddington CC, Doody K, Van Voorhis B, Seifer DB, Ball GD, Luke B, Wantman E. Society for Assisted Reproductive Technology and assisted reproductive technology in the United States: a 2016 update. Fertility And Sterility 2016, 106: 541-546. PMID: 27301796, DOI: 10.1016/j.fertnstert.2016.05.026.Peer-Reviewed Original Research
2014
Antimüllerian hormone as predictor of implantation and clinical pregnancy after assisted conception: a systematic review and meta-analysis
Tal R, Tal O, Seifer BJ, Seifer DB. Antimüllerian hormone as predictor of implantation and clinical pregnancy after assisted conception: a systematic review and meta-analysis. Fertility And Sterility 2014, 103: 119-130.e3. PMID: 25450298, DOI: 10.1016/j.fertnstert.2014.09.041.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Mullerian HormoneBiomarkersEmbryo ImplantationFemaleFertilization in VitroHumansInfertility, FemaleMiddle AgedObservational Studies as TopicOvarian ReserveOvaryOvulation InductionPregnancyPregnancy OutcomePregnancy RatePrevalenceReproducibility of ResultsRisk FactorsSensitivity and SpecificityYoung AdultConceptsPredictor of implantationClinical pregnancy rateAntimüllerian hormoneClinical pregnancyOvarian reservePregnancy rateOdds ratioIVF/intracytoplasmic sperm injectionSystematic reviewSerum AMH levelsPolycystic ovary syndromeReproductive technologiesIntracytoplasmic sperm injectionNondonor cyclesAMH levelsOvary syndromeImplantation rateDiagnostic odds ratioObservational studyMAIN OUTCOMEClinical utilitySperm injectionPregnancyAssisted conceptionFertility treatment
2013
Disparities Between Black and White Women in Assisted Reproductive Technology
Tal R, Seifer D. Disparities Between Black and White Women in Assisted Reproductive Technology. 2013, 73-83. DOI: 10.1007/978-1-4614-7548-4_5.ChaptersBlack race/ethnicityLower clinical pregnancyReproductive technologiesUS health care systemHealth care systemAssisted Reproductive TechnologyRace/ethnicityClinical pregnancyPoor outcomeLive birthrateSevere diseaseART outcomesWhite womenCare systemSocioeconomic statusGenetic factorsSuch disparitiesOutcomesPregnancyConfoundersDisparitiesDisease
2009
Racial and ethnic differences in reproductive potential across the life cycle
Butts SF, Seifer DB. Racial and ethnic differences in reproductive potential across the life cycle. Fertility And Sterility 2009, 93: 681-690. PMID: 19939362, DOI: 10.1016/j.fertnstert.2009.10.047.Peer-Reviewed Original ResearchConceptsRacial disparitiesLive birth rateReproductive health outcomesEthnic groupsRace/ethnicityMenopausal symptomsClinical endpointsMenopausal transitionMEDLINE searchHispanic womenPotential confoundingHealth outcomesReproductive healthReproductive life cycleNumber of reportsPubertal onsetEarly pubertySmall sample sizeEthnic differencesIndependent effectsReproductive technologiesOutcomesBirth rateContinuum of eventsReproductive life spanTrends of racial disparities in assisted reproductive technology outcomes in black women compared with white women: Society for Assisted Reproductive Technology 1999 and 2000 vs. 2004–2006
Seifer DB, Zackula R, Grainger DA, Report S. Trends of racial disparities in assisted reproductive technology outcomes in black women compared with white women: Society for Assisted Reproductive Technology 1999 and 2000 vs. 2004–2006. Fertility And Sterility 2009, 93: 626-635. PMID: 19368916, DOI: 10.1016/j.fertnstert.2009.02.084.Peer-Reviewed Original ResearchConceptsWhite womenCycles of IVFPoor prognostic factorReproductive technology outcomesNon-Hispanic womenBlack womenTubal factorIVF cyclesOvulation disordersCohort studyOvarian reserveIVF outcomesPrognostic factorsUterine factorsReporting of raceMale factorLive birthsMAIN OUTCOMEART outcomesMember clinicsOlder ageRacial disparitiesWomenFresh embryosReproductive technologies
2004
Racial disparity in clinical outcomes from women using advanced reproductive technologies (ART): Analysis of 80,196 ART cycles from the SART database 1999 and 2000
Grainger D, Seifer D, Frazier L, Rall M, Tjaden B, Merrill J. Racial disparity in clinical outcomes from women using advanced reproductive technologies (ART): Analysis of 80,196 ART cycles from the SART database 1999 and 2000. Fertility And Sterility 2004, 82: s37-s38. DOI: 10.1016/j.fertnstert.2004.07.098.Peer-Reviewed Original ResearchAdvanced reproductive technologiesClinical outcomesART cyclesRacial disparitiesReproductive technologiesImpact of retained embryos on the outcome of assisted reproductive technologies
Lee HC, Seifer DB, Shelden RM. Impact of retained embryos on the outcome of assisted reproductive technologies. Fertility And Sterility 2004, 82: 334-337. PMID: 15302280, DOI: 10.1016/j.fertnstert.2004.01.035.Peer-Reviewed Original ResearchConceptsEmbryo transfer cyclesPregnancy outcomesEmbryo transferTransfer cyclesTransfer catheterInitial embryo transferEmbryo transfer catheterAssisted reproductive technology practiceRetained embryosOocyte retrievalImplantation rateDelivery ratePregnancy rateRetrospective analysisMAIN OUTCOMEReproductive technology practiceEmbryo cyclesUse of ultrasoundCatheterAdverse effectsFertilization programFrozen embryosReproductive technologiesOutcomesEmbryo retention
2002
Early follicular serum müllerian-inhibiting substance levels are associated with ovarian response during assisted reproductive technology cycles
Seifer DB, MacLaughlin DT, Christian BP, Feng B, Shelden RM. Early follicular serum müllerian-inhibiting substance levels are associated with ovarian response during assisted reproductive technology cycles. Fertility And Sterility 2002, 77: 468-471. PMID: 11872196, DOI: 10.1016/s0015-0282(01)03201-0.Peer-Reviewed Original ResearchConceptsOvarian responseMIS concentrationsReproductive technology cyclesGreater serum concentrationsGroup of womenOvulation inductionSerum concentrationsMaximum serumRetrospective analysisMAIN OUTCOMESubstance levelsSerum MISSerum samplesMI levelsWomenMature oocytesTechnology cyclesReproductive technologiesOocytesSerumART programsGroupIVFGreater numberDetection and Therapeutic Approaches to Age-Related Infertility
Sharara F, Scott R, Seifer D. Detection and Therapeutic Approaches to Age-Related Infertility. 2002, 24-38. DOI: 10.1007/978-3-642-87690-5_3.Peer-Reviewed Original Research
1999
Infertility treatment and informed consent: current practices of reproductive endocrinologists.
Houmard BS, Seifer DB. Infertility treatment and informed consent: current practices of reproductive endocrinologists. Obstetrics And Gynecology 1999, 93: 252-7. PMID: 9932565, DOI: 10.1016/s0029-7844(98)00389-5.Peer-Reviewed Original ResearchConceptsOvulation inductionCurrent practice patternsInfertility treatmentOvarian cancerReproductive endocrinologistsInformed consentIntrauterine inseminationPractice patternsMost physiciansBoard-certified reproductive endocrinologistsReproductive technologiesPatients of risksOvarian cancer riskLength of treatmentLogistic regression analysisMajority of physiciansAssisted Reproductive TechnologyInvasive therapyCancer riskVerbal consentPossible associationEndocrinologistsCancerPhysiciansCommon changesInfertility Treatment and Informed Consent
HOUMARD B, SEIFER D. Infertility Treatment and Informed Consent. Obstetrics And Gynecology 1999, 93: 252-257. DOI: 10.1097/00006250-199902000-00018.Peer-Reviewed Original ResearchOvulation inductionCurrent practice patternsInfertility treatmentOvarian cancerReproductive endocrinologistsInformed consentIntrauterine inseminationPractice patternsMost physiciansBoard-certified reproductive endocrinologistsReproductive technologiesPatients of risksOvarian cancer riskLength of treatmentLogistic regression analysisMajority of physiciansAssisted Reproductive TechnologyInvasive therapyCancer riskVerbal consentPossible associationCancerEndocrinologistsPhysiciansCommon changes
1998
The detection of diminished ovarian reserve in infertile women
Sharara F, Scott R, Seifer D. The detection of diminished ovarian reserve in infertile women. American Journal Of Obstetrics And Gynecology 1998, 179: 804-812. PMID: 9757994, DOI: 10.1016/s0002-9378(98)70087-0.Peer-Reviewed Original ResearchConceptsOvarian reserveOwn gametesDiminished ovarian reserveFetal cardiac activityLower chanceReproductive technologiesInfertility populationInfertile womenProvocative testsPregnancy lossPregnancy rateInvasive therapyHigh incidenceExpensive treatmentWomenCardiac activityLate 30sEarly 40sMultiple testingDaily challengesPregnancyUltrasonographyInfertilityTherapyClinicians