A Role for Uric Acid and the Nalp3 Inflammasome in Antiphospholipid Antibody-Induced IL-1β Production by Human First Trimester Trophoblast
Mulla MJ, Salmon JE, Chamley LW, Brosens JJ, Boeras CM, Kavathas PB, Abrahams VM. A Role for Uric Acid and the Nalp3 Inflammasome in Antiphospholipid Antibody-Induced IL-1β Production by Human First Trimester Trophoblast. PLOS ONE 2013, 8: e65237. PMID: 23762324, PMCID: PMC3675211, DOI: 10.1371/journal.pone.0065237.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntiphospholipidAntiphospholipid SyndromeBeta 2-Glycoprotein ICARD Signaling Adaptor ProteinsCarrier ProteinsCaspase 1Cell LineCytoskeletal ProteinsFemaleGene Expression RegulationHumansInflammasomesInterleukin-1betaMiceNLR Family, Pyrin Domain-Containing 3 ProteinPregnancyPregnancy Trimester, FirstProtein PrecursorsSignal TransductionToll-Like Receptor 4TrophoblastsUric AcidConceptsIL-1β productionIntrauterine growth restrictionIL-1β secretionAntiphospholipid syndromeIL-1β processingAntiphospholipid antibodiesIL-1βHuman first trimester trophoblast cell lineFirst trimester trophoblast cell lineUric acidNalp3/ASC inflammasomeHuman first trimester trophoblast cellsToll-like receptor 4Human first-trimester trophoblastsFirst trimester trophoblast cellsAnti-β2GPI AbsAdverse pregnancy outcomesAnti-β2GPI antibodiesRecurrent pregnancy lossTLR4-dependent mannerApoptosis-associated speck-like proteinMaternal-fetal interfaceFirst trimester trophoblastsSpeck-like proteinTrophoblast cell lineHeat‐shock–mediated conditional regulation of hedgehog/gli signaling in zebrafish
Shen M, Ozacar A, Osgood M, Boeras C, Pink J, Thomas J, Kohtz J, Karlstrom R. Heat‐shock–mediated conditional regulation of hedgehog/gli signaling in zebrafish. Developmental Dynamics 2013, 242: 539-549. PMID: 23441066, DOI: 10.1002/dvdy.23955.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedEmbryo, NonmammalianGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsHeat-Shock ResponseHedgehog ProteinsHSP70 Heat-Shock ProteinsOncogene ProteinsPromoter Regions, GeneticSignal TransductionTrans-ActivatorsZebrafishZebrafish ProteinsZinc Finger Protein GLI1ConceptsTransgenic linesConditional regulationHeat shockEmbryonic central nervous systemZebrafish transgenic linesNew reporter linesHeat shock activationInducible transgenic linesHedgehog/GLIStem cell proliferationSingle heat shockHh responseHh functionFunction phenotypesPostembryonic rolesReporter linesPromoter elementsHedgehog signalingJuvenile stageSitu hybridizationCell proliferationEarly embryonic lossQuantitative polymerase chain reactionLife cycleNew experimental tools