Metformin therapy increases insulin-like growth factor binding protein-1 in hyperinsulinemic women with polycystic ovary syndrome
Pawelczyk L, Spaczynski RZ, Banaszewska B, Duleba AJ. Metformin therapy increases insulin-like growth factor binding protein-1 in hyperinsulinemic women with polycystic ovary syndrome. European Journal Of Obstetrics & Gynecology And Reproductive Biology 2004, 113: 209-213. PMID: 15063962, DOI: 10.1016/j.ejogrb.2003.09.031.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeQuantitative insulin sensitivity check indexInsulin-like growth factorMetformin therapyBody mass indexIGFBP-1Ovary syndromeHyperinsulinemic womenSerum levelsFree insulin-like growth factorTotal IGF-I levelsGlucose/insulin ratioInsulin sensitivity check indexGrowth factorHyperandrogenic PCOS womenIGFBP-1 concentrationsIGFBP-1 levelsFree testosterone indexIGF-I levelsEnd of therapyProtein 1PCOS womenTestosterone indexCompensatory hyperinsulinemiaMass index