Mevastatin inhibits ovarian theca–interstitial cell proliferation and steroidogenesis
Izquierdo D, Foyouzi N, Kwintkiewicz J, Duleba AJ. Mevastatin inhibits ovarian theca–interstitial cell proliferation and steroidogenesis. Fertility And Sterility 2004, 82: 1193-1197. PMID: 15474095, DOI: 10.1016/j.fertnstert.2004.03.037.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DivisionCells, CulturedFemaleHormone AntagonistsHormonesHydroxymethylglutaryl-CoA Reductase InhibitorsLovastatinProgesteroneRatsRats, Sprague-DawleyTestosteroneTheca CellsConceptsPolycystic ovary syndromeTheca-interstitial cellsCardiovascular riskCultured theca-interstitial cellsVascular smooth muscle proliferationSmooth muscle proliferationPotential therapeutic agentConcentration-dependent inhibitionDiphenyl tetrazolium bromide (MTT) assayConcentration-dependent decreaseDNA synthesisMesenchymal hyperplasiaOvary syndromeTetrazolium bromide assayMuscle proliferationMAIN OUTCOMECulture protein contentSpecific radioimmunoassayEffects of mevastatinT productionTherapeutic agentsMTT proliferationBromide assayDimethylthiazol-2Cell proliferation