Lipopolysaccharide-induced chronic inflammation increases female serum gonadotropins and shifts the pituitary transcriptomic landscape
Garcia C, Velez L, Ujagar N, Del Mundo Z, Nguyen T, Fox C, Mark A, Fisch K, Lawson M, Duleba A, Seldin M, Nicholas D. Lipopolysaccharide-induced chronic inflammation increases female serum gonadotropins and shifts the pituitary transcriptomic landscape. Frontiers In Endocrinology 2024, 14: 1279878. PMID: 38260148, PMCID: PMC10801245, DOI: 10.3389/fendo.2023.1279878.Peer-Reviewed Original ResearchChronic inflammationSerum gonadotropinChronic inflammatory stateFollicle stimulating hormoneAcute inflammatory stressFemale reproductive functionAcute LPSChronic LPSSerum luteinizingFSH secretionPituitary functionInflammatory stateWeekly injectionsGonadotropin productionHormone secretionInflammatory stressFemale miceLPS treatmentSex hormonesStimulating hormoneHormonal secretionChronic effectsParacrine activationReproductive functionInflammation