Effects of oxidants and antioxidants on proliferation of endometrial stromal cells
Foyouzi N, Berkkanoglu M, Arici A, Kwintkiewicz J, Izquierdo D, Duleba AJ. Effects of oxidants and antioxidants on proliferation of endometrial stromal cells. Fertility And Sterility 2004, 82: 1019-1022. PMID: 15474067, DOI: 10.1016/j.fertnstert.2004.02.133.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsVitamin E succinateStromal cellsOxidative stressHypoxanthine/xanthine oxidaseN-acetylcysteineModest oxidative stressXanthine oxidaseDose-dependent inhibitionDiphenyl tetrazolium bromide (MTT) assayDepletion of antioxidantsEndometrial stromaTetrazolium bromide assayReproductive ageMAIN OUTCOMEPathologic conditionsThymidine incorporationIncorporation assayMTT proliferationReactive oxygen speciesBromide assayDimethylthiazol-2EndometriosisComparable findingsProliferationProliferation of ovarian theca‐interstitial cells is modulated by antioxidants and oxidative stress
Duleba AJ, Foyouzi N, Karaca M, Pehlivan T, Kwintkiewicz J, Behrman HR. Proliferation of ovarian theca‐interstitial cells is modulated by antioxidants and oxidative stress. Human Reproduction 2004, 19: 1519-1524. PMID: 15178657, DOI: 10.1093/humrep/deh299.Peer-Reviewed Original ResearchConceptsOxidative stressOvarian theca-interstitial cellsModest oxidative stressPathological conditionsPolycystic ovary syndromeI cellsTheca-interstitial cellsDose-dependent decreaseThecal-interstitial cellsXanthine oxidaseExcessive oxidative stressVitamin E succinateDepletion of antioxidantsMesenchymal hyperplasiaOvarian homeostasisOvary syndromeRat TGreater oxidative stressBiphasic effectIU/Inhibited proliferationSerum-free mediumThymidine incorporationReactive oxygen speciesOvarian mesenchyme