Mevastatin inhibits ovarian theca–interstitial cell proliferation and steroidogenesis
Izquierdo D, Foyouzi N, Kwintkiewicz J, Duleba AJ. Mevastatin inhibits ovarian theca–interstitial cell proliferation and steroidogenesis. Fertility And Sterility 2004, 82: 1193-1197. PMID: 15474095, DOI: 10.1016/j.fertnstert.2004.03.037.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeTheca-interstitial cellsCardiovascular riskCultured theca-interstitial cellsVascular smooth muscle proliferationSmooth muscle proliferationPotential therapeutic agentConcentration-dependent inhibitionDiphenyl tetrazolium bromide (MTT) assayConcentration-dependent decreaseDNA synthesisMesenchymal hyperplasiaOvary syndromeTetrazolium bromide assayMuscle proliferationMAIN OUTCOMECulture protein contentSpecific radioimmunoassayEffects of mevastatinT productionTherapeutic agentsMTT proliferationBromide assayDimethylthiazol-2Cell proliferationEffects of oxidants and antioxidants on proliferation of endometrial stromal cells
Foyouzi N, Berkkanoglu M, Arici A, Kwintkiewicz J, Izquierdo D, Duleba AJ. Effects of oxidants and antioxidants on proliferation of endometrial stromal cells. Fertility And Sterility 2004, 82: 1019-1022. PMID: 15474067, DOI: 10.1016/j.fertnstert.2004.02.133.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsVitamin E succinateStromal cellsOxidative stressHypoxanthine/xanthine oxidaseN-acetylcysteineModest oxidative stressXanthine oxidaseDose-dependent inhibitionDiphenyl tetrazolium bromide (MTT) assayDepletion of antioxidantsEndometrial stromaTetrazolium bromide assayReproductive ageMAIN OUTCOMEPathologic conditionsThymidine incorporationIncorporation assayMTT proliferationReactive oxygen speciesBromide assayDimethylthiazol-2EndometriosisComparable findingsProliferation