2020
Emerging roles for noncoding RNAs in female sex steroids and reproductive disease
Zhang R, Wesevich V, Chen Z, Zhang D, Kallen AN. Emerging roles for noncoding RNAs in female sex steroids and reproductive disease. Molecular And Cellular Endocrinology 2020, 518: 110875. PMID: 32668269, PMCID: PMC7609472, DOI: 10.1016/j.mce.2020.110875.Peer-Reviewed Original ResearchConceptsRole of ncRNAsSteroid hormone productionFemale gametogenesisNcRNA expressionRegulatory networksDNA blueprintNoncoding RNAsFunctional RNAsCentral dogmaNcRNAsBiological processesMolecular biologyRNAMessenger RNAParticular disease stateHormone productionSex steroid hormone productionCritical roleProteinTherapeutic targetReproductive pathologiesPotential diagnostic markerPolycystic ovary syndromeReproductive diseasesFemale sex steroidsControl of Murine Primordial Follicle Growth Activation by IκB/NFκB Signaling
Wright CJ, Cari EL, Sandoval J, Bales E, Sam PK, Zarate MA, Polotsky AJ, Kallen AN, Johnson J. Control of Murine Primordial Follicle Growth Activation by IκB/NFκB Signaling. Reproductive Sciences 2020, 27: 2063-2074. PMID: 32542534, PMCID: PMC7529825, DOI: 10.1007/s43032-020-00225-3.Peer-Reviewed Original ResearchConceptsPrimordial follicle growth activationLargest human genome-wide association studyGrowth activationHuman genome-wide association studiesGenome-wide association studiesLigand/receptor interactionsTranscription factor NFκBInhibitory protein IκBαAssociation studiesIκB proteinsWild-type controlsInhibitory proteinProtein IκBαPrimordial stageNFκB signalingMechanistic insightsReceptor interactionProteinMurine ovariesNFκB pathwayKey membersNFκBSubunit p65NFκB activationIκBβ
2019
Translational activation of maternally derived mRNAs in oocytes and early embryos and the role of embryonic poly(A) binding protein (EPAB)
Esencan E, Kallen A, Zhang M, Seli E. Translational activation of maternally derived mRNAs in oocytes and early embryos and the role of embryonic poly(A) binding protein (EPAB). Biology Of Reproduction 2019, 100: 1147-1157. PMID: 30806655, PMCID: PMC8127035, DOI: 10.1093/biolre/ioz034.Peer-Reviewed Original ResearchConceptsTranslational activationBinding proteinSpecific protein complexesTranslation of mRNAsOocyte maturationCis-acting sequencesEarly embryo developmentProtein complexesXenopus modelEarly embryosKey regulatorGene expressionMolecular mechanismsEmbryo developmentTargeted disruptionMechanistic detailsProteinEarly developmentMRNAMice resultsKey mechanismOocytesActivationMaturationTranscription
2016
The Steroidogenic Acute Regulatory Protein (StAR) Is Regulated by the H19/let-7 Axis
Men Y, Fan Y, Shen Y, Lu L, Kallen AN. The Steroidogenic Acute Regulatory Protein (StAR) Is Regulated by the H19/let-7 Axis. Endocrinology 2016, 158: 402-409. PMID: 27813675, PMCID: PMC5413078, DOI: 10.1210/en.2016-1340.Peer-Reviewed Original ResearchConceptsSteroidogenic acute regulatory proteinRegulatory proteinsAcute regulatory proteinPost-transcriptional levelRate-limiting stepMicroRNA let-7H19/letRegulation of reproductionMurine cell linesLet-7Overexpression of H19Long noncoding RNA H19Regulation of steroidogenesisCellular growthSpecific tissuesNovel mechanismMultiple rolesNovel targetRNA H19StAR expressionExpression variesCell linesRegulationH19Protein