2020
Control of Murine Primordial Follicle Growth Activation by IκB/NFκB Signaling
Wright CJ, Cari EL, Sandoval J, Bales E, Sam PK, Zarate MA, Polotsky AJ, Kallen AN, Johnson J. Control of Murine Primordial Follicle Growth Activation by IκB/NFκB Signaling. Reproductive Sciences 2020, 27: 2063-2074. PMID: 32542534, PMCID: PMC7529825, DOI: 10.1007/s43032-020-00225-3.Peer-Reviewed Original ResearchConceptsPrimordial follicle growth activationLargest human genome-wide association studyGrowth activationHuman genome-wide association studiesGenome-wide association studiesLigand/receptor interactionsTranscription factor NFκBInhibitory protein IκBαAssociation studiesIκB proteinsWild-type controlsInhibitory proteinProtein IκBαPrimordial stageNFκB signalingMechanistic insightsReceptor interactionProteinMurine ovariesNFκB pathwayKey membersNFκBSubunit p65NFκB activationIκBβ
2018
Untapped Reserves: Controlling Primordial Follicle Growth Activation
Kallen A, Polotsky AJ, Johnson J. Untapped Reserves: Controlling Primordial Follicle Growth Activation. Trends In Molecular Medicine 2018, 24: 319-331. PMID: 29452791, PMCID: PMC6482944, DOI: 10.1016/j.molmed.2018.01.008.Peer-Reviewed Original ResearchConceptsPrimordial follicle growth activationDormant primordial folliclesRecovery of eggsCare treatmentHuman ovaryCommon causeLive birthsPrimordial folliclesOocyte qualityOvarian folliclesHealthy offspringGrowth activationReproductive technologiesFolliclesBirthHigh-quality eggsActivationEpigenetic strategiesInfertilityWomen