Dendritic cells and B cells maximize mucosal Th1 memory response to herpes simplex virus
Iijima N, Linehan MM, Zamora M, Butkus D, Dunn R, Kehry MR, Laufer TM, Iwasaki A. Dendritic cells and B cells maximize mucosal Th1 memory response to herpes simplex virus. Journal Of Experimental Medicine 2008, 205: 3041-3052. PMID: 19047439, PMCID: PMC2605233, DOI: 10.1084/jem.20082039.Peer-Reviewed Original ResearchConceptsMemory Th1 cellsDendritic cellsTh1 cellsB cellsIFN-gammaHerpes simplex virus 2 infectionAntiviral protectionSimplex virus 2 infectionMemory CD4 T cellsFurther viral replicationTh1 memory responseHSV-2 infectionCD4 T cellsLocal dendritic cellsVirus 2 infectionAntigen-presenting cellsCytotoxic T lymphocytesMHC class IISite of infectionHerpes simplex virusTh1 responseImmunized miceRecall responsesViral antigensMHC classAutophagy and antiviral immunity
Lee HK, Iwasaki A. Autophagy and antiviral immunity. Current Opinion In Immunology 2008, 20: 23-29. PMID: 18262399, PMCID: PMC2271118, DOI: 10.1016/j.coi.2008.01.001.Peer-Reviewed Original ResearchConceptsViral infectionViral replicationAdaptive antiviral immune responsesEndogenous viral antigensCD4 T cellsMHC class II loading compartmentsAntiviral immune responseCritical effector mechanismAdaptive immune systemViral antigensEffector mechanismsT cellsImmune responseAntiviral immunityImmune systemLoading compartmentCertain virusesInfectionAutophagyRecent studiesCellsAntigenImmunityCellular homeostasis