Effects of sphingosylphosphorylcholine against oxidative stress and acute lung ınjury ınduced by pulmonary contusion in rats
Aksu B, Ayvaz S, Aksu F, Karaca T, Cemek M, Ayaz A, Demirtaş S. Effects of sphingosylphosphorylcholine against oxidative stress and acute lung ınjury ınduced by pulmonary contusion in rats. Journal Of Pediatric Surgery 2014, 50: 591-597. PMID: 25840069, DOI: 10.1016/j.jpedsurg.2014.06.007.Peer-Reviewed Original ResearchConceptsAcute lung injuryPulmonary contusionLung injuryInducible nitric oxide synthaseLung tissueSeverity of lung injurySphingosylphosphorylcholine treatmentAdministered 3 daysNitric oxideAttenuated lung damageOxidative stressNitric oxide synthaseEffects of sphingosylphosphorylcholineGlutathione peroxidaseDepletion of superoxide dismutaseSuperoxide dismutaseLung malondialdehydeHistopathological findingsPositive cellsLung damageImmunohistochemical changesInflammatory processNeutrophil activationOxide synthaseApoptotic cellsEffects of methylene blue in acute lung injury induced by blunt chest trauma.
Ayvaz S, Aksu B, Karaca T, Cemek M, Tarladacalisir Y, Ayaz A, Metin M, Basaran U, Ayvaz A, Aksu F, Pul M. Effects of methylene blue in acute lung injury induced by blunt chest trauma. Hippokratia 2014, 18: 50-6. PMID: 25125953, PMCID: PMC4103043.Peer-Reviewed Original ResearchBlunt chest traumaInducible nitric oxide synthaseChest traumaLung injuryControl groupMale Sprague-Dawley ratsDeoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive cellsNO levelsEC groupTerminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive cellsAcute lung injuryInflammatory cell infiltrationSprague-Dawley ratsNitric oxideActivity of inducible nitric oxide synthaseAlveolar wall thicknessEffect of methylene blueNitric oxide synthaseIncreased hemorrhageLC ratsCell infiltrationImmunohistochemical studiesHistopathological analysisGlutathione peroxidaseLC group