Comparative proteomic network signatures in seminal plasma of infertile men as a function of reactive oxygen species
Agarwal A, Ayaz A, Samanta L, Sharma R, Assidi M, Abuzenadah A, Sabanegh E. Comparative proteomic network signatures in seminal plasma of infertile men as a function of reactive oxygen species. Clinical Proteomics 2015, 12: 23. PMID: 26321892, PMCID: PMC4552280, DOI: 10.1186/s12014-015-9094-5.Peer-Reviewed Original ResearchMembrane metallo-endopeptidaseInfertile menSeminal plasmaSperm functionFertile menLTQ-Orbitrap Elite hybrid mass spectrometer systemProtein foldingNatural reservoir of antioxidantsMale infertilityROS levelsComparison to fertile controlsSeminal plasma of infertile menPost-translational modification of proteinsHigh ROS groupImpairment of sperm functionPathology of male infertilitySeminal plasma proteinsDiagnosis of male infertilityFunction of reactive oxygen speciesMotility of spermPost-translational modificationsFertile groupModification of proteinsInfertile patient groupsOxygen species